Occurrence and analysis of endocrine-disrupting compounds in a water supply system
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This paper presents the study of the occurrence of 10 endocrine-disrupting compounds (EDCs) in 60 water samples using a method for simultaneous quantification and confirmation of the presence of these emerging compounds, using ultra-performance liquid chromatography with electrospray ionization and tandem mass spectrometry (UPLC-ESI-MS/MS). All samples were previously extracted by solid-phase extraction (SPE). Several natural and synthetic hormones (17-β-estradiol, ethinylestradiol, estriol, estrone, progesterone, mestranol, and diethylstilbestrol) and some industrial products (4-n-nonylphenol, 4-tert-octylphenol, and bisphenol A) were chosen for this survey. The analytical limits were calculated for each compound and were used in the identification and quantification of these target compounds in EPAL’s water supply system. In this study, several samples were taken from the main intakes of water (surface and groundwater) used for production of water for human consumption and from different sampling points of the drinking water distribution system (piping, nets, and reservoirs). Some target compounds, such as estriol, 4-tert-octylphenol, mestranol, and nonylphenol, were found in trace amounts in several water samples. However, the studied endocrine-disrupting appeared in very low concentrations when compared with the assessed analytical limits.
KeywordsWater supply system Endocrine-disrupting compounds Ultra-performance liquid chromatography Solid-phase extraction Environmental health
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- Bennie, D. T., Sullivan, C. A., Lee, H. B., Peart, T. E., & Maguire, R. J. (1997). Occurrence of alkylphenols and alkylphenol mono- and diethoxylates in natural water of Laurentian Great Lakes basin and the upper St. Lawrence River. Science of The Total Environment, 193, 263–275.CrossRefGoogle Scholar
- Carvalho, A.R.M. (2012). Monitoring of endocrine disruptors in water supply and WWTP by SPE-UPLC-ESI-MS/MS. EPAL. Master Degree Thesis in Environmental Engineering. Technical University of Lisbon. http://hdl.handle.net/10400.5/5371.
- Council Directive 98/83/EC of 3 November 1998 on the quality of water intended for human consumption. (1998). Official Journal L 330, pp 32–54 (ES, DA, DE, EL, EN, FR, IT, NL, PT, FI, SV).Google Scholar
- Directive 2013/39/EU of the European Parliament and of the Council of 12 August 2013 amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy (Text with EEA relevance). (2013). Official Journal L 226, pp 1–17 (BG, ES, CS, DA, DE, ET, EL, EN, FR, HR, IT, LV, LT, HU, MT, NL, PL, PT, RO, SK, SL, FI, SV).Google Scholar
- Gorga, M., Insa, S., Petrovic, M., & Barceló, D. (2014). Occurrence and spatial distribution of EDCs and related compounds in waters and sediments of Iberian rivers. Science of The Total Environment, 503–504, 69–86.Google Scholar
- Kasprzyk-Hordern, B., Dinsdale, R. M., & Guwy, A. J. (2008). The occurrence of pharmaceuticals, personal care products, endocrine disruptors and ilicit drugs in surface water in South Wales, UK. Water Research, 42(13), 3498–3518.Google Scholar
- Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., Barber, L. B., Buxton, H. T. (2002). Pharmaceuticals, hormones and other organic wastewater contaminants in U.S. streams 1999-2000: a national reconnaissance. Environmental Science Technology, 36(6), 1020–1211.Google Scholar
- López-Roldán, R., Alda, M. L., Gros, M., Petrovic, M., Martin-Alonso, J., & Barceló, D. (2010). Advanced monitoring of pharmaceuticals and estrogens in the Llobregat River basin (Spain) by liquid chromatography-triple quadrupole-tandem mass spectrometry in combination with ultra performance liquid chromatography-time of flight-mass spectrometry. Chemosphere, 80, 1337–1344.CrossRefGoogle Scholar
- ME 72 (2010). Determinação quantitativa de desreguladores endócrinos - Método de Cromatografia de Ultra Resolução associada à espectrometria de massas. Internal method from EPAL.Google Scholar
- Stanford, B. D., & Weinberg, H. S. (2007). Isotope dilution for quantification of steroid estrogens and nonylphenols by gas chromatographic with tandem mass spectrometry in septic, soil and groundwater matrices. Journal of Chromatography A, 1176, 26–36.Google Scholar