Seasonal variation in the acute effects of ozone on premature mortality among elderly Japanese
We conducted a multicity time-series study using monitoring data to assess seasonal patterns of short-term ozone–mortality association among elderly aged 65 years and over in Japan. Daily exposure to ambient ozone was computed using hourly measurements of photochemical oxidants available at multiple monitoring stations in each city. Effects of ozone on daily all-cause non-accidental, cardiovascular, and respiratory mortality were estimated using distributed lag linear models, controlling for confounding by temporal, day of the week, temperature, and flu epidemics. City-level effect estimates were combined using inverse variance meta-analysis. In spring and autumn, a 10-ppbv increase of daily maximum 8-h average ozone concentration in the previous 3 days was associated with 0.69 % (95 % confidence interval (CI): 0.27–1.10), 1.07 % (0.34–1.82), and 1.77 % (0.78–2.77) increases in daily all-cause, cardiovascular, and respiratory mortality, respectively. Forward displacement of respiratory mortality was large during the cold season despite lower ozone concentration. Results were generally independent of fine particulate matter and nitrogen dioxide. Findings suggest significant mortality effects of short-term ozone exposure among the elderly during the moderate season. Those with underlying respiratory diseases were susceptible, even during winter.
KeywordsOzone Mortality Seasonal Air pollution Elderly
- Asia Center for Air Pollution Research. (2006). Tropospheric ozone: A growing threat. Acid Deposition and Oxidant Research Center.http://www.acap.asia/publication/pdf/ozone1.pdf. Accessed 11 April 2012.
- Bocci, V., Valacchi, G., Corradeschi, F., Aldinucci, C., Silvestri, S., Paccagnini, E., et al. (1998). Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. Journal of Biological Regulators and Homeostatic Agents, 12(3), 67–75.Google Scholar
- Devlin, R. B., McDonnell, W. F., Mann, R., Becker, S., House, D. E., Schreinemachers, D., et al. (1991). Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. American Journal of Respiratory Cell and Molecular Biology, 4(1), 72–81.CrossRefGoogle Scholar
- Gryparis, A., Forsberg, B., Katsouyanni, K., Analitis, A., Touloumi, G., Schwartz, J., et al. (2004). Acute effects of ozone on mortality from the “Air Pollution and Health: A European Approach” project. American Journal of Respiratory and Critical Care Medicine, 170(10), 1080–1087.CrossRefGoogle Scholar
- HEI Public Health and Air Pollution in Asia Program. (2010). Public Health and Air Pollution in Asia (PAPA): Coordinated studies of short-term exposure to air pollution and daily mortality in four cities. HEI Research Report 154. Boston, MA: Health Effects Institute.Google Scholar
- Infectious Disease Surveillance Center. (2012). Annual report for incidence of infectious diseases (in Japanese). National Institute of Infectious Diseases. http://idsc.nih.go.jp/idwr/CDROM/Main.html. Accessed 5 March 2012.
- Katsouyanni, K., Samet, J.M., Anderson, H.R., Le Tertre, A., Medina, S.,Samoli, E., et al. (2009). Air pollution and health: A European and North American approach (APHENA). HEI Research Report 142. Boston, MA: Health Effects Institute.Google Scholar
- Kawamoto, T., Pham, T. T. P., Matsuda, T., Oyama, T., Tanaka, M., Yu, H. S., et al. (2011). Historical review on development of environmental quality standards and guideline values for air pollutants in Japan. International Journal of Hygiene and Environmental Health, 214(4), 296–304.CrossRefGoogle Scholar
- Kohno, Y., Matsumura, H., Ishii, T., & Izuta, T. (2005). Establishing critical levels of air pollutants for protecting East Asian vegetation—A challenge. In K. Omasa, I. Nouchi, & L. J. DeKok (Eds.), Proceedings of the 6th international symposium on plant responses to air pollution and global changes (pp. 243–250). Tokyo: Springer.CrossRefGoogle Scholar
- National Research Council. (2008). Estimating mortality risk reduction and economic benefits from controlling ozone air pollution. Washington, DC: National Academies Press.Google Scholar
- Peng, R. D., Dominici, F., & Louis, T. A. (2006). Model choice in time series studies of air pollution and mortality. Journal of the Royal Statistical Sociaty, Series A, 169, 179–198.Google Scholar
- Samet, J. M., Dominici, F., Zeger, S. L., Schwartz, J., & Dockery, D. W. (2000). The National Morbidity, Mortality, and Air Pollution study. Part I: Methods and methodologic issues. HEI Research Report 94. Boston: Health Effects Institute.Google Scholar
- Statistics Bureau. (2010). Quantities of major durable goods possessed per 1000 households and percentages of households possessing major durable goods by area (in Japanese). Ministry of Internal Affairs and Communications, Japan. http://www.e-stat.go.jp/SG1/estat/GL08020103.do?_toGL08020103_&tclassID=000001027311&cycleCode=0&requestSender=search Assessed 11 April 2012.
- The Federation of Electric Power Companies. (2011). Energy and environment: Japanese electric utility industry in the world 2010–2011. The Federation of Electric Power Companies, Japan. http://www.fepc.or.jp/english/library/energy_environment/__icsFiles/afieldfile/2011/02/22/kankyo_E_2010.pdf. Accessed 12 April 2012.
- Yamaji, K., Ohara, T., Uno, I., Tanimoto, H., Kurokawa, J., & Akimoto, H. (2006). Analysis of the seasonal variation of ozone in the boundary layer in East Asia using the Community Multi-scale Air Quality model: what controls surface ozone levels over Japan? Atmospheric Environment, 40(10), 1856–1868.CrossRefGoogle Scholar