Environmental Monitoring and Assessment

, Volume 174, Issue 1–4, pp 693–701 | Cite as

Monitoring of selected veterinary antibiotics in environmental compartments near a composting facility in Gangwon Province, Korea

  • Yong Sik Ok
  • Sung-Chul Kim
  • Kwon-Rae Kim
  • Sang Soo Lee
  • Deok Hyun Moon
  • Kyoung Jae Lim
  • Jwa-Kyung Sung
  • Seung-Oh Hur
  • Jae E. Yang
Article

Abstract

Many studies have been recently reported that veterinary antibiotics released into the environment have a detrimental effect on humans such as the occurrence of antibiotic-resistant bacteria. However, only limited information is available regarding to the release of antibiotics in environmental compartments in Korea. Objectives of this study were to evaluate the concentrations of antibiotics in water, sediment, and soil adjacent to a composting facility in Korea and to determine the dilution effects of antibiotics when released into the environment. Seven antibiotics of chlortetracycline, oxytetracycline, tetracycline, sulfamethazine, sulfamethoxazole, sulfathiazole, and tylosin were evaluated by high-performance liquid chromatography–tandem mass spectrometry following pretreatment using solid-phase extraction to clean the samples. Results showed that the highest concentration of each antibiotic in both aqueous and solid samples was detected from a site adjacent to the composting facility. We also found that the studied water, sediment, and soil samples are contaminated by veterinary antibiotics throughout comparison with studies from other countries. However, relatively lower concentrations of each antibiotic were observed from the rice paddy soil located at the bottom of the water stream. Further research is necessary to continuously monitor the antibiotics release into ecosystems, thereby developing an environmental risk assessment.

Keywords

Veterinary antibiotics Solid-phase extraction Soil Sediment Water 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aga, D. S., Goldfish, R., & Kulshrestha, P. (2003). Application of ELISA in determining the fate of tetracyclines in land-applied livestock wastes. Analyst, 128, 658–662.CrossRefGoogle Scholar
  2. Boxall, A. B. A., Fogg, L., Blackwell, P. A., Kay, P., & Pemberton, E. J. (2002). Review of veterinary medicines in the environment (p. 257). Briston: UK Environment Agency. R&D Technical Report P6-012/8TR.Google Scholar
  3. Bradford, S. A., Segal, E., Zheng, W., Wang, Q., & Hutchins, S. R. (2008). Reuse of concentrated animal feeding operation wastewater on agricultural lands. Journal of Environmental Quality, 37, 97–115.CrossRefGoogle Scholar
  4. Carlson, K., Yang, S., & Kim, S. C. (2004). Antibiotic in the environment: Antibiotics in the Catche La Poudre River. Agronomy News, 24(3), 4–6.Google Scholar
  5. Cars, O., Högberg, L. D., Murray, M., Nordberg, O., Lundborg, C. S., So, A. D., et al. (2008). Meeting the challenge of a concerted global response is needed to tackle rising rates of antibiotic resistance. Without it, we risk returning to the pre-antibiotic era warn. British Medicine Journal, 337, 726–728.Google Scholar
  6. Choi, K. J., Kim, S. G., Kim, C. W., & Kim, S. H. (2007). Determination of antibiotic compounds in water by on-line SPE-LC/MSD. Chemosphere, 66, 977–984.CrossRefGoogle Scholar
  7. Choi, K., Kim, Y., Park, J., Park, C. K., Kim, M. Y., Kim, H. S., et al. (2008). Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea. Science of the Total Environment, 405, 120–128.CrossRefGoogle Scholar
  8. Golet, E. M., Alder, A. C., & Giger, W. (2002). Environmental exposure and risk assessment of fluoroquinolone antibacterial agents in wastewater and river water of the Glatt Valley Watershed, Switzerland. Environmental Science & Technology, 36(17), 3645–3651.CrossRefGoogle Scholar
  9. Gross, B., Montgomery-Brown, J., Naumann, A., & Reinhard, M. (2004). Occurrence and fate of pharmaceuticals and alkylphenol ethoxylate metabolites in an effluent-dominated river and wetland. Environmental Toxicology & Chemistry, 23(9), 2074–2083.CrossRefGoogle Scholar
  10. Ha, J. I., Hong, K. S., Song, S. W., Jung, S. C., Min, Y. S., & Shim, H. C. (2003). Survey of antimicrobial agents used in livestock and fishes. Korean Journal of Veterinary Public Health, 27, 205–217.Google Scholar
  11. Halling-Sorensen, B., Sengelov, G., & Tjornelund, J. (2002). Toxicity of tetracyclines and tetracycline degradation products to environmentally relevant bacteria including selected tetracycline-resistant bacteria. Archives of Environmental Contamination & Toxicology, 42, 263–271.CrossRefGoogle Scholar
  12. Hamscher, G., Sczesny, S., Höper, H., & Nau, H. (2002). Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Analytical Chemistry, 74, 1509–1518.CrossRefGoogle Scholar
  13. Heim, S., Schwarzbauer, J., & Littke, R. (2004). Monitoring of waste deposit derived groundwater contamination with organic tracers. Environmental Chemistry Letters, 2, 21–25.CrossRefGoogle Scholar
  14. Johansson, N., & Mollby, R. (2006). Antibiotics in the environment. In B. E. Bengtsson, B. Bunnarsson, T. Wall, A. Wennmalm (Eds.), Environment and pharmaceuticals, poteket, A. B. (pp. 73–83). Stockholm: Stockholm County Council, Stockholm University.Google Scholar
  15. Kemper, N. (2008). Veterinary antibiotics in the aquatic and terrestrial environment. Ecological Indicators, 8, 1–13.CrossRefGoogle Scholar
  16. Kim, K.-R., Owens, G., Kwon, S.-I., So, K.-H., Lee, D.-B., & Ok, Y. S. (2010). Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment. Water, Air, and Soil Pollution. doi:10.1007/s11270-010-0412-2.
  17. Kim, S. C., & Carlson, K. (2007a). Quantification of human and veterinary antibiotics in water and sediment using SPE/LC/MS/MS. Analytical and Bioanalytical Chemistry, 387, 1301–1315.CrossRefGoogle Scholar
  18. Kim, S. C., & Carlson, K. (2007b). Temporal and spatial trends in the occurrence of human and veterinary antibiotics in aqueous and river sediment matrices. Environmental Science and Technology, 41(1), 50–57.CrossRefGoogle Scholar
  19. Kim, Y., Choi, K., Jung, J., Park, S., Kim, P.-G., & Park, J. (2007). Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environment International, 33, 370–375.CrossRefGoogle Scholar
  20. Kim, Y., Jung, J., Kim, M., Park, J., Boxall, A. B. A., & Choi, K. (2008). Prioritizing veterinary pharmaceuticals for aquatic environment in Korea. Environmental Toxicology and Pharmacology, 26, 167–176.CrossRefGoogle Scholar
  21. Klavarioti, M., Mantzavinos, D., & Kassinos, D. (2008). Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes. Environment International, 26, 167–176.Google Scholar
  22. Kolpin, D., Furlong, E., Meyer, M., Thurman, E., Zaugg, S., Barber, L., et al. (2002). Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999–2000: A national reconnaissance. Environmental Science & Technology, 36, 1202–1211.CrossRefGoogle Scholar
  23. Kong, W. D., Zhu, Y. G., Liang, Y. C., Zhang, J., Smith, F. A., & Yang, M. (2007). Uptake of oxytetracycline and its phytotoxicity to alfalfa (Medicago sativa L.). Environmental Pollution, 147, 187–193.CrossRefGoogle Scholar
  24. Kümmerer, K. (2008). Pharmaceuticals in the environment: Source, fate, effects and risks (3rd ed., pp. 75, 83, 85). New York: Springer-Verlag.Google Scholar
  25. Lin, A. Y. C., Plumlee, M. H., & Reinhard, M. (2006). Natural attenuation of pharmaceuticals and alkylphenol polyethoxylate metabolites during river transport: Photochemical and biological transformation. Environmental Toxicology and Chemistry, 25, 1458–1464.CrossRefGoogle Scholar
  26. Lin, A. Y. C., Yu, T. H., & Lin, C. F. (2008). Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan. Chemosphere, 74, 131–141.CrossRefGoogle Scholar
  27. Montforts, M. H. M. M., Kalf, D. F., Vlaardingen, P. L. A. V., & Linders, J. B. H. J. (1999). The exposure assessment for veterinary medicinal products. The Science of the Total Environment, 225(1/2), 119–133.CrossRefGoogle Scholar
  28. NVRQS (2005). Veterinary antibiotics residue over the critical level in livestock products. Anyang: National Veterinary Research and Quarantine Services.Google Scholar
  29. Ok, Y. S., Chang, S. X., & Feng, Y. (2007). Sensitivity to acidification of forest soils in two contrasting watersheds in the oil sands region of Alberta. Pedosphere, 17(6), 747–757.CrossRefGoogle Scholar
  30. Park, J., Kim, M. H., Choi, K., Kim, Y. H., & Kim, M. Y. (2007). Environmental risk assessment of pharmaceuticals: Model application for estimating pharmaceutical exposures in the Han River basin (pp. 2, 10). Korea: Korea Environment Institute.Google Scholar
  31. SAS (2004). SAS/Insight 9.1 user’s guide (Vol. 1). North Carolina: SAS Institute Inc.Google Scholar
  32. Seo, Y. H., Choi, J. K., Kim, S. K., Min, H. K., & Jung, Y. S. (2007). Prioritizing environmental risks of veterinary antibiotics based on the use and the potential to reach environment. Korean Journal of Soil Science and Fertilizer, 40(1), 43–50.Google Scholar
  33. Tolls, J. (2001). Sorption of veterinary pharmaceuticals in soil: A review. Environmental science & Technology, 35, 3397–3406.CrossRefGoogle Scholar
  34. Turku, I., Sainio, T., & Paatero, E. (2007). Thermodynamics of tetracycline adsorption on silica. Environmental Chemistry Letters, 5, 225–228.CrossRefGoogle Scholar
  35. Vaclavik, E., Halling-Sorensen, B., & Ingerslev, F. (2004). Evaluation of manometric respiration tests to assess the effects of veterinary antibiotics in soil. Chemosphere, 56, 667–676.CrossRefGoogle Scholar
  36. VMD (2005). Sales of antimicrobial products authorized for use as veterinary medicines, antiprotozoals, antifungals, growth promoters and coccidiostats, in the UK in 2004. UK: Veterinary Medicines Directorate.Google Scholar
  37. Wise, R. (2002). Antimicrobial resistance: Priorities for action. Journal of Antimicrobial Chemotherapy, 49, 585–586.CrossRefGoogle Scholar
  38. Winckler, C., & Grafe, A. (2001). Use of veterinary drugs in intensive animal production-evidence for persistence of tetracycline in pig slurry. Journal of Soils Sediments, 1, 66–70.CrossRefGoogle Scholar
  39. Yang, J. E., Lee, W. Y., Ok, Y. S., & Skousen, J. (2009). Soil nutrient bioavailability and nutrient content of pine trees (Pinus thunbergii) in areas impacted by acid deposition in Korea. Environmental Monitoring and Assessment, 157, 43–50.CrossRefGoogle Scholar
  40. Yoon, Y. M., Ok, Y. S., Kim, D. Y., & Kim, J. G. (2004). Agricultural recycling of the by-product concentrate of livestock wastewater treatment plant processed with VSEP RO and bio-ceramic SBR. Water Science and Technology, 49(5/6), 405–412.Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Yong Sik Ok
    • 1
  • Sung-Chul Kim
    • 1
  • Kwon-Rae Kim
    • 2
  • Sang Soo Lee
    • 1
  • Deok Hyun Moon
    • 3
  • Kyoung Jae Lim
    • 1
  • Jwa-Kyung Sung
    • 2
  • Seung-Oh Hur
    • 2
  • Jae E. Yang
    • 1
  1. 1.College of Agriculture and Life SciencesKangwon National UniversityChuncheonSouth Korea
  2. 2.National Academy of Agricultural ScienceSuwonSouth Korea
  3. 3.Department of Environmental EngineeringChosun UniversityGwangjuSouth Korea

Personalised recommendations