Advertisement

Environmental Monitoring and Assessment

, Volume 124, Issue 1–3, pp 309–320 | Cite as

N-ethyl-3-carbazolecarboxaldehyde-3-thiosemicarbazone: a new extractive spectrophotometric reagent for the determination of copper(II) in environmental and pharmaceutical samples

  • K. Janardhan Reddy
  • J. Rajesh Kumar
  • S. Lakshmi Narayana
  • C. Ramachandraiah
  • T. ThriveniEmail author
  • A. Varada Reddy
Original Article

Abstract

N-ethyl-3-carbazolecarboxaldehyde-3-thio- semicarbazone (ECCT) as an new analytical reagent used for the development of a highly sensitive extractive spectrophotometric method for the determination of copper(II). The ECCT forms a greenish-yellow colored 1:1 (M:L) complex with copper(II) at pH 3.0, which is well extracted into n-butanol and shows maximum absorbance at 380nm. The color of the complex is stable for more than forty eight hours. The system obey Beer's law in the range 0.4–3.6 with 2.243 × 104lmol−1cm−1, 2.83 × 10-3μgcm−2 molar absorptivity and Sandell's sensitivity respectively. The regression coefficient is 0.412 with 0.99 correlation coefficient. The precision and accuracy of the method was checked by finding the relative standard deviation (0.422%). This developed method has been successfully employed for the determination of copper(II) in environmental and pharmaceutical samples. The method is evaluated by analyzing samples from the bureau of analyzed samples (BCS 233, 266, 216/1, 207 and 179) and by inter comparison of experimental values using AAS.

Keywords

Copper(II) N-ethyl-3-carbazolecarboxaldehyde-3-thiosemicarbazone Spectrophotometry Environmental samples Pharmaceutical samples 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cristofol, E., Rojas, F.S., & Pavon, J.M.C. (1991). Evaluation of various N- phenylthiosemicarbazones as chromogenic reagents in spectrophotometric analysis. Talanta, 38, 445–448.CrossRefGoogle Scholar
  2. Desai, M.J., & Desai, K.K. (1999). Spectrophotometric determination of copper(II) and iron(III) with 2,4-dihydroxy-5-bromoacetophenonethiosemicarbazone. Asian Journal of Chemistry, 11(4), 1313–1316.Google Scholar
  3. Eichhorn, G.L. (1975) Inorganic biochemistry. New York: Elsevier Scientific Publishing Company.Google Scholar
  4. Kocharekar, Archana, R., & Thakkar, N.V. (2004). Extractive Spectrophotometric determination of copper(II) and its applications in pharmaceutical samples and alloys. Journal of Scientific and Industrial Research, 63(3), 283–286.Google Scholar
  5. Kudapali, Y.S., & Suresh, T. (2004). Spectrophotometric determination of copper(II) with 2,5-dihydroxyaceto- phenonebenzoic hydrozone. Oriental Journal of Chemistry, 20(2), 313–316.Google Scholar
  6. Lopez-de-Alba, P., Loepz-Martinez, L., & Amordor-Hernandez, J. (1999). Spectrophotometric determination of copper in medical formulations, wheat bran and drinking water. Boletin de la Sociadad chilena de quimica, 44(4), 469–477.Google Scholar
  7. Lokande, R.S., Poman, S.V., & Kapadi, U.R. (2001). Extractive spectrophotometric determination of copper(II) with 4-chloroisonitrosoacetophenone thiosemicarbazone. Asian Journal of Chemistry, 13(3), 1222–1224.Google Scholar
  8. Lokande, R.S., Nirupa, S., & Chaudhary, A.B. (2002). Spectrophotometric determination of copper(II) with 2,H-benzopran-2-one-3-acetyl thiosemicarbazone. Asian Journal of Chemistry, 14(1), 149–152.Google Scholar
  9. Lokande, R.S., & Jaywant, A.S. (1999). Extractive spectrophotometric determination of copper with p-methyl- isonitrasoacetophenone hydrazone. Asian Journal of Chemistry, 11(3), 1040–1042.Google Scholar
  10. Ma, T., Liu, M., Hu, C., Liu, K., & Liu, Z. (1999). Spectrophotometric study on Cu(II) with pyruvaldehyde (N, N'-dibutyl)bis-thiosemicarbazone. Ziran Kexueban, 31, 70–72.Google Scholar
  11. Patel, A.L., & Patel, I.J. (2000). Spectrophotometric determination of copper(II) with benzaldehyde-4-(2′-hydroxy-5′-sulfophenyl)-3-thiosemicarbazone (BHST). Journal of Institute Chemical, 72(1), 8–8.Google Scholar
  12. Reddy, A.V., & Reddy, Y.K. (1986). Sequential Extraction and Determination of Copper and Nickel with 2,4-dihydroxy acetophenone thiosemicarbazone. Talanta, 33(7), 617– 619.CrossRefGoogle Scholar
  13. Reddy, B.K., Kumar, J.R., Reddy, K.J., Sarma, L.S., & Reddy, A.V. (2003). A rapid and sensitive extractive spectrophotometric determination of copper(II) in pharmaceutical and environmental samples using benzyldithiosemicarbazone. Analytical Science, 19, 423–428.CrossRefGoogle Scholar
  14. Reddy, K.H. & Prasad, N.P.L. (2004). Spectrophotometric Determination of copper(II) in edible oils and seeds using novel oximethiosemicarbazones. Indian Journal of Chemistry, 43A(1), 111–114.Google Scholar
  15. Reddy, K.H. & Chandrasekhar, K.B. (2001). Simultaneous first derivative spectrophotometric determination of nickel(II) and copper(II) in alloys with diacetyl monooxime benzoylhydrazone. Indian Journal of Chemistry, 40(7), 27–732.Google Scholar
  16. Sandell, E.B. (1959). Colorimetric determination of trace metals. NY: Inter Science.Google Scholar
  17. Sarma, L.S., Kumar, J.R., Reddy, K.J., & Reddy, A.V. (2005). Development of an extractive spectrophometric method for the determination of copper(II) in leafy vegitable and pharmaceutical samples using pridoxal-4-phenyl-3 - thiosemicarbazone(PPT). Journal of Agricultural and Food Chemistry, 53, 5492–5498.CrossRefGoogle Scholar
  18. Underwood, E.J. (1979). Trace Elements in human and animal nutrition (4th Ed.). New York: Academic Press.Google Scholar
  19. Vogel, A.I. (1961). A text book of quantitative inorganic analysis. London, UK: Longman, Green.Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • K. Janardhan Reddy
    • 1
  • J. Rajesh Kumar
    • 1
  • S. Lakshmi Narayana
    • 1
  • C. Ramachandraiah
    • 1
  • T. Thriveni
    • 1
    Email author
  • A. Varada Reddy
    • 1
  1. 1.Analytical Chemistry Division, Department of ChemistrySri Venkateswara UniversityTirupatiIndia

Personalised recommendations