The Born in Guangzhou Cohort Study (BIGCS)
- 1k Downloads
The Born in Guangzhou Cohort Study (BIGCS) is a large-scale prospective observational study investigating the role of social, biological and environmental influences on pregnancy and child health and development in an urban setting in southern China. Pregnant women who reside in Guangzhou and who attend Guangzhou Women and Children’s Medical Center (GWCMC) for antenatal care in early pregnancy (<20 weeks’ gestation) are eligible for inclusion. Study recruitment commenced in February 2012, with an overall participation rate of 76.3%. Study recruitment will continue until December 2018 to achieve the target sample size of 30,000 mother–child pairs. At 30 April 2016, a total of 75,422 questionnaires have been collected, while 14,696 live births have occurred with planned follow-up of cohort children until age 18 years. During the same period a total of 1,053,000 biological samples have been collected from participants, including maternal, paternal and infant blood, cord blood, placenta, umbilical cord, and maternal and infant stool samples. The dataset has been enhanced by record linkage to routine health and administrative records. We plan future record linkage to school enrolment and national examination records.
KeywordsDesign Cohort study Child Pregnancy Record linkage
We are grateful to the pregnant women who have participated in BIGCS and all obstetric care providers who have assisted us in the implementation of the study. We especially want to thank Professor Charles Larson for useful comments on the project. BIGCS study is supported by the National Natural Science Foundation of China (81673181), the Guangzhou Science Technology and Innovation Commission (201508030037, 2014A020213022), and the Guangdong Provincial Department of Science and Technology (2012J5100038).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Kassebaum NJ, Bertozzi-Villa A, Coggeshall MS, Shackelford KA, Steiner C, Heuton KR, et al. Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9947):980–1004. doi: 10.1016/S0140-6736(14)60696-6.CrossRefPubMedPubMedCentralGoogle Scholar
- 3.National Health and Family Planning Commission of the People’s Republic of China. Statistics of Health and Family Planning in 2015. http://www.nhfpc.gov.cn/ewebeditor/uploadfile/2016/0820160805160410398 pdf. (in Chinese). Accessed 11 Aug 2016.
- 4.Statistics Bureau of Guangzhou Municipality. Principal Aggregate Indicators on National Economic and Social Development and Growth Rates in Annual Statistics of 2015. http://data.gzstats.gov.cn/gzStat1/chaxun/njsj.jsp. Accessed 16 April 2016.
- 11.Wei M, Bian X, Squires J, Yao G, Wang X, Xie H, et al. Studies of the norm and psychometrical properties of the ages and stages questionnaires, third edition, with a Chinese national sample. Chin J Pediatrics. 2015;53(12):913–8.Google Scholar
- 12.Group BMDC. Gesell developmental diagnosis scale. Beijing: Beijing Mental Development Cooperative Group; 1985.Google Scholar
- 13.Nation Bureau of Statistics of China. Annual data. http://data.stats.gov.cn/index.htm. Accessed 15 Feb 2017.
- 15.Metzger BE, Gabbe SG, Persson B, Buchanan TA, Catalano PA, Damm P, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care. 2010;33(3):676–82. doi: 10.2337/dc09-1848.CrossRefPubMedGoogle Scholar
- 16.Shen S, Lu J, Zhang L, He J, Li W, Chen N, et al. Single fasting plasma glucose measurement compared with 75 g oral glucose-tolerance test in prediction of adverse perinatal outcomes: a prospective cohort study from China. Lancet. 2016;388(Suppl 1):S8. doi: 10.1016/S0140-6736(16)31935-3.CrossRefPubMedGoogle Scholar
- 20.He JR, Liu Y, Lu JH, Shen SY, Li WD, Guo Y, et al. Passive smoking during pregnancy undermines maternal mental health: results from the Born in Guangzhou Cohort Study, China. Poster Abstract. The Lancet and Chinese Academy of Medical Sciences (CAMS) Health Summit; Beijing, China; 2015.Google Scholar
- 21.Lu JH, Guo Y, Shen SY, Hu F, Chen NN, Wu YF, et al. Association between inflammatory reaction at late pregnancy and the risk of postpartum depression: a prospective cohort stud. Chin J Woman Child Health Res. 2014;25(3):391–3.Google Scholar