The MRC National Survey of Health and Development reaches age 70: maintaining participation at older ages in a birth cohort study
A life course approach to ageing relies on maintaining participation rates in national birth cohorts and other long-term longitudinal studies. This reduces the risk of selective attrition biasing associations between lifetime risk factors and health outcomes in later life and ensures the studies remain as representative as possible of the original population. We report the participation patterns for a postal questionnaire and home visit at 68–69 years of study members in the MRC National Survey of Health and Development, the oldest and longest-running British birth cohort study. We investigated how participation varied by lifetime and recent contact, health status, previous clinical feedback and study engagement, taking account of prior socioeconomic and cognitive characteristics. Overall participation and home visit participation remained high (94 and 80%, respectively) and there were no gender differences. Participation was higher in those with higher levels of prior contact and lower in those with the poorest health status. Having previously received clinical feedback on actionable blood results was associated with reduced home visit participation but other forms of clinical feedback were not associated with subsequent participation. Activities that fostered study engagement were associated with increased home visit participation. These findings inform strategies to maintain participation in life course studies.
KeywordsParticipation Birth cohort Attrition Older adults Longitudinal study Life course epidemiology
A life course approach to ageing investigates how biological, psychological and social factors from early life onwards, and across generations, affect health and its change with age in later life [1, 2]. There is growing evidence that biological ageing, manifesting as premature mortality, increased risk of chronic diseases, and decline in physical and cognitive capability with subsequent increases in functional limitations and difficulties with activities of daily living have their origins in environmental exposures and experiences earlier in life . They also share certain underlying ageing processes post maturity that occur at the body system, cellular or molecular levels that lead to reduced physiological reserve . There is also growing evidence that psychological and social wellbeing in later life have their origins earlier in life, albeit based on a somewhat different set of past exposures and experiences than those associated with biological ageing [5, 6]. Less well studied, from a life course perspective, are the lifetime determinants of the common health symptoms and conditions which are often the sequelae of biological ageing, such as chronic pain, incontinence and fatigue, which can impair quality of life and lead to a loss of independence.
Birth cohorts, and other life course studies, that follow population samples from early life into old age are valuable because they facilitate the study of lifelong health and its change across all phases of life, including periods of development and loss of capacity . The MRC National Survey of Health and Development (NSHD), the oldest of the British birth cohort studies, whose participants reached age 70 in 2016, is a major resource for testing life course hypotheses on the extent of continuity and change in biological function and wellbeing, the development of disease risk and multi-morbidity, and their lifetime determinants and consequences . The 24th and most recent follow-up, a postal questionnaire at 68 years followed by a home visit at 69 years, focused on morbidity and its consequences; and repeated functional and mental health assessments, updated reports of health and life circumstances, and collected a third blood sample. The postal questionnaire captured common health conditions, including chronic pain, fatigability, poor sleep quality and incontinence. The home visit captured a wide range of reported doctor diagnosed conditions; and collected more detail than before on functional limitations, difficulties with daily household and personal tasks, and use of health and social services (see Table S1, supplementary information).
Maintaining participation rates is important to reduce the risk of selective attrition biasing observed associations with lifetime risk factors [9, 10, 11, 12], and because one of the aims of NSHD is to remain as representative as possible of the general population born in mainland Britain in the post war period . Previous studies of older people suggest that permanent withdrawals and non-participation become increasing problems with advancing age [14, 15, 16]. We do not know if this also applies to lifelong participants in a birth cohort study. In NSHD and other studies, it has been shown that low educational attainment, mild cognitive impairment and socioeconomic disadvantage are key risk factors for drop out [13, 17, 18, 19]. Poor physical health can also increase risk of drop out, [16, 18, 19] although some studies with medical screening find the opposite .
In a birth cohort study with lifelong follow-up such as NSHD, some study members take part in all the sweeps whereas others decide not to participate in one or more sweeps without permanently withdrawing from the study. The level of prior contact is likely to be a good indicator of future participation, perhaps acting as a proxy for sense of belonging to a study, sense of duty, or because of other sociodemographic or behavioural attributes associated with participation. However few studies have looked at attrition over several waves in longitudinal studies;  those that have generally compare predictors of different types of attrition [17, 20].
Retention in longitudinal studies may be affected by the methods used by the study team to invite study members to take part in follow-ups, [21, 22] provide individual and general feedback, and encourage study belonging; and by the perceived quality of past interactions with the team. Since the 23rd follow-up, a clinical assessment at age 60–64,  the NSHD study team has purposefully had more interaction with study members than ever before, through letters reporting clinically relevant results or responding to individual comments or queries, by holding celebratory events for study members on their 65th and 70th birthdays,  and by involving some in media interviews and public events. We anticipated that this increased level of engagement would have beneficial effects on participation rates; although we were also concerned to examine whether increased feedback of clinically relevant findings, because of advancing age and the introduction of more detailed clinical assessments, was associated with reduced future participation, perhaps if those affected found this feedback worrying or disheartening.
In this paper, we report the participation patterns of NSHD study members at the 68–69 year follow-up and how these patterns relate to lifetime and recent contact, recent health status, receiving clinical feedback or being more engaged with the study at the preceding data collection. We test whether any observed associations were confounded by individual characteristics shown to affect participation at earlier ages [13, 24, 25].
The NSHD is a representative sample of 5362 males and females who were born in England, Scotland and Wales in one week in March 1946 [8, 13, 24]. At the 24th follow-up, the target sample was 2816 study members still living in mainland Britain; this is the maximum sample used in the analyses. Of the remaining 2546 (47%) study members: 957 (18%) had already died, 620 (12%) had previously withdrawn permanently, 574 (11%) lived abroad, and 395 (7%) had remained untraceable for more than 5 years.
The postal questionnaire was sent out when study members were age 68; up to two reminder letters were sent to those who did not return a completed questionnaire. The home visit by a research nurse including blood sample collection took place at age 69 for the majority (97%), and at 70 years for the remainder. A short questionnaire, covering questions the research nurse asked at the home visit was posted to study members who did not wish to have a nurse visit. For this data collection, we obtained ethical approval from the NRES Queen Square REC (14/LO/1073) and Scotland A REC (14/SS/1009). This also included a protocol for collecting data on behalf of those who no longer had capacity to give consent (supplementary information).
A measure of lifetime contact was derived by counting the number of data collections to the whole sample that each study member had taken part in, up to 60–64 years (maximum 23). A measure of the level of recent contact at the 60–64 year data collection distinguished: those who had completed a postal questionnaire and a clinic visit; those who completed a postal questionnaire and a home (rather than a clinic) visit; and a further three groups who had completed just one of the possible components (clinic or home visit or postal questionnaire). We also included two groups who had not taken part in the preceding data collection, either because they were unwilling or unable, or because they were only traced or had returned to live in mainland Britain after the 60–64 year data collection had finished.
Recent health status
At age 60–64, we used a count of the number of clinical disorders (0, 1, 2, 3, 4, 5+) as a measure of recent health status . To be included in this variable, study members required complete data on many health variables from the postal questionnaire and the home or clinic visit; therefore we included an item missing category. At age 68, general health was rated on the postal questionnaire using a five point Likert-scale from excellent to poor. Whether there was a longstanding illness and if this limited daily life was also reported. We used reported falls in the last year (categorised as none, 1, 2 or 3+) and four common health symptoms assessed using standardised scales: chronic pain,  fatigability,  incontinence,  and sleep quality [30, 31] (supplementary information). We also included item missing categories for these health measures which included between 10 and 337 participants.
Previous clinical feedback
At 60–64 years, all clinical assessments (bloods, and cardiovascular and bone density imaging) were reviewed by the study doctor or relevant specialists, and participants were sent letters giving clinically relevant results. Participants with results outside normal ranges (but not actionable), were recommended to see the GP at their next appointment, those with actionable levels were advised to see the GP as soon as possible and the study doctor contacted the GP and participant directly if necessary . Lifestyle advice was appended to bone density results as appropriate. We defined three variables indicating the feedback received on blood tests (actionable; outside normal range; all within normal range), cardiovascular imaging (letter indicating high level of plaque, or abnormal findings from echocardiogram), and bone density imaging (letter indicating osteoporosis, osteopenia or within normal range).
We used three indicators to denote study engagement. First, during the data collection at age 60–64, study members in the target sample who gave extra comments or had queries received personal letters from the study director. Second, for those completing a clinic or home visit at age 60–64 we identified those who accepted our invitation to attend one of the four parties held to celebrate the NSHD’s 65th birthday or to provide memories of being in the study. A third variable denoted those in the latest target sample who responded positively when asked during the follow-up at age 68–69 if they would like to take part in public events or be interviewed by the media.
Covariates: prior socioeconomic and cognitive characteristics
We chose socioeconomic and cognitive characteristics that were strongly associated with participation in this study at earlier sweeps . These were: being in manual or non-manual occupations [taken at age 53 or earlier if missing (n = 34)]; educational qualifications (advanced level or equivalent, up to ordinary level or equivalent, none) by age 26; and a standardised measure of childhood cognitive ability measured at age 8, using tests of reading comprehension, pronunciation, vocabulary, and non-verbal reasoning . Where data on childhood cognitive tests were missing at age 8 (n = 112), standardised scores from assessments at age 11 or 15 were used.
How the overall participation rates at age 68–69 and the home visit participation rate at age 69 varied by prior contact, recent health status, clinical feedback, study engagement, and socioeconomic and cognitive characteristics was first assessed using Chi squared tests. Logistic regression models were then used to examine the associations of overall and home visit participation at 68–69 years with lifetime and recent contact, adjusting for sex and socioeconomic and cognitive characteristics. The logistic regression models were repeated for each indicator of health status, clinical feedback and study engagement that showed univariable associations with overall or home visit participation, adjusting for lifetime contact, sex and socioeconomic and cognitive characteristics. The clinical feedback and study engagement indicators were additionally adjusted for recent health status.
Participation at 68–69 years
The postal questionnaire was completed by 2367 study members living in England, Scotland and Wales, representing 84% of the target sample for the postal questionnaire (Fig. 1). The home visit was completed by 2148 study members, representing 80% of the target sample for the home visit, and a further 2% (55) answered the interview questions on an additional postal questionnaire when a home visit was not possible. Of those invited to have home visit, 11 were unable to give informed consent and the incapacity protocol was initiated.
Overall, we obtained data from 2638 (94%) study members: 1978 completed a postal questionnaire and a home visit; 170 completed a home visit only; and 490 completed a postal questionnaires only. Of the 2148 who had a home visit, 96% were willing to have a blood sample taken, which was successfully obtained for 91%.
Overall and home visit participation at 68–69 years in the MRC National Survey of Health and Development by sex, prior participation and recent health status
Variable (maximum sample for overall/home visit participation)
Home visit participation
No. participants/maximum sample
No. participants/maximum sample
Sex (n = 2816/2698)
No of lifetime contacts (n = 2816/2698)
Contact at age 60–64 (n = 2816/2698)
PQ + CV
PQ + HV
Unwilling or unable (‘Temporary refusal’)
Traced or returned to GB after 64 years
Recent health status
Number of clinical disorders at age 60–64 (n = 1979/1938)a
Self-rated health at age 68 (n = 2318)
Limiting longstanding illness at age 68 (n = 2318)
Limiting longstanding illness
Longstanding illness, not limiting
No longstanding illness
Chronic pain at age 68 (n = 2318)c
Chronic widespread pain
Chronic regional pain
Poor physical fatigability score at age 68 (n = 2318)d
Poor sleep quality at age 68 (n = 2318)e
Incontinence at age 68 (n = 2318)f
Fallen in last year at age 68 (n = 2318)
3 + falls
Is participation at 68–69 years affected by prior contact?
Of those in the target sample at 68–69 years, a third (32%) had participated in all 23 previous data collections, over half (55%) in at least 22, and over two-thirds (69%) in at least 21 data collections.
Those with higher levels of lifetime contact or contact at the data collection at age 60–64 had higher overall and home visit participation rates at age 68–69 (Table 1). Those who had completed a postal questionnaire and a clinic visit at this preceding data collection had the highest overall participation and home visit participation rates at 68–69 years (98 and 93%); those choosing a home (rather than a clinic) visit, or not completing both the postal questionnaire and a visit, had lower subsequent participation. Those who were contacted but did not take part at the preceding data collection had the lowest subsequent participation rates (52 and 34%); and those who were traced or returned to live in Great Britain between these two data collections had participation rates of 75 and 61% respectively.
Odds ratios (95% confidence intervals) of overall participation and home visit participation at 68–69 years by lifetime and recent contact
Odds ratio (95% confidence intervals)
Overall participation (n = 2499)
Home visit participation (n = 2404)
Number of lifetime contacts (per category)
1.2 (1.0, 1.4)
1.2 (1.0, 1.4)
1.1 (1.0, 1.3)
1.1 (1.0, 1.3)
Contact at age 60–64
PQ + CV
PQ + HV
0.61 (0.32, 1.2)
0.83 (0.43, 1.6)
0.30 (0.21, 0.41)
0.37 (0.26, 0.52)
0.20 (0.10, 0.40)
0.22 (0.11, 0.44)
0.38 (0.22, 0.66)
0.41 (0.24, 0.72)
0.11 (0.05, 0.28)
0.16 (0.06, 0.40)
0.09 (0.05, 0.18)
0.12 (0.06, 0.23)
0.13 (0.08, 0.21)
0.16 (0.10, 0.27)
0.05 (0.04, 0.07)
0.06 (0.04, 0.08)
0.03 (0.01, 0.05)
0.03 (0.02, 0.05)
0.04 (0.03, 0.06)
0.05 (0.03, 0.07)
Newly traced or returned to GB
0.09 (0.05, 0.16)
0.11 (0.06, 0.19)
0.14 (0.09, 0.22)
0.15 (0.10, 0.24)
Is participation at 68–69 years affected by recent health status?
Having three or more clinical disorders at age 60–64 was associated with lower overall and home visit participation at age 68–69 but there was no difference in participation comparing those with fewer or no clinical disorders (Table 1). Those rating their general health as poor or fair at age 68 were less likely to have a home visit at age 69 (66 and 78% respectively) compared with those reporting that their health was good (85%), very good (89%) or excellent (88%). Those who reported a longstanding illness which limited activities were slightly less likely to have a home visit (83%) than those reporting no illness (86%) while those reporting a longstanding illness which was not limiting had the highest home visit participation (88%). Similarly, there was a tendency for those with milder symptoms or one or two falls to have higher participation than those with no incontinence, chronic pain or falls. Otherwise there were no associations, and no further analyses were conducted with these symptoms or falls.
Odds ratios (95% confidence intervals) of overall and home visit participation at 68–69 years by recent health status
Odds ratio (95% confidence intervals)
Overall participation (n = 1791)
Home visit participation (n = 1662)
No. clinical disorders at 60–64 years
0.48 (0.18, 1.3)
0.54 (0.20, 1.4)
0.46 (0.26, 0.79)
0.56 (0.32, 0.98)
0.60 (0.34, 1.0)
0.45 (0.23, 0.88)
0.51 (0.26, 1.0)
0.52 (0.35, 0.76)
0.57 (0.39, 0.84)
0.65 (0.44, 0.97)
Self-rated health at 68 years
Excellent, very good, good
Fair or poor
0.40 (0.27, 0.59)
0.45 (0.30, 0.67)
0.53 (0.35, 0.79)
0.30 (0.03, 2.7)
0.32 (0.03, 2.9)
0.27 (0.03, 2.6)
Is participation at 68–69 years affected by previous clinical feedback?
Overall and home visit participation at 68–69 years by clinical feedback at 60–64 years and prior study engagement
Variable (maximum sample for overall/home visit participation)
Home visit participation
No. participants/maximum sample
No. participants/maximum sample
Clinical feedback at age 60–64
Letter for blood test results (n = 2072/2022)a
Actionable blood results
Results outside normal range
All results within normal range
Letter for plaque or abnormal echocardiogram (n = 1646/1615)b
Letter for bone density imaging (n = 1646/1615)b
Yes, osteoporosis threshold
Yes, osteopenia threshold
Prior study engagement
Letter to study members in response to queries at age 60–64 (n = 2731/2624)c
Attended 65th birthday party and/or provide memories about the study (n = 2156/2104)d
Willing to do take part in public events or speak to media (n = 2816/2698)
Odds ratios (95% confidence intervals) of overall and home visit participation at 68–69 years by indicators of clinical feedback and study engagement
Odds ratio (95% confidence intervals)
Home visit participation
Actionable blood test results at 60–64 years (yes vs. no)
0.47 (0.25, 0.91)
0.49 (0.26, 0.95)
0.46 (0.23, 0.89)
0.63 (0.41, 0.96)
0.65 (0.42, 1.0)
0.67 (0.42, 1.0)
Letter to study member in response to queries at 60–64 years (yes vs. no)
1.5 (0.88, 2.6)
1.3 (0.72, 2.2)
0.93 (0.51, 1.7)
1.5 (1.1, 2.2)
1.3 (0.92, 1.9)
1.1 (0.71, 1.6)
Attended 65th birthday party and/or provided memories (yes vs. no)
2.7 (1.1, 6.3)
2.1 (0.88, 5.1)
1.9 (0.77, 4.5)
4.1 (2.4, 7.0)
3.1 (1.8, 5.4)
2.8 (1.6, 4.9)
Willing to take part in public events or speak to media (yes vs. no)
8.1 (2.0, 33.1)
5.2 (1.3, 21.3)
2.9 (0.68, 12.0)
11.7 (4.3, 31.8)
8.4 (3.1, 22.8)
5.1 (1.9, 14.3)
Is participation at 68–69 years affected by previous study engagement?
Over one in ten (11%) received letters from the study director in response to their queries or comments at age 60–64; this group had higher participation rates at age 68–69 (Table 4). One in five (22%) took up the invitation to attend one of the four parties held to celebrate their 65th birthday or provided memories of being in the study, and 7% offered to take part in public events or be interviewed by the media. All these indicators of study engagement were associated with higher participation rates (Table 4). Being in a non-manual occupational class, and having higher educational qualifications and childhood cognitive ability were all associated with having queries or making comments requiring a special letter, or engaging in study social activities (p < 0.001). Having three or more clinical disorders at age 60–64 and fair or poor self-rated health at age 68 were associated with engaging less in study social activities (both p < 0.001), and with receiving a letter in response to a query (self-rated health only, p = 0.02).
Strong associations between taking part in 65th birthday activities or being willing to take part in public events or speak to the media and home visit participation remained, albeit attenuated, after adjusting for sex and lifetime contact (Table 5, model 1), then for socioeconomic and cognitive characteristics (model 2), and finally for recent health status (model 3b). The associations with overall participation were weaker. The associations between receiving a letter in response to a query and participation rates were slightly weaker in the sample with complete socioeconomic and cognitive data and were no longer associated with participation once all confounders were included in the model (Table 5, all models).
Future participation and satisfaction
Of those completing a home visit, 98% expressed a preference to remain in the study should they lose capacity to give consent. Of those sent an evaluation form that was enclosed with their results letter, 72% were returned; 98% of these participants were very satisfied (89%) or satisfied (9%) with the visit overall.
Participation in the 24th NSHD data collection at age 68–69 years was high; the postal questionnaire, nurse visit and overall participation rates (84, 80, 94%, respectively) for those living in Great Britain were even higher than the equivalent rates achieved at 60–64 years (81, 78, 84%). Ways we sought to achieve these rates were based on study members’ response at previous contacts. Being representative of the post war generation, study members appreciate annual birthday cards to maintain contact, the initial approach at each follow-up by formal letter, the style of any telephone or email contact, the personal approach we take to responding to queries, or to clinically relevant findings, and our efforts at accommodating their preferences in arranging visits, even where this has extended the fieldwork period. The team has experience in how many postal reminders or telephone calls achieve the best results, and the acceptable length of questionnaires and visits. With their consent, we feed forward information so that participants are not repeatedly asked certain questions (e.g. about parental death) if such information is already known.
Despite our concerns, there was no evidence that the pioneering clinic data collection at 60–64 years lowered future response for those attending the clinic—indeed evidence suggested the opposite. However, the increasingly biomedical nature of the data collections may deter some people from participating; we plan to ask if that was the case for those only completing postal questionnaires or not participating in the recent sweep (while remaining in the study). Our findings suggest these two groups need particular attention to encourage participation and avoid permanent withdrawal at a future sweep.
Despite the high overall and home visit participation rates, 25% of those who provided some information did not complete both the postal questionnaire and the home visit, and variables derived from several questions (such as some of the health status variables) also have item missing data. Missing data are problematic: one strategy for reducing missing data for participants who did not complete a postal questionnaire but did have a home visit was to feed forward essential questions not answered on the postal questionnaire onto the computer assisted nurse interview. In addition, where possible, nurses returned to complete clinical assessments that for reasons, such as faulty equipment, were not collected during the first visit (2%). The short questionnaire sent to those unable or unwilling to have a visit also captured missing information.
Missing data at previous sweeps is also a challenge for testing life course hypotheses. While NSHD has a high rate of continuous participation with over two-thirds of study members having missed no more than 2 out of 23 previous data sweeps, there is a group who come in and out of the study. Reasons for this include addresses not being kept up to date in previous years and study members living abroad for a period. The information presented indicates that careful tracing is worthwhile—between the two sweeps at age 60–64 and age 68–69, 159 study members returned and their overall and home visit participation rates were reasonably high. Recognising the presence of this group is important and requires careful consideration as many methods for dealing with losses to follow-up assume that losses are permanent.
At this latest follow-up there were no gender differences in overall participation rates; this is a change from previous NSHD follow-ups in adulthood where men have been less likely to participate [13, 24, 25]. This may be due to men becoming more willing to participate as they get older and possibly as a result of having more time after retirement. Alternatively, there may be more survival bias in men than women; 20% of men (n = 568) compared with 15% of women (n = 389) were not contacted for this latest data collection because they were already deceased.
In a long-term study, such as a birth cohort, higher levels of lifetime and recent contact are very informative about future participation, yet with few exceptions,  little attention is paid to prior contact in the literature on attrition in longitudinal studies. These variables mediated at least some of the socioeconomic and cognitive characteristics consistently shown to affect attrition.
Recent health status, clinical feedback and participation
Recent health status was associated with participation rates, particularly the home visit. This becomes more of a problem as a birth cohort study matures into older ages and morbidity becomes widespread. At age 53, there was little evidence that health status was a key reason for low participation . However the evidence from NSHD indicated that multi-morbidity by early old age and self-rated general ill-health had particularly adverse effects on participation. In contrast, there was no evidence that mild health symptoms affected participation—if anything the opposite. These findings suggest that distinguishing multi-morbidity or severe ill-health from less severe forms of ill-health may shed light on inconsistent associations between health status and attrition in longitudinal studies [17, 18, 19].
It was reassuring that feedback about clinically relevant results from cardiovascular and bone assessments that required further follow-up had no effect on future participation. While reporting of non-urgent blood results was not associated with subsequent participation, the reporting of actionable blood results was associated with reduced subsequent participation and this finding was only partially explained by socioeconomic, cognitive or health characteristics. This was not due to excess deaths as we only followed up those in the target sample at 68–69 years. Almost half of the actionable blood results were abnormal on a liver function test, which may have led to GPs recommending lifestyle or medication changes that were not appreciated. However, this is speculative as we were not able to collect information on how these results were followed up by the study members and their GPs.
Study engagement and participation
In the last 6 years, it has been a major departure for the study team to provide opportunities for participants to meet each other and to invite them to share memories of the study and be involved in public and media events. We had to balance the risks of these activities having effects on life trajectories, or individuals regretting being identified as study members, against the benefits of feeling appreciated for their lifelong commitment. We had numerous requests from study members to celebrate key birthdays, and the birthday celebrations at age 65 were very well received,  as were the recent ones held to mark the 70th birthday. They also led to a much greater profile for the study (http://www.bbc.co.uk/news/uk-35699088). Our findings suggest that these types of activities are associated with higher subsequent participation even after allowing for the fact that those who take part, on average, have better socioeconomic circumstances, higher cognitive ability and better health. However, this evidence is not conclusive as there was no experimental design embedded in these engagement activities.
Lessons learnt for maintaining participation into older age
We will use these findings to help the team to design the best ways to maintain future contact, and make subsequent home or clinic visits comfortable for those with multi-morbidity or those who generally prefer to complete postal questionnaires. We anticipate that there will be an important role for highly skilled research nurses attached to the study team to undertake the visits with participants who are vulnerable in terms of physical, mental or emotional capacity and who will accommodate individual needs of these study members (such as several short visits, or taking time to engage the participant and go at their pace). Increasing cognitive impairment will require more use of our protocols for those who no longer have the capacity to give consent, if their participation is to be retained. In NSHD, those lost many years ago are particularly hard to trace, so it is important to undertake tracing exercises at the earliest opportunity when a study member is first lost to follow-up.
In conclusion, evidence from this 70 year old birth cohort study shows that participation can remain high even when participants enter their seventh decade. This takes effort by the study team as participation rates appear to be favourably influenced by strategies that are tailored to appeal to their age, cohort, individual capacities and preferences. Activities that foster study engagement appear to be beneficial for subsequent participation.
We thank NSHD study members who took part in the 24th data collection for their continuing support. The authors are grateful to Dr Stella Muthuri and Dr Alex Tsui who provided newly derived variables used in the analyses and Dr Stephanie Pilling who helped prepare the manuscript. We also thank Dr Nancy W Glynn and Dr Adam Santanasto of the University of Pittsburgh for their advice in using the Pittsburgh Fatigability Scale. We thank the team at Kantar Public (formerly known as TNS BMRB) and Medicals Direct Group (MDG) for their work in project development, management of the nurse field-force and data collection and delivery; and the nurses themselves who showed such dedication and commitment to the study.
This work was supported by the UK Medical Research Council which provides core funding for the MRC National Survey of Health and Development and DK, RH, MR, RC, MS, NS, AW, PC, MP, AM by MC_UU_12019/1. Daniel Davis is supported by a Wellcome Trust Intermediate Clinical Fellowship (WT107467). Data used in this publication are available to bona fide researchers upon request to the NSHD Data Sharing Committee via a standard application procedure. Further details can be found at http://www.nshd.mrc.ac.uk/data. doi:10.5522/NSHD/Q102; 10.5522/NSHD/Q103.
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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