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European Journal of Epidemiology

, Volume 30, Issue 3, pp 189–196 | Cite as

Nut consumption and risk of stroke

  • Zhizhong Zhang
  • Gelin Xu
  • Yongyue Wei
  • Wusheng Zhu
  • Xinfeng Liu
META-ANALYSIS

Abstract

Nut consumption has been inconsistently associated with risk of stroke. Our aim was to carry out a meta-analysis of prospective studies to assess the relation between nut consumption and stroke risk and mortality. Pertinent studies were identified by a search of PubMed and Embase through June 2014 and by reviewing the references of retrieved articles. Prospective cohort studies that reported relative risks (RRs) with 95 % confidence intervals (CIs) for the association between nut consumption and risk of stroke were included. Six articles including nine independent prospective cohorts with 476,181 participants were included in the meta-analysis. The pooled RR of stroke was 0.90 (95 % CI 0.83–0.98) comparing the highest with the lowest nut consumption. Stratifying by gender, significant inverse association was observed for females (RR 0.88; 95 % CI 0.78–0.98). Sensitivity analysis restricted to studies with adjustment for common confounding factors showed similar results, strengthening the association between nut consumption and stroke risk. Moreover, we observed a trend toward an inverse association between higher nut consumption and stroke mortality (RR 0.86; 95 % CI 0.69–1.06), although it is not significant. Current evidence indicated that nut consumption is inversely associated with risk of stroke.

Keywords

Nut Stroke Prospective studies 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Zhizhong Zhang
    • 1
  • Gelin Xu
    • 1
  • Yongyue Wei
    • 2
  • Wusheng Zhu
    • 1
  • Xinfeng Liu
    • 1
  1. 1.Department of Neurology, Jinling HospitalMedical School of Nanjing UniversityNanjingChina
  2. 2.Department of Environmental Health, Harvard School of Public HealthHarvard UniversityBostonUSA

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