Breast cancer risk and night shift work in a case–control study in a Spanish population
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Epidemiologic and animal data indicate that night shift work might increase the risk for breast cancer. We evaluated the association of night work with different clinical types of breast cancer in a population based case–control study (MCC-Spain study) taking into account chronotype, an individual characteristic that may relate to night shift work adaptation. Lifetime occupational history was assessed by face-to-face interviews and shift work information was available for 1708 breast cancer cases and 1778 population controls from 10 Spanish regions, enrolled from 2008 to 2013. We evaluated three shift work domains, including shift work type (permanent vs rotating), lifetime cumulative duration and frequency. We estimated odds ratios (OR) for night work compared to day work using unconditional logistic regression models adjusting for confounders. Having ever worked permanent or rotating night shift was associated with an increased risk for breast cancer compared to day workers [odds ratio (OR) 1.18; 95 % CI 0.97, 1.43]. Chronotype was differentially associated with breast cancer depending on the duration of night shift work. Risk was higher in women with invasive tumors (OR 1.23; 95 % CI 1.00, 1.51) and for estrogen and progestagen positive tumors among premenopausal women (OR 1.44; 95 % CI 1.05, 1.99). Having ever performed night shift was associated with a small increased risk for breast cancer and especially in subgroups of women with particular hormone related characteristics.
KeywordsBreast cancer Circadian disruption Night shift
We would like to acknowledge the participants in the study, the data manager and all the interviewers and technicians involved in the data collection. We would also like to thank Juan Alguacil, Miguel Santibañez, Victor Moreno and Laura Costas for their valuable comments in the text.
The study was funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the European Commission Grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government DURSI Grant 2009SGR1489, and by a predoctoral Grant PFIS (FI09/00385).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Research involving human participants
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 3.Bonde JP, Hansen J, Kolstad HA, Mikkelsen S, Olsen JH, Blask DE, Harma M, Kjuus H, de Koning HJ, Olsen J, Moller M, Schernhammer ES, Stevens RG, Akerstedt T. Work at night and breast cancer-report on evidence-based options for preventive actions. Scand J Work Environ Health. 2012;38(4):380–90.CrossRefPubMedGoogle Scholar
- 5.IARC. Painting, firefighting and shiftwork. IARC Monogr. 2010;98:561–764.Google Scholar
- 10.Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, Castano-Vinyals G, Davis S, Frings-Dresen MH, Fritschi L, Kogevinas M, Kogi K, Lie JA, Lowden A, Peplonska B, Pesch B, Pukkala E, Schernhammer E, Travis RC, Vermeulen R, Zheng T, Cogliano V, Straif K. Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC working group report. Occup Environ Med. 2010;68(2):154–62.CrossRefPubMedGoogle Scholar
- 16.Yang XR, Sherman ME, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Anderson WF, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, Garcia-Closas M. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev. 2007;16(3):439–43.CrossRefPubMedGoogle Scholar
- 19.Castano-Vinyals G, Aragones N, Perez-Gomez B, Martin V, Llorca J, Moreno V, Altzibar JM, Ardanaz E, de Sanjose S, Jimenez-Moleon JJ, Tardon A, Alguacil J, Peiro R, Marcos-Gragera R, Navarro C, Pollan M, Kogevinas M. Population-based multicase–control study in common tumors in Spain (MCC-Spain): rationale and study design. Gac Sanit. 2015;29(4):308–15.CrossRefPubMedGoogle Scholar
- 22.Fritschi L, Erren TC, Glass DC, Girschik J, Thomson AK, Saunders C, Boyle T, El-Zaemey S, Rogers P, Peters S, Slevin T, D’Orsogna A, de Vocht F, Vermeulen R, Heyworth JS. The association between different night shiftwork factors and breast cancer: a case–control study. Br J Cancer. 2013;109(9):2472–80.CrossRefPubMedPubMedCentralGoogle Scholar
- 26.Pesch B, Harth V, Rabstein S, Baisch C, Schiffermann M, Pallapies D, Bonberg N, Heinze E, Spickenheuer A, Justenhoven C, Brauch H, Hamann U, Ko Y, Straif K, Bruning T. Night work and breast cancer—results from the German GENICA study. Scand J Work Environ Health. 2010;36(2):134–41.CrossRefPubMedGoogle Scholar
- 36.Rabstein S, Harth V, Pesch B, Pallapies D, Lotz A, Justenhoven C, Baisch C, Schiffermann M, Haas S, Fischer HP, Heinze E, Pierl C, Brauch H, Hamann U, Ko Y, Bruning T. Night work and breast cancer estrogen receptor status–results from the German GENICA study. Scand J Work Environ Health. 2013;39(5):448–55.CrossRefPubMedGoogle Scholar
- 37.Terry PD, Rohan TE. Cigarette smoking and the risk of breast cancer in women: a review of the literature. Cancer Epidemiol Biomark Prev. 2002;11(10 Pt 1):953–71.Google Scholar