European Journal of Epidemiology

, Volume 29, Issue 12, pp 929–936 | Cite as

The Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) project—design, population and data harmonization of a large-scale, international study

  • Paolo Boffetta
  • Martin Bobak
  • Axel Borsch-Supan
  • Hermann Brenner
  • Sture Eriksson
  • Fran Grodstein
  • Eugene Jansen
  • Mazda Jenab
  • Hendrik Juerges
  • Ellen Kampman
  • Frank Kee
  • Kari Kuulasmaa
  • Yikyung Park
  • Anne Tjonneland
  • Cornelia van Duijn
  • Tom Wilsgaard
  • Alicja Wolk
  • Dimitrios Trichopoulos
  • Christina Bamia
  • Antonia TrichopoulouEmail author


There is a public health demand to prevent health conditions which lead to increased morbidity and mortality among the rapidly-increasing elderly population. Data for the incidence of such conditions exist in cohort studies worldwide, which, however, differ in various aspects. The Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) project aims at harmonizing data from existing major longitudinal studies for the elderly whilst focussing on cardiovascular diseases, diabetes mellitus, cancer, fractures and cognitive impairment in order to estimate their prevalence, incidence and cause-specific mortality, and identify lifestyle, socioeconomic, and genetic determinants and biomarkers for the incidence of and mortality from these conditions. A survey instrument assessing ageing-related conditions of the elderly will be also developed. Fourteen cohort studies participate in CHANCES with 683,228 elderly (and 150,210 deaths), from 23 European and three non-European countries. So far, 287 variables on health conditions and a variety of exposures, including biomarkers and genetic data have been harmonized. Different research hypotheses are investigated with meta-analyses. The results which will be produced can help international organizations, governments and policy-makers to better understand the broader implications and consequences of ageing and thus make informed decisions.


Cohort Ageing Elderly Meta-analysis 



The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007–2013) DG-RESEARCH under Grant Agreement No. HEALTH—F3-2010-242244.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Paolo Boffetta
    • 1
    • 2
  • Martin Bobak
    • 3
  • Axel Borsch-Supan
    • 4
  • Hermann Brenner
    • 5
  • Sture Eriksson
    • 6
  • Fran Grodstein
    • 7
  • Eugene Jansen
    • 8
  • Mazda Jenab
    • 9
  • Hendrik Juerges
    • 10
  • Ellen Kampman
    • 11
  • Frank Kee
    • 12
  • Kari Kuulasmaa
    • 13
  • Yikyung Park
    • 14
  • Anne Tjonneland
    • 15
  • Cornelia van Duijn
    • 16
  • Tom Wilsgaard
    • 17
  • Alicja Wolk
    • 18
  • Dimitrios Trichopoulos
    • 1
    • 19
    • 20
  • Christina Bamia
    • 1
    • 21
  • Antonia Trichopoulou
    • 1
    • 21
    Email author
  1. 1.Hellenic Health FoundationAthensGreece
  2. 2.Institute for Translational Epidemiology and Tisch Cancer InstituteIcahn School of Medicine at Mount SinaiNew YorkUSA
  3. 3.Department of Epidemiology and Public HealthUniversity College LondonLondonUK
  4. 4.Munich Center for the Economics of AgingMax-Planck Institute for Social Law and Social PolicyMunichGermany
  5. 5.Division of Clinical Epidemiology and Aging ResearchGerman Cancer Research CenterHeidelbergGermany
  6. 6.Geriatric MedicineUmeå UniversityUmeåSweden
  7. 7.Channing Division of Network MedicineBrigham and Women’s HospitalBostonUSA
  8. 8.Centre for Health ProtectionNational Institute for Public Health and the EnvironmentBilthovenThe Netherlands
  9. 9.International Agency for Research on Cancer (IARC-WHO)LyonFrance
  10. 10.Schumpeter School of Business and EconomicsUniversity of WuppertalWuppertalGermany
  11. 11.Division of Human NutritionWageningen UniversityWageningenThe Netherlands
  12. 12.UKCRC Centre of Excellence for Public Health (Northern Ireland), Institute of Clinical SciencesQueens UniversityBelfastNorthern Ireland, UK
  13. 13.Chronic Disease Epidemiology and Prevention UnitNational Institute for Health and Welfare (THL)HelsinkiFinland
  14. 14.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  15. 15.Danish Cancer Society Research CenterCopenhagen ØDenmark
  16. 16.Department of EpidemiologyErasmus University Medical CenterRotterdamThe Netherlands
  17. 17.Department of Community MedicineUIT The Arctic University of NorwayTromsöNorway
  18. 18.Institute of Environmental MedicineKarolinska InstitutetStockholmSweden
  19. 19.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  20. 20.Bureau of Epidemiologic ResearchAcademy of AthensAthensGreece
  21. 21.Department of Hygiene, Epidemiology and Medical StatisticsUniversity of Athens Medical SchoolAthensGreece

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