Oxidative stress and inflammation are major contributors to accelerated age-related relative telomere length (RTL) shortening. Both conditions are strongly linked to leptin and adiponectin, the most prominent adipocyte-derived protein hormones. As high leptin levels and low levels of adiponectin have been implicated in inflammation, one expects adiponectin to be positively associated with RTL while leptin should be negatively associated. Within the ENGAGE consortium, we investigated the association of RTL with adiponectin and leptin in seven independent cohorts with a total of 11,448 participants. We performed partial correlation analysis on Z-transformed RTL and LN-transformed leptin/adiponectin, adjusting for age and sex. In extended models we adjusted for body mass index (BMI) and C-reactive protein (CRP). Adiponectin showed a borderline significant association with RTL. This appeared to be determined by a single study and when the outlier study was removed, this association disappeared. The association between RTL and leptin was highly significant (r = −0.05; p = 1.81 × 10−7). Additional adjustment for BMI or CRP did not change the results. Sex-stratified analysis revealed no difference between men and women. Our study suggests that high leptin levels are associated with short RTL.
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The study was supported by grants from The Netherlands Organisation for Scientific Research (NWO), Erasmus MC, the Centre for Medical Systems Biology (CMSB), The European Community’s Seventh Framework Programme (FP7/2007–2013), ENGAGE Consortium, Grant agreement HEALTH-F4-2007- 201413 and Netherlands Consortium for Healthy Ageing (Grant 050-060-810). We are grateful to all general practitioners for their contributions, to Petra Veraart for her help in genealogy, Jeannette Vergeer for the supervision of the laboratory work and Peter Snijders for his help in data collection.
The KORA studies were financed by the Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany and supported by Grants from the German Federal Ministry of Education and Research (BMBF). Part of this work was financed by the German National Genome Research Network (NGFN; NGFNPlus, project number 01GS0834) and supported within the Munich Center of Health Sciences (MC Health) as part of LMUinnovativ. Telomere assays were funded by the ENGAGE consortium. This study was supported in part by a Grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.). The measurement of adiponectin in KORA F3 was partially funded by the “Tiroler Wissenschaftsfonds” (Project UNI-0407/29) and by the “Genomics of Lipid-associated Disorders—GOLD” of the “Austrian Genome Research Programme GEN-AU” to F. Kronenberg. We appreciate the technical assistance of Barbara Luhan.
We thank all participants of the Leiden Longevity Study. The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007–2011) under Grant agreement no 259679. This study was supported by a Grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, and the Netherlands Consortium for Healthy Ageing (Grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO), and by Unilever Colworth.
The study was funded by the Wellcome Trust; European Community’s Seventh Framework Programme (FP7/2007–2013), ENGAGE project grant agreement (HEALTH-F4-2007-201413). The study also receives support from the Dept of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. TDS is an NIHR senior Investigator and is holder of an ERC Advanced Principal Investigator award. Genotyping was performed by The Wellcome Trust Sanger Institute, support of the National Eye Institute via an NIH/CIDR genotyping project.
The measurement of telomere length in the SAPHIR-study was funded by the Austrian Heart Fund to F. Kronenberg. The SAPHIR-study was partially supported by a grant from the Kamillo-Eisner Stiftung, Salzburger Forschungsgesellschaft, Oesterreichische Nationalbank (OeNB Nr. 13339) and the Paracelsus Medical University (FFF-PMU Nr. E-09/09/055-PAU) to B. Paulweber.
The study was supported by Helsinki University Hospital Research Funds, grants from Novo Nordisk, Diabetes Research Foundation, Finnish Foundation for Cardiovascular Research, Biomedicum Helsinki, Jalmari and Rauha Ahokas Foundation, and the Academy of Finland Centre of Excellence in Complex Disease Genetics. Data collection in FinnTwin16 and FinnTwin12 were supported by the National Institute of Alcohol Abuse and Alcoholism (Grants AA-12502 and AA-09203 to Richard J Rose), and the Academy of Finland (grants 44069, 205585, 118555, 141054 to JK) and by the EU funded projects TORNADO (FP7-KBBE-22270) and ENGAGE (FP7-HEALTH-F4-2007).
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