European Journal of Epidemiology

, Volume 29, Issue 8, pp 577–584

Night work and breast cancer risk in a general population prospective cohort study in The Netherlands

  • Lando L. J. Koppes
  • Goedele A. Geuskens
  • Anjoeka Pronk
  • Roel C. H. Vermeulen
  • Ernest M. M. de Vroome
CANCER

Abstract

Experimental studies in animals indicate that disruption of the circadian rhythm is carcinogenic, and night work has been suggested to be a probable breast cancer cause in humans. Findings among humans, however are inconsistent, often gathered with retrospective study designs, and only based on specific populations, such as nurses. We used data on night work collected in the Dutch Labor Force Surveys of 1996 until 2009, and individually linked these with National registers on hospital admission. Among 285,723 women without breast cancer at baseline, 2,531 had a hospital admission for breast cancer during an average of 7 years of follow up in the registers. Occasional and regular night work were not associated with the risk of hospital admission for breast cancer (adjusted hazard ratios 1.04; 95 % confidence interval 0.85–1.27, and 0.87; 0.72–1.05, respectively). Working more hours per week, or more years in a job entailing night work did not show increased breast cancer risks. Hazard ratios neither differed between nurses and women with other occupations. Our results show no association of night work with incident breast cancer, and suggest that night work generally does not increase the risk of breast cancer among women in the Dutch working population.

Keywords

Breast cancer General population Night work Nurses Prospective cohort Record linkage 

References

  1. 1.
    Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, et al. Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol. 2007;8(12):1065–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Costa G, Haus E, Stevens R. Shift work and cancer: considerations on rationale, mechanisms, and epidemiology. Scand J Work Environ Health. 2010;36(2):163–79.PubMedCrossRefGoogle Scholar
  3. 3.
    Eurofound. Fifth European Working Conditions Survey. Luxembourg: Publications Office of the European Union; 2012.Google Scholar
  4. 4.
    Kolstad HA. Nightshift work and the risk of breast cancer and other cancers: a critical review of the epidemiological evidence. Scand J Work Environ Health. 2008;34(1):5–22.PubMedCrossRefGoogle Scholar
  5. 5.
    Ijaz S, Verbeek J, Seidler A, Lindbohm ML, Ojajärvi A, Orsini N, et al. Night-shift work and breast cancer: a systematic review and meta-analysis. Scand J Work Environ Health. 2013;39(5):431–47.PubMedCrossRefGoogle Scholar
  6. 6.
    Jia Y, Lu Y, Wu K, Lin Q, Shen W, Zhu M, et al. Does night work increase the risk of breast cancer? A systematic review and meta-analysis of epidemiological studies. Cancer Epidemiol. 2013;37(3):197–206.PubMedCrossRefGoogle Scholar
  7. 7.
    Kamdar BB, Tergas AI, Mateen FJ, Bhayani NH, Oh J. Night-shift work and risk of breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat. 2013;138(1):291–301.PubMedCrossRefGoogle Scholar
  8. 8.
    Wang F, Yeung KL, Chan WC, Kwok CC, Leung SL, Wu C, et al. A meta-analysis on dose–response relationship between night shift work and the risk of breast cancer. Ann Oncol. 2013;24(11):2724–32.PubMedCrossRefGoogle Scholar
  9. 9.
    Bonde JP, Hansen J, Kolstad HA, Mikkelsen S, Olsen JH, Blask DE, et al. Work at night and breast cancer: report on evidence-based options for preventive actions. Scand J Work Environ Health. 2012;38(4):380–90.PubMedCrossRefGoogle Scholar
  10. 10.
    Knutsson A, Alfredsson L, Karlsson B, Akerstedt T, Fransson EI, Westerholm P, et al. Breast cancer among shift workers: results of the WOLF longitudinal cohort study. Scand J Work Environ Health. 2013;39(2):170–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Pronk A, Ji BT, Shu XO, Xue S, Yang G, Li HL, et al. Night-shift work and breast cancer risk in a cohort of Chinese women. Am J Epidemiol. 2010;171(9):953–9.PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, et al. Rotating night shifts and risk of breast cancer in women participating in the Nurses’ Health Study. J Natl Cancer Inst. 2001;93(20):1563–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Schernhammer ES, Kroenke CH, Laden F, Hankinson SE. Night work and risk of breast cancer. Epidemiology. 2006;17(1):108–11.PubMedCrossRefGoogle Scholar
  14. 14.
    Girschik J, Heyworth J, Fritschi L. Response to: night-shift work and breast cancer risk in a cohort of Chinese women. Am J Epidemiol. 2010;172(7):865–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Fritschi L, Erren TC, Glass DC, Girschik J, Thomson AK, Saunders C, et al. The association between different night shiftwork factors and breast cancer: a case–control study. Br J Cancer. 2013;109(9):2472–80.PubMedCrossRefGoogle Scholar
  16. 16.
    Lie JA, Kjuus H, Zienolddiny S, Haugen A, Stevens RG, Kjærheim K. Night work and breast cancer among Norwegian nurses: assessment by different exposure metrics. Am J Epidemiol. 2011;173(11):1272–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Hansen J, Stevens RG. Case–control study of shift-work and breast cancer risk in Danish nurses: impact of shift systems. Eur J Cancer. 2012;48(11):1722–9.PubMedCrossRefGoogle Scholar
  18. 18.
    Klein Hesselink J, de Leede J, Goudswaard A. Effects of the new fast forward rotating five-shift roster at a Dutch steel company. Ergonomics. 2010;53(6):727–38.PubMedCrossRefGoogle Scholar
  19. 19.
    Sallinen M, Kecklund G. Shift work, sleep, and sleepiness: differences between shift schedules and systems. Scand J Work Environ Health. 2010;36(2):121–33.PubMedCrossRefGoogle Scholar
  20. 20.
    Teichgraber M. European Union Labour Force Survey: annual results 2011. In: Eurostat Statistics in focus 40/2012. European Union. 2012. http://epp.eurostat.ec.europa.eu/cache/ITY_OFFPUB/KS-SF-12-040/EN/KS-SF-12-040-EN.PDF. Accessed 4 July 2014.
  21. 21.
    Stevens RG, Hansen J, Costa G, Haus E, Kauppinen T, Aronson KJ, et al. Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report. Occup Environ Med. 2011;68(2):154–62.PubMedCrossRefGoogle Scholar
  22. 22.
    Wang X-S, Travis RC, Reeves G, Green J, Allen NE, Key TJ, et al. Characteristics of the Million Women Study participants who have and have not worked at night. Scand J Work Environ Health. 2012;38(6):590–9.PubMedCrossRefGoogle Scholar
  23. 23.
    Veronesi U, Boyle P, Goldhirsch A, Orecchia R, Viale G. Breast cancer. Lancet. 2005;365(9472):1727–41.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Lando L. J. Koppes
    • 1
  • Goedele A. Geuskens
    • 1
  • Anjoeka Pronk
    • 2
  • Roel C. H. Vermeulen
    • 3
  • Ernest M. M. de Vroome
    • 1
  1. 1.Division Work, Health and CareNetherlands Organization for Applied Scientific Research (TNO)HoofddorpThe Netherlands
  2. 2.Division Quality and SafetyNetherlands Organization for Applied Scientific Research (TNO)ZeistThe Netherlands
  3. 3.Division Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS)Utrecht UniversityUtrechtThe Netherlands

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