Advertisement

European Journal of Epidemiology

, Volume 29, Issue 9, pp 613–619 | Cite as

Dairy foods intake and risk of Parkinson’s disease: a dose–response meta-analysis of prospective cohort studies

  • Wenjie Jiang
  • Chuanxia Ju
  • Hong Jiang
  • Dongfeng Zhang
META-ANALYSIS

Abstract

Dairy foods have been linked to Parkinson’s disease (PD), and a meta-analysis of prospective cohort studies on dairy foods intake and PD risk was conducted. Eligible studies were identified in a literature search of EMBASE and PubMed up to April 2014. Seven results from prospective studies were included, including 1,083 PD cases among 304,193 subjects. The combined risk of PD for highest vs. lowest level of dairy foods intake was 1.40 (1.20–1.63) overall, 1.66 (1.29–2.14) for men and 1.15 (0.85–1.56) for women. For highest vs. lowest level, the PD risk was 1.45 (1.23–1.73) for milk, 1.26 (0.99–1.60) for cheese, 0.95 (0.76–1.20) for yogurt and 0.76 (0.51–1.13) for butter. The linear dose–response relationship showed that PD risk increased by 17 % [1.17 (1.06–1.30)] for every 200 g/day increment in milk intake (Pfor non-linearity = 0.22), and 13 % [1.13 (0.91–1.40)] for every 10 g/day increment in cheese intake (Pfor non-linearity = 0.39). The absolute risk differences were estimated to be 2–4 PD cases per 100,000 person-years for every 200 g/day increment in milk intake, and 1–3 PD cases per 100,000 person-years for every 10 g/day increment in cheese intake. Dairy foods (milk, cheese) might be positively associated with increased risk of PD, especially for men.

Keywords

Dairy foods Parkinson’s disease Meta-analysis 

Notes

Acknowledgments

This study was sponsored by National Natural Science Foundation of China (No. 31371024), and Shandong Provincial science foundation (ZR2009CM112).

Conflict of interest

None.

Supplementary material

10654_2014_9921_MOESM1_ESM.doc (892 kb)
Supplementary material 1 (DOC 891 kb)

References

  1. 1.
    Wirdefeldt K, Adami HO, Cole P, Trichopoulos D, Mandel J. Epidemiology and etiology of Parkinson’s disease: a review of the evidence. Eur J Epidemiol. 2011;26(Suppl 1):S1–58.PubMedCrossRefGoogle Scholar
  2. 2.
    Hernan MA, Takkouche B, Caamano-Isorna F, Gestal-Otero JJ. A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson’s disease. Ann Neurol. 2002;52:276–84.PubMedCrossRefGoogle Scholar
  3. 3.
    Van Maele-Fabry G, Hoet P, Vilain F, Lison D. Occupational exposure to pesticides and Parkinson’s disease: a systematic review and meta-analysis of cohort studies. Environ Int. 2012;46:30–43.PubMedCrossRefGoogle Scholar
  4. 4.
    Choi HK, Liu S, Curhan G. Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2005;52:283–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Dalbeth N, Wong S, Gamble GD, et al. A cute effect of milk on serum urate concentrations: a randomised controlled crossover trial. Ann Rheum Dis. 2010;69:1677–82.PubMedCrossRefGoogle Scholar
  6. 6.
    Shen C, Guo Y, Luo W, Lin C, Ding M. Serum urate and the risk of Parkinson’s disease: results from a meta-analysis. Can J Neurol Sci. 2013;40:73–9.PubMedGoogle Scholar
  7. 7.
    Saaksjarvi K, Knekt P, Lundqvist A, et al. A cohort study on diet and the risk of Parkinson’s disease: the role of food groups and diet quality. Br J Nutr. 2013;109:329–37.PubMedCrossRefGoogle Scholar
  8. 8.
    Kyrozis A, Ghika A, Stathopoulos P, Vassilopoulos D, Trichopoulos D, Trichopoulou A. Dietary and lifestyle variables in relation to incidence of Parkinson’s disease in Greece. Eur J Epidemiol. 2013;28:67–77.PubMedCrossRefGoogle Scholar
  9. 9.
    Chen H, O’Reilly E, McCullough ML, et al. Consumption of dairy products and risk of Parkinson’s disease. Am J Epidemiol. 2007;165:998–1006.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Park M, Ross GW, Petrovitch H, et al. Consumption of milk and calcium in midlife and the future risk of Parkinson disease. Neurology. 2005;64:1047–51.PubMedCrossRefGoogle Scholar
  11. 11.
    Chen H, Zhang SM, Hernan MA, Willett WC, Ascherio A. Diet and Parkinson’s disease: a potential role of dairy products in men. Ann Neurol. 2002;52:793–801.PubMedCrossRefGoogle Scholar
  12. 12.
    Orsini N, Li R, Wolk A, Khudyakov P, Spiegelman D. Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. Am J Epidemiol. 2012;175:66–73.PubMedCrossRefPubMedCentralGoogle Scholar
  13. 13.
    Salem NM, Ahmad R, Estaitieh H. Organochlorine pesticide residues in dairy products in Jordan. Chemosphere. 2009;77:673–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Darko G, Acquaah SO. Levels of organochlorine pesticides residues in dairy products in Kumasi Ghana. Chemosphere. 2008;71:294–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Mallatou H, Pappas CP, Kondyli E, Albanis TA. Pesticide residues in milk and cheeses from Greece. Sci Total Environ. 1997;196:111–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Zgaga L, Theodoratou E, Kyle J, et al. The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PLoS One. 2012;7:e38123.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Wenjie Jiang
    • 1
  • Chuanxia Ju
    • 2
  • Hong Jiang
    • 3
  • Dongfeng Zhang
    • 1
  1. 1.Department of Epidemiology and Health StatisticsQingdao University Medical CollegeQingdaoPeople’s Republic of China
  2. 2.Department of PharmacologyQingdao University Medical CollegeQingdaoPeople’s Republic of China
  3. 3.Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines PhysiologyQingdao University Medical CollegeQingdaoPeople’s Republic of China

Personalised recommendations