European Journal of Epidemiology

, Volume 29, Issue 4, pp 285–292 | Cite as

Reduced risk of Parkinson’s disease associated with lower body mass index and heavy leisure-time physical activity

  • Katri Sääksjärvi
  • Paul Knekt
  • Satu Männistö
  • Jukka Lyytinen
  • Tuija Jääskeläinen
  • Noora Kanerva
  • Markku Heliövaara
NEUROEPIDEMIOLOGY

Abstract

The risk factors for Parkinson’s disease (PD) are not well established. We therefore examined the prediction of various lifestyle factors on the incidence of PD in a cohort drawn from the Finnish Mobile Clinic Health Examination Survey, conducted in 1973–1976. The study population comprised 6,715 men and women aged 50–79 years and free of PD at the baseline. All of the subjects completed a baseline health examination (including height and weight measurements) and a questionnaire providing information on leisure-time physical activity, smoking, and alcohol consumption. During a 22–year follow-up, 101 incident cases of PD occurred. The statistical analyses were based on Cox’s model including age, sex, education, community density, occupation, coffee consumption, body mass index (BMI), leisure-time physical activity, smoking and alcohol consumption as independent variables. At first, BMI was not associated with PD risk, but after exclusion of the first 15 years of follow-up, an elevated risk appeared at higher BMI levels (P for trend 0.02). Furthermore, subjects with heavy leisure-time physical activity had a lower PD risk than those with no activity [relative risk (RR) 0.27, 95 % confidence interval (CI) 0.08–0.90]. In variance with findings for other chronic diseases, current smokers had a lower PD risk than those who had never smoked (RR 0.23, 95 % CI 0.08–0.67), and individuals with moderate alcohol intake (at the level of <5 g/day) had an elevated PD risk compared to non-drinkers. The results support the hypothesis that lifestyle factors predict the occurrence of Parkinson’s disease, but more research is needed.

Keywords

Parkinson’s disease Cohort studies Body mass index Physical activity Smoking Alcohol 

Notes

Acknowledgments

The work of K Sääksjärvi was supported by a grant from Doctoral Programs in Public Health, funded by the Ministry of Education.

Conflict of interest

The authors have no conflict of interest to declare.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Katri Sääksjärvi
    • 1
  • Paul Knekt
    • 1
  • Satu Männistö
    • 2
  • Jukka Lyytinen
    • 3
  • Tuija Jääskeläinen
    • 1
  • Noora Kanerva
    • 2
  • Markku Heliövaara
    • 1
  1. 1.Department of Health, Functional Capacity and WelfareNational Institute for Health and WelfareHelsinkiFinland
  2. 2.Department of Chronic Disease PreventionNational Institute for Health and WelfareHelsinkiFinland
  3. 3.Department of NeurologyHelsinki University Central HospitalHelsinkiFinland

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