European Journal of Epidemiology

, Volume 29, Issue 2, pp 79–88

Dietary fiber intake and risk of type 2 diabetes: a dose–response analysis of prospective studies

  • Baodong Yao
  • Hong Fang
  • Wanghong Xu
  • Yujie Yan
  • Huilin Xu
  • Yinan Liu
  • Miao Mo
  • Hua Zhang
  • Yanping Zhao
META-ANALYSIS

DOI: 10.1007/s10654-013-9876-x

Cite this article as:
Yao, B., Fang, H., Xu, W. et al. Eur J Epidemiol (2014) 29: 79. doi:10.1007/s10654-013-9876-x

Abstract

Observational studies suggest an association between dietary fiber intake and risk of type 2 diabetes, but the results are inconclusive. We conducted a meta-analysis of prospective studies evaluating the associations of dietary fiber intake and risk of type 2 diabetes. Relevant studies were identified by searching EMBASE (from 1974 to April 2013) and PubMed (from 1966 to April 2013). The fixed or random-effect model was selected based on the homogeneity test among studies. In addition, a 2-stage random-effects dose–response meta-analysis was performed. We identified 17 prospective cohort studies of dietary fiber intake and risk of type 2 diabetes involving 19,033 cases and 488,293 participants. The combined RR (95 % CI) of type 2 diabetes for intake of total dietary fiber, cereal fiber, fruit fiber and insoluble fiber was 0.81 (0.73–0.90), 0.77 (0.69–0.85), 0.94 (0.88–0.99) and 0.75 (0.63–0.89), respectively. A nonlinear relationship was found of total dietary fiber intake with risk of type 2 diabetes (Pfor nonlinearity < 0.01), and the RRs (95 % CI) of type 2 diabetes were 0.98 (0.90–1.06), 0.97 (0.87–1.07), 0.89 (0.80–0.99), 0.76 (0.65–0.88), and 0.66 (0.53–0.82) for 15, 20, 25, 30, and 35 g/day. The departure from nonlinear relationship was not significant (Pfor nonlinearity = 0.72), and the risk of type 2 diabetes decreased by 6 % (RR 0.94, 95 % CI 0.93–0.96) for 2 g/day increment in cereal fiber intake. Findings from this meta-analysis indicate that the intakes of dietary fiber may be inversely associated with risk of type 2 diabetes.

Keywords

Dietary fiber Type 2 diabetes Prospective studies Meta-analysis 

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Baodong Yao
    • 1
  • Hong Fang
    • 1
  • Wanghong Xu
    • 2
  • Yujie Yan
    • 1
  • Huilin Xu
    • 1
  • Yinan Liu
    • 1
  • Miao Mo
    • 2
  • Hua Zhang
    • 2
  • Yanping Zhao
    • 1
  1. 1.Shanghai Minhang Center for Disease Control and PreventionShanghaiChina
  2. 2.The Key Laboratory of Public Health Safety of Ministry of Education, Department of Epidemiology, School of Public HealthFudan UniversityShanghaiChina

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