High cystatin C levels predict severe retinopathy in type 2 diabetes patients
- 414 Downloads
Diabetes mellitus affects over 18.2 million people (or 6.3 % of the total population) in the US and over 800,000 new cases of type 2 diabetes are diagnosed every year . Meanwhile, diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes, resulting in blindness for over 10,000 people with diabetes per year . Cystatin C is a member of the cystatin superfamily of cystine protease inhibitors, which are produced by nucleated cells at a constant rate . Evidences have shown that serum cystatin C could predict early prognostic stages of diabetic nephropathy (DN)  and was implicated in the mechanism of age-related macular degeneration (AMD) . Charumathi et al. recently reported that elevated levels of serum cystatin C were associated with prediabetes in a nationally representative sample of non-obese US adults . In order to investigate the relationship between cystatin C and diabetic retinopathy (DR) to clarify the predictive value of...
KeywordsDiabetic Retinopathy Multiple Logistic Regression Analysis Diabetes Duration Serum Cystatin Postprandial Plasma Glucose
This work was supported by Grants (Nos. 81270397 and 81070650) from the Natural Science Foundation of China.
Conflict of interest
The authors declare that they have no conflict of interest.
- 5.Sabanayagam C, Wong TY, Xiao J, Shankar A. Serum cystatin C and prediabetes in non-obese US adults. European journal of epidemiology. 2013. doi: 10.1007/s10654-013-9781-3.