European Journal of Epidemiology

, Volume 28, Issue 7, pp 597–606 | Cite as

Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution’s impact on childhood asthma

  • Elaina A. MacIntyre
  • Christopher Carlsten
  • Meaghan MacNutt
  • Elaine Fuertes
  • Eric Melén
  • Carla M. T. Tiesler
  • Ulrike Gehring
  • Ursula Krämer
  • Claudia Klümper
  • Marjan Kerkhof
  • Moira Chan-Yeung
  • Anita L. Kozyrskyj
  • Dietrich Berdel
  • Carl Peter Bauer
  • Olf Herbarth
  • Mario Bauer
  • Beate Schaaf
  • Sibylle Koletzko
  • Goran Pershagen
  • Bert Brunekreef
  • Joachim Heinrich
  • Michael Brauer
NEW STUDY

Abstract

Associations between traffic-related air pollution and incident childhood asthma can be strengthened by analysis of gene-environment interactions, but studies have typically been limited by lack of study power. We combined data from six birth cohorts on: asthma, eczema and allergic rhinitis to 7/8 years, and candidate genes. Individual-level assessment of traffic-related air pollution exposure was estimated using land use regression or dispersion modeling. A total of 11,760 children were included in the Traffic, Asthma and Genetics (TAG) Study; 6.3 % reported physician-diagnosed asthma at school-age, 16.0 % had asthma at anytime during childhood, 14.1 % had allergic rhinitis at school-age, 10.0 % had eczema at school-age and 33.1 % were sensitized to any allergen. For GSTP1 rs1138272, the prevalence of heterozygosity was 16 % (range amongst individual cohorts, 11–17 %) and homozygosity for the minor allele was 1 % (0–2 %). For GSTP1 rs1695, the prevalence of heterozygosity was 45 % (40–48 %) and homozygosity for the minor allele, 12 % (10–12 %). For TNF rs1800629, the prevalence of heterozygosity was 29 % (25–32 %) and homozygosity for the minor allele, 3 % (1–3 %). TAG comprises a rich database, the largest of its kind, for investigating the effect of genotype on the association between air pollution and childhood allergic disease.

Keywords

Air pollution GSTP1 TNF Asthma Wheeze Gene-environment 

Abbreviations

APMoSPHERE

Air pollution modelling for support to policy on health and environmental risk in Europe

BAMSE

Children, allergy, Milieu, Stockholm, epidemiological survey

CAPPS

Canadian asthma primary prevention study

GINIplus

German infant study on the influence of nutritional intervention plus environmental and genetic influences on allergy development

GSTP1

Glutathione S-transferase pi 1

LISAplus

Lifestyle related factors, immune system and the development of allergies in East and West Germany plus the influence of traffic emissions and genetics study

LUR

Land-use regression

NO2

Nitrogen dioxide

O3

Ozone

PIAMA

Prevention and Incidence of asthma and mite allergy

PM2.5

Particulate matter of diameter less than 2.5 µm

SAGE

Study of asthma, genes, and environment

TAG

Traffic, asthma and genetics study

TNF

Tumour necrosis factor

TLR

Toll-like receptor

TRAP

Traffic-related air pollution

Supplementary material

10654_2013_9828_MOESM1_ESM.docx (41 kb)
Supplementary material 1 (DOCX 42 kb)

References

  1. 1.
    Health Effects Institute (2010) Traffic-related air pollution: a critical review of the literature on emissions, exposure and health effects: special report 17.Google Scholar
  2. 2.
    Braback L, Forsberg B. Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies. Environ Health. 2009;8:17.PubMedCrossRefGoogle Scholar
  3. 3.
    Brauer M, Hoek G, Smit HA, de Jongste JC, Gerritsen J, Postma DS, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007;29(5):879–88.PubMedCrossRefGoogle Scholar
  4. 4.
    Kim JJ, Smorodinsky S, Lipsett M, Singer BC, Hodgson AT, Ostro B. Traffic-related air pollution near busy roads: the East Bay Children’s Respiratory Health Study. Am J Respir Crit Care Med. 2004;170(5):520–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Salam MT, Islam T, Gilliland FD. Recent evidence for adverse effects of residential proximity to traffic sources on asthma. Curr Opin Pulm Med. 2008;14(1):3–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Brauer M, Hoek G, van Vliet P, Meliefste K, Fischer P, Gehring U, et al. Estimating long-term average particulate air pollution concentrations: application of traffic indicators and geographic information systems. Epidemiology. 2003;14(2):228–39.PubMedGoogle Scholar
  7. 7.
    Hoek G, Meliefste K, Cyrys J, Lewné M, Brauer M, Fischer P, et al. Spatial variability of fine particle concentrations in three European countries. Atmos Environ. 2002;36:4077–88.CrossRefGoogle Scholar
  8. 8.
    Allen RW, Amram O, Wheeler A, Brauer M. The transferability of NO and NO2 land use regression models between cities and pollutants. Atmos Environ. 2010;45:369–78.CrossRefGoogle Scholar
  9. 9.
    Henderson SB, Beckerman B, Jerrett M, Brauer M. Application of land use regression to estimate ambient concentrations of traffic-related NOX and fine particulate matter. Environ Sci Tech. 2007;41(7):2422–8.CrossRefGoogle Scholar
  10. 10.
    Carlsten C, Dybuncio A, Becker A, Chan-Yeung M, Brauer M. Traffic-related air pollution and incident asthma in a high-risk birth cohort. Occup Environ Med. 2011;68(4):291–5.PubMedCrossRefGoogle Scholar
  11. 11.
    Gehring U, Wijga AH, Brauer M, Fischer P, de Jongste JC, Kerkhof M, et al. Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life. Am J Respir Crit Care Med. 2010;181(6):596–603.PubMedCrossRefGoogle Scholar
  12. 12.
    Kramer U, Sugiri D, Ranft U, Krutmann J, von Berg A, Berdel D, et al. Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas. J Dermatol Sci. 2009;56(2):99–105.PubMedCrossRefGoogle Scholar
  13. 13.
    Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Kramer U, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med. 2008;177(12):1331–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Nordling E, Berglind N, Melen E, Emenius G, Hallberg J, Nyberg F, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology. 2008;19(3):401–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Salam MT, Lin PC, Avol EL, Gauderman WJ, Gilliland FD. Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma. Thorax. 2007;62(12):1050–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Kelly FJ. Oxidative stress: its role in air pollution and adverse health effects. Occup Environ Med. 2003;60(8):612–6.PubMedCrossRefGoogle Scholar
  17. 17.
    Melén E, Nyberg F, Lindgren CM, Berglind N, Zucchelli M, Nordling E, et al. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect. 2008;116(8):1077–84.PubMedCrossRefGoogle Scholar
  18. 18.
    Schroer KT, Biagini Myers JM, Ryan PH, LeMasters GK, Bernstein DI, Villareal M, et al. Associations between multiple environmental exposures and glutathione S-transferase P1 on persistent wheezing in a birth cohort. J Pediatr. 2009;154(3):401–8, 8 e1.Google Scholar
  19. 19.
    Carlsten C, Dybuncio A, Becker A, Chan-Yeung M, Brauer M. GSTP1 polymorphism modifies risk for incident asthma associated with nitrogen dioxide in a high-risk birth cohort. Occup Environ Med. 2011;68(4):308.PubMedCrossRefGoogle Scholar
  20. 20.
    London SJ. Gene-air pollution interactions in asthma. Proc Am Thorac Soc. 2007;4(3):217–20.PubMedCrossRefGoogle Scholar
  21. 21.
    Kozyrskyj AL, HayGlass KT, Sandford AJ, Pare PD, Chan-Yeung M, Becker AB. A novel study design to investigate the early-life origins of asthma in children (SAGE study). Allergy. 2009;64(8):1185–93.PubMedCrossRefGoogle Scholar
  22. 22.
    Wickman M, Kull I, Pershagen G, Nordvall SL. The BAMSE project: presentation of a prospective longitudinal birth cohort study. Pediatr Allergy Immunol. 2002;13(Suppl 15):11–3.PubMedCrossRefGoogle Scholar
  23. 23.
    Gehring U, Cyrys J, Sedlmeir G, Brunekreef B, Bellander T, Fischer P, et al. Traffic-related air pollution and respiratory health during the first 2 yrs of life. Eur Respir J. 2002;19(4):690–8.PubMedCrossRefGoogle Scholar
  24. 24.
    Koopman LP, van Strien RT, Kerkhof M, Wijga A, Smit HA, de Jongste JC, et al. Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med. 2002;166(3):307–13.PubMedCrossRefGoogle Scholar
  25. 25.
    Lewné M, Cyrys J, Meliefste K, Brauer M, Fischer P, Gehring U, et al. Spatial variation of outdoor nitrogen dioxide in Munich (Germany), the Netherlands and Stockholm County (Sweden). Sci Total Environ. 2004;332:217–30.PubMedCrossRefGoogle Scholar
  26. 26.
    Hochadel M, Heinrich J, Gehring U, Morgenstern V, Kuhlbusch T, Link E, et al. Predicting long-term average concentrations of traffic-related air pollutants using GIS-based information. Atmos Environ. 2006;40:542–53.CrossRefGoogle Scholar
  27. 27.
    Bellander T, Berglind N, Gustavsson P, Jonson T, Nyberg F, Pershagen G, et al. Using geographic information systems to assess individual historical exposure to air pollution from traffic and house heating in Stockholm. Environ Health Perspect. 2001;109(6):633–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Beelen R, Hoek G, Pebesma E, Vienneau D, de Hoogh K, Briggs DJ. Mapping of background air pollution at a fine spatial scale across the European Union. Sci Total Environ. 2009;407(6):1852–67.PubMedCrossRefGoogle Scholar
  29. 29.
    Bauer M, Herbarth O, Aust G, Hengstler JG, Dotzauer A, Graebsch C, et al. Expression patterns and novel splicing variants of glutathione-S-transferase isoenzymes of human lung and hepatocyte cell lines. Cell Tissue Res. 2006;324(3):423–32.PubMedCrossRefGoogle Scholar
  30. 30.
    Ren C, Vokonas PS, Suh H, Fang S, Christiani DC, Schwartz J. Effect modification of air pollution on Urinary 8-Hydroxy-2’-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions. Environ Health. 2010;9:78.PubMedCrossRefGoogle Scholar
  31. 31.
    Yang IA, Fong KM, Zimmerman PV, Holgate ST, Holloway JW. Genetic susceptibility to the respiratory effects of air pollution. Thorax. 2008;63(6):555–63.PubMedGoogle Scholar
  32. 32.
    Brunekreef B. Health effects of air pollution observed in cohort studies in Europe. J Expo Sci Environ Epidemiol. 2007;17(Suppl 2):S61–5.PubMedCrossRefGoogle Scholar
  33. 33.
    Emenius G, Pershagen G, Berglind N, Kwon HJ, Lewne M, Nordvall SL, et al. NO2, as a marker of air pollution, and recurrent wheezing in children: a nested case-control study within the BAMSE birth cohort. Occup Environ Med. 2003;60(11):876–81.PubMedCrossRefGoogle Scholar
  34. 34.
    Eeftens M, Beelen R, Fischer P, Brunekreef B, Meliefste K, Hoek G. Stability of measured and modelled spatial contrasts in NO(2) over time. Occup Environ Med. 2011;68(10):765–70.PubMedCrossRefGoogle Scholar
  35. 35.
    Madsen C, Gehring U, Håberga SE, Nafstad P, Meliefste K, Nystad W, et al. Comparison of land-use regression models for predicting spatial NOx contrasts over a three year period in Oslo, Norway. Atmos Environ. 2011;45(21):3576–83.CrossRefGoogle Scholar
  36. 36.
    Wang R. Assessment of the temporal stability of land use regression models for traffic-related air pollution. Kelowna: University of British Columbia; 2011.Google Scholar
  37. 37.
    Blettner M, Sauerbrei W, Schlehofer B, Scheuchenpflug T, Friedenreich C. Traditional reviews, meta-analyses and pooled analyses in epidemiology. Int J Epidemiol. 1999;28(1):1–9.PubMedCrossRefGoogle Scholar
  38. 38.
    Vrijheid M, Casas M, Bergstrom A, Carmichael A, Cordier S, Eggesbo M, et al. European birth cohorts for environmental health research. Environ Health Perspect. 2012;120(1):29–37.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Elaina A. MacIntyre
    • 1
    • 2
  • Christopher Carlsten
    • 3
  • Meaghan MacNutt
    • 4
  • Elaine Fuertes
    • 1
    • 2
  • Eric Melén
    • 5
    • 6
  • Carla M. T. Tiesler
    • 2
    • 7
  • Ulrike Gehring
    • 8
  • Ursula Krämer
    • 9
  • Claudia Klümper
    • 9
  • Marjan Kerkhof
    • 10
  • Moira Chan-Yeung
    • 3
  • Anita L. Kozyrskyj
    • 11
  • Dietrich Berdel
    • 12
  • Carl Peter Bauer
    • 13
  • Olf Herbarth
    • 14
  • Mario Bauer
    • 15
  • Beate Schaaf
    • 16
  • Sibylle Koletzko
    • 17
  • Goran Pershagen
    • 5
  • Bert Brunekreef
    • 8
    • 18
  • Joachim Heinrich
    • 2
  • Michael Brauer
    • 1
    • 3
  1. 1.School of Population and Public HealthUniversity of British ColumbiaVancouverCanada
  2. 2.Institute of Epidemiology I, Helmholtz Zentrum MünchenGerman Research Centre for Environmental HealthNeuherbergGermany
  3. 3.Department of MedicineUniversity of British ColumbiaVancouverCanada
  4. 4.Respiratory Medicine DivisionUniversity of British ColumbiaVancouverCanada
  5. 5.Institute of Environmental MedicineKarolinska InstitutetStockholmSweden
  6. 6.Sachs’ Children’s HospitalStockholmSweden
  7. 7.Division of Metabolic Diseases and Nutritional Medicine, Dr. von Hauner Children’s HospitalLudwig-Maximilians-University of MunichMunichGermany
  8. 8.Institute for Risk Assessment SciencesUtrecht UniversityUtrechtThe Netherlands
  9. 9.Leibniz Research Institute for Environmental MedicineUniversity of DüsseldorfDüsseldorfGermany
  10. 10.University Medical Center Groningen, GRIAC Research InstituteUniversity of GroningenGroningenThe Netherlands
  11. 11.Department of Pediatrics, Faculty of Medicine and Dentistry, Women and Children’s Research Institute, School of Public HealthUniversity of AlbertaAlbertaCanada
  12. 12.Department of PediatricsMarien-Hospital WeselWeselGermany
  13. 13.Department of PediatricsTechnical University of MunichMunichGermany
  14. 14.Faculty of Medicine, Environmental Medicine and HygieneUniversity of LeipzigLeipzigGermany
  15. 15.Department for Environmental ImmunologyHelmholtz Centre for Environmental Research—UFZLeipzigGermany
  16. 16.Medical Practice for PediatricsBad HonnefGermany
  17. 17.Division of Paediatric Gastroenterology and Hepatology, Dr. von Hauner Children’s HospitalLudwig-Maximilians-University of MunichMunichGermany
  18. 18.Julius Center for Health Sciences and Primary CareUniversity Medical Center UtrechtUtrechtThe Netherlands

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