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European Journal of Epidemiology

, Volume 27, Issue 11, pp 885–886 | Cite as

Publication biases in probiotics

  • Matthieu Million
  • Didier RaoultEmail author
Letter to the Editor

Probiotics are used differently in the food industry and in the medical field. In both cases the probiotics are used, as their name suggests, for beneficial effects. Ironically most of the studies have neglected the use made in the food industry of farm animals to study their role in humans. Indeed, the same chapter of a book, evaluating the use of probiotics in animals and men, mentioned that the same species, Lactobacillus reuteri, is used in piglets to increase weight, and in children to reduce the episodes of intestinal infections. The putative role of L. reuteri in this report as a “growth promoter” for children, as reported for piglets, was not suggested. Indeed later we found a link between weight increase and L. reuteri in humans [1]. In humans the activities of probiotics are mostly reported for prevention of intestinal disorders and diarrhea but also different chronic diseases (http://www.ahrq.gov/clinic/tp/probiotictp.htm).

Probiotics are a very important economic issue, and...

Keywords

Pancreatitis Lactobacillus Publication Bias Farm Animal Growth Promoter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Million M, Maraninchi M, Henry M, Armougom F, Richet H, Carrieri P, et al. Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii. Int J Obes (Lond). 2012;36(6):817–25.CrossRefGoogle Scholar
  2. 2.
    Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.PubMedCrossRefGoogle Scholar
  3. 3.
    Million M, Angelakis E, Paul M, Armougom F, Leibovici L, Raoult D. Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microb Pathog. 2012;53(2):100–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Videlock EJ, Cremonini F. Meta-analysis: probiotics in antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2012;35(12):1355–69.PubMedCrossRefGoogle Scholar
  5. 5.
    Ritchie ML, Romanuk TN. A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One. 2012;7(4):e34938.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes,UMR CNRS 7278, IRD 198, INSERM 1095, Faculté de MédecineAix Marseille UniversitéMarseilleFrance

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