European Journal of Epidemiology

, Volume 27, Issue 9, pp 739–756 | Cite as

The Generation R Study: design and cohort update 2012

  • Vincent W. V. JaddoeEmail author
  • Cornelia M. van Duijn
  • Oscar H. Franco
  • Albert J. van der Heijden
  • Marinus H. van IIzendoorn
  • Johan C. de Jongste
  • Aad van der Lugt
  • Johan P. Mackenbach
  • Henriëtte A. Moll
  • Hein Raat
  • Fernando Rivadeneira
  • Eric A. P. Steegers
  • Henning Tiemeier
  • Andre G. Uitterlinden
  • Frank C. Verhulst
  • Albert Hofman


The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in childhood; and (6) health and healthcare for children and their parents. Main exposures of interest include environmental, endocrine, genetic and epigenetic, lifestyle related, nutritional and socio-demographic determinants. In total, n = 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61 %, and general follow-up rates until the age of 6 years exceed 80 %. Data collection in mothers, fathers and children include questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome and epigenome wide association screen is available in the participating children. From the age of 5 years, regular detailed hands-on assessments are performed in a dedicated research center including advanced imaging facilities such as Magnetic Resonance Imaging. Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.


Cohort Pregnancy Child Fetal 



The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. We gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives and pharmacies in Rotterdam. We thank Marjolein Kooijman, Claudia Kruithof, Natalia Loekabino, Patricia Maeijer, Ronald van den Nieuwenhof, and Karien Toebes for their study coordination. The general design of Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, the Netherlands Organization for Health Research and Development (ZonMw), the Netherlands Organisation for Scientific Research (NWO), the Ministry of Health, Welfare and Sport. Vincent Jaddoe received an additional grant from the Netherlands Organization for Health Research and Development (ZonMw 907.00303, ZonMw 916.10159).


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Vincent W. V. Jaddoe
    • 1
    • 2
    • 3
    Email author
  • Cornelia M. van Duijn
    • 2
  • Oscar H. Franco
    • 2
  • Albert J. van der Heijden
    • 3
  • Marinus H. van IIzendoorn
    • 4
  • Johan C. de Jongste
    • 3
  • Aad van der Lugt
    • 5
  • Johan P. Mackenbach
    • 6
  • Henriëtte A. Moll
    • 3
  • Hein Raat
    • 6
  • Fernando Rivadeneira
    • 7
  • Eric A. P. Steegers
    • 8
  • Henning Tiemeier
    • 2
    • 9
  • Andre G. Uitterlinden
    • 2
    • 7
  • Frank C. Verhulst
    • 9
  • Albert Hofman
    • 2
  1. 1.The Generation R Study Group (AE006)Erasmus Medical CenterRotterdamThe Netherlands
  2. 2.Department of EpidemiologyErasmus Medical CenterRotterdamThe Netherlands
  3. 3.Department of PediatricsSophia Children’s Hospital, Erasmus Medical CenterRotterdamThe Netherlands
  4. 4.School for Pedagogical and Educational SciencesErasmus UniversityRotterdamThe Netherlands
  5. 5.Department of RadiologyErasmus Medical CenterRotterdamThe Netherlands
  6. 6.Department of Public HealthErasmus Medical CenterRotterdamThe Netherlands
  7. 7.Department of Internal MedicineErasmus Medical CenterRotterdamThe Netherlands
  8. 8.Department of Obstetrics and GynaecologyErasmus Medical CenterRotterdamThe Netherlands
  9. 9.Department of Child and Adolescent PsychiatrySophia Children’s Hospital, Erasmus Medical CenterRotterdamThe Netherlands

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