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European Journal of Epidemiology

, Volume 27, Issue 4, pp 247–253 | Cite as

Heritability of body mass index in pre-adolescence, young adulthood and late adulthood

  • Cassandra Nan
  • Boliang Guo
  • Claire Warner
  • Tom Fowler
  • Timothy Barrett
  • Dorret Boomsma
  • Tracy Nelson
  • Keith Whitfield
  • Gaston Beunen
  • Martine Thomis
  • Hermine Hendrik Maes
  • Catherine Derom
  • Juan Ordoñana
  • Jonathan Deeks
  • Maurice Zeegers
REVIEW

Abstract

Increased body mass index (BMI) is a worldwide health issue. Individual differences in the susceptibility to increased BMI could be related to genes or environment. We performed a systematic review of genetic studies on BMI in pre-adolescence, young adulthood and late adulthood. We searched PubMed and EMBASE with heritability, body mass index, BMI, weight, height, anthropometry and twins as search terms. Studies reporting intra-pair correlations of healthy twin pairs that were raised together were included. This resulted in the inclusion of 8,179 monozygotic (MZ) and 9,977 dizygotic (DZ) twin pairs from twelve published studies in addition to individual participant data for 629 MZ and 594 DZ pairs from four twin registries. Structural equation modelling with intra-pair twin correlations showed that the heritability of BMI remained high over all age categories ranging from 61 % (95 % CI 54–64 %) to 80 % (95 % CI 76–81 %) for male and female subjects combined, while unique environmental influences increased from 14 % (95 % CI 13–15 %) to 40 % (95 % CI 37–43 %) with increasing age. Heritability of BMI remains consistently high over different age categories. Environmental changes over time do not seem to have as big a relative impact on an individual’s weight as previously reported, suggesting a mainly genetic influence on variation in BMI over the years.

Keywords

Twins Heritability BMI Body mass index Anthropometry Life span 

Abbreviations

A

Additive genetic influences

BMI

Body mass index

C

Common environmental influences

CAATSA

Carolina African American Twin Study of Aging

DZ

Dizygotic

E

Unique environmental influences

EFPTS

East Flanders Prospective Twin Study

IPD

Individual participant data

LLTS

Leuven Longitudinal Twin Study

MTR

Murcia Twin Register

MZ

Monozygotic

NTR

Netherlands Twin Registry

TEDS

Twins Early Development Study

WHO

World Health Organisation

Notes

Acknowledgments

The authors would like to thank Raymond Timmins of the Department of Public Health at the University of Birmingham (UK) for gathering a large part of the papers. This research was funded by the Birmingham Children’s Hospital Research Foundation (BCHRF102f). The MTR is supported by the Seneca Foundation (08633/PHCS/08) and MICINN (PSI11560-2009). LLTS is supported by the Research Fund Katholieke Universiteit Leuven (OT/86/80), National Bank of Belgium, Fund for Medical Research Belgium (3.0038.82, 3.0008.90, 3.0098.91), and North Atlantic Treaty Organisation (860823). This study was previously published in abstract form in Twin Research and Human Genetics (2010): 13(3), p279.

References

  1. 1.
    WHO (2011) March 2011 [cited 2012 January 24]. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/.
  2. 2.
    WHO (2005) The World Health Organization warns of the rising threat of heart disease and stroke as overweight and obesity rapidly increase, in WHO news release: Geneva.Google Scholar
  3. 3.
    Dietz WH, Gortmaker SL. Do we fatten our children at the television set? Obesity and television viewing in children and adolescents. Pediatrics. 1985;75:807–12.PubMedGoogle Scholar
  4. 4.
    Cohen D. Obesity and the built environment: changes in environmental cues cause energy imbalances. Int J Obes. 2008;32:S137–42.CrossRefGoogle Scholar
  5. 5.
    Hu F, Li T, Colditz G. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. J Am Med Assoc. 2003;289(14):1785–91.CrossRefGoogle Scholar
  6. 6.
    Haworth C, et al. Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity. 2008;16:2663–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Lajunen H, et al. Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins. Int J Obes. 2009;33:559–67.CrossRefGoogle Scholar
  8. 8.
    Carmichael C, McGue M. A cross-sectional examination of height, weight, and body mass index in adult twins. J Gerontol Biol Sci. 1995;50A(4):B237–44.CrossRefGoogle Scholar
  9. 9.
    Koeppen-Schomerus G, Wardle J, Plomin R. A genetic analysis of weight and overweight in 4-year-old twin pairs. Int J Obes. 2001;25:838–44.CrossRefGoogle Scholar
  10. 10.
    Schousboe K, et al. Sex differences in heritability of BMI: a comparative study of results from twin studies in eight countries. Twin Res. 2003;6(5):409–21.PubMedGoogle Scholar
  11. 11.
    Zillikens M, et al. Sex-specific genetic effects influence variation in body composition. Diabetologia. 2008;51:2233–41.PubMedCrossRefGoogle Scholar
  12. 12.
    Wisniewski A, Chernausek S. Gender in childhood obesity: family environment, hormones, and genes. Gend Med. 2009;6:76–85.PubMedCrossRefGoogle Scholar
  13. 13.
    Boomsma D, et al. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet. 2006;9(6):849–57.PubMedCrossRefGoogle Scholar
  14. 14.
    Whitfield K, et al. Does intact pair status matter in the study of African American twins? The Carolina African American Twin Study of Aging. Exp Aging Res. 2003;29(4):407–23.PubMedCrossRefGoogle Scholar
  15. 15.
    Ordoñana J, et al. An initiative in Spain for the study of women’s health: the Murcia Twin Registry. Twin Res Hum Genet. 2006;9(6):865–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Beunen G, et al. Univariate and multivariate genetic analysis of subcutaneous fatness and fat distribution in early adolescence. Behav Genet. 1998;28(4):179–288.CrossRefGoogle Scholar
  17. 17.
    Derom C, et al. The east flanders prospective twin survey (EFPTS). Twin Res Hum Genet. 2006;9(6):733–8.PubMedCrossRefGoogle Scholar
  18. 18.
    WHO (2010) International Classification of Diseases (ICD). 10th ed.Google Scholar
  19. 19.
    Haworth C, et al. Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity. 2008;16(12):2663–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Haworth C, et al. Childhood obesity: genetic and environmental overlap with normal-range BMI. Obesity. 2008;16(7):1585–90.PubMedCrossRefGoogle Scholar
  21. 21.
    Wardle J, et al. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr. 2008;87:398–404.PubMedGoogle Scholar
  22. 22.
    Neale M (1999) Mx: statistical modeling 5th ed: Department of Psychiatry, Box 126 MCV, Richmond, VA 23298.Google Scholar
  23. 23.
    Neale M, Cardon L. Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publishers; 1992.Google Scholar
  24. 24.
    Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60(12):1187–92.PubMedCrossRefGoogle Scholar
  25. 25.
    Sullivan PF, Neale MC, Kendler KS. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry. 2000;157(10):1552–62.PubMedCrossRefGoogle Scholar
  26. 26.
    Harris J, Tambs K, Magnus P. Sex-specific effects for body mass index in the new Norwegian twin panel. Genet Epidemiol. 1995;12:251–65.PubMedCrossRefGoogle Scholar
  27. 27.
    Korkeila M, et al. Effects of gender and age on the heritability of body mass index. Int J Obes. 1991;15:647–54.PubMedGoogle Scholar
  28. 28.
    Silventoinen K, et al. Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men. Genet Epidemiol. 2008;32(4):341–9.PubMedCrossRefGoogle Scholar
  29. 29.
    Nelson T, et al. Genetic and environmental influences on body fat distribution, fasting insulin levels and CVD: are the influences shared? Twin Res Hum Genet. 2000;3(1):43–50.Google Scholar
  30. 30.
    Cardon L, et al. Genetic and environmental correlations between obesity and body fat distribution in adult male twins. Hum Biol. 1994;66(3):465–79.PubMedGoogle Scholar
  31. 31.
    Faith M, et al. Evidence for independent genetic influences of fat mass and body mass index in a pediatric twin sample. Pediatrics. 1999;104:61–7.PubMedCrossRefGoogle Scholar
  32. 32.
    Stunkard A, Foch T, Hrubec Z. A twin study of human obesity. J Am Med Assoc. 1986;256(1):51–4.CrossRefGoogle Scholar
  33. 33.
    Wade T, et al. The influence of genetic and environmental factors in estimations of current body size, desired body size, and body dissatisfaction. Twin Res Hum Genet. 2001;4(4):260–5.Google Scholar
  34. 34.
    Böttcher Y, et al. Obesity genes: implication in childhood obesity. Occas Rev. 2012;22(1):31–6.Google Scholar
  35. 35.
    Berulava T, Horsthemke B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur J Hum Genet. 2010;18(9):1054–6.PubMedCrossRefGoogle Scholar
  36. 36.
    Hofker M, Wijmenga C. A supersized list of obesity genes. Nat Genet. 2009;41(2):139–40.PubMedCrossRefGoogle Scholar
  37. 37.
    Haworth CM, et al. Increasing heritability of BMI and stronger associations with the FTO gene over childhood. Obesity (Silver Spring). 2008;16(12):2663–8.CrossRefGoogle Scholar
  38. 38.
    Pietiläinen K, et al. Genetic and environmental influences on the tracking of body size from birth to early adulthood. Obes Res. 2002;10(9):875–84.PubMedCrossRefGoogle Scholar
  39. 39.
    Ortega-Alonso A, et al. Genetic influences on change in BMI from middle to old age: a 29-year follow-up of twin sisters. Behav Genet. 2009;39:154–64.PubMedCrossRefGoogle Scholar
  40. 40.
    Nelson M, et al. Body mass index gain, fast food, and physical activity: effects of shared environments over time. Obesity. 2006;14(4):701–9.PubMedCrossRefGoogle Scholar
  41. 41.
    Silventoinen K et al. The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies. Int J Obes. 2010;34:29–40.Google Scholar
  42. 42.
    Maes H, Neale M, Eaves L. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet. 1997;27(4):325–51.PubMedCrossRefGoogle Scholar
  43. 43.
    Faith M, et al. Parental feeding attitudes and styles and child body mass index: prospective analysis of a gene-environment interaction. Pediatrics. 2004;114:e429–36.PubMedCrossRefGoogle Scholar
  44. 44.
    Martínez J, et al. Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu β2-adrenoceptor polymorphism. J Nutr. 2003;133:2549–54.PubMedGoogle Scholar
  45. 45.
    Silventoinen K, et al. Genetics of pubertal timing and its associations with relative weight in childhood and adult height: the Swedish Young Male Twins Study. Pediatrics. 2008;121(4):e885–91.PubMedCrossRefGoogle Scholar
  46. 46.
    Beunen G, et al. Genetic variance of adolescent growth in stature. Ann Hum Biol. 2000;27(2):173–86.PubMedCrossRefGoogle Scholar
  47. 47.
    Rogol A, Clark P, Roemnich J. Growth and pubertal development in children and adolescents: effects of diet and physical activity. Am J Clin Nutr. 2000;72(supplement):521S–8S.PubMedGoogle Scholar
  48. 48.
    Hur Y-M. Sex difference in heritability of BMI in South Korean adolescent twins. Obesity. 2007;15:2908–11.PubMedCrossRefGoogle Scholar
  49. 49.
    Harrington D, Elliott S. Weighing the importance of neighbourhood: a multilevel exploration of the determinants of overweight and obesity. Soc Sci Med. 2009;68:593–600.PubMedCrossRefGoogle Scholar
  50. 50.
    Kremers S, et al. Environmental influences on energy balance-related behaviors: a dual-process view. Int J Behav Nutr Phys Act. 2006;3:9.PubMedCrossRefGoogle Scholar
  51. 51.
    Pietiläinen K, et al. Physical inactivity and obesity: a vicious circle. Obesity. 2008;16(2):409–14.PubMedCrossRefGoogle Scholar
  52. 52.
    Mustelin L, et al. Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins. Int J Obes. 2009;33:29–36.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Cassandra Nan
    • 1
  • Boliang Guo
    • 2
  • Claire Warner
    • 1
    • 3
  • Tom Fowler
    • 1
    • 4
  • Timothy Barrett
    • 5
  • Dorret Boomsma
    • 6
  • Tracy Nelson
    • 7
  • Keith Whitfield
    • 8
  • Gaston Beunen
    • 9
  • Martine Thomis
    • 9
  • Hermine Hendrik Maes
    • 9
    • 10
  • Catherine Derom
    • 11
  • Juan Ordoñana
    • 12
  • Jonathan Deeks
    • 2
  • Maurice Zeegers
    • 1
    • 13
  1. 1.Unit of Urologic and Genetic Epidemiology, Department of Public Health, Epidemiology and BiostatisticsUniversity of BirminghamBirminghamUK
  2. 2.Biostatistics Group, Department of Public Health, Epidemiology and BiostatisticsUniversity of BirminghamBirminghamUK
  3. 3.Mental Health Commissioning and Service RedesignNHSCambridgeshireUK
  4. 4.Department of Public HealthHeart of Birmingham Teaching PCTBirminghamUK
  5. 5.School of Clinical and Experimental MedicineUniversity of BirminghamBirminghamUK
  6. 6.Department of Biological PsychologyVU UniversityAmsterdamThe Netherlands
  7. 7.Health and Exercise Science and Colorado School of Public HealthColorado State UniversityFort CollinsUnited States of America
  8. 8.Department of Psychology and NeuroscienceDuke UniversityDurhamUnited States of America
  9. 9.Department of Kinesiology, Faculty of Kinesiology and Rehabilitation SciencesKatholieke Universiteit LeuvenLeuvenBelgium
  10. 10.Department of Human and Molecular Genetics, Virginia Institute of Psychiatric and Behavioral GeneticsVirginia Commonwealth UniversityRichmondUnited States of America
  11. 11.Department of Human GeneticsUniversity Hospital Gasthuisberg, Katholieke Universiteit LeuvenLeuvenBelgium
  12. 12.Area of PsychobiologyUniversity of MurciaMurciaSpain
  13. 13.Department of Complex Genetics, Cluster of Genetics and Cell Biology, Nutrition and Toxicology Research Institute MaastrichtMaastricht UniversityMaastrichtThe Netherlands

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