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European Journal of Epidemiology

, Volume 27, Issue 4, pp 315–318 | Cite as

Diethylstilbestrol exposure: evaluation of the doses received in France

  • Michel TournaireEmail author
  • Emmanuel Devouche
  • Sylvie Epelboin
  • Anne Cabau
Letters to the Editor

In an analysis of two prospective studies on the relationship between DES exposure in utero and breast cancer, Adami et al. [1] oppose a dose dependent excess risk after the age of 40 years [2] and the absence of evidence of such an excess risk [3]. Indeed, the American study [2] suggested an excess risk of breast cancer for women exposed in utero aged 40 years or more. The Incidence Rate Ratio (IRR) was 1.91 (95 % CI 1.09–3.33) relative to unexposed cohorts. Nevertheless, IRR was significant for high dose exposure (IRR = 2.16, 95 % CI, 1.18–3.96) but not for low-dose exposure (IRR = 1.63, 95 % CI, 0.87–3.08) relative to unexposed cohort. The Dutch study [3] by contrast revealed no increase of breast cancer for DES-exposed daughters.

One hypothesis that may explain these discordant results, besides possible differences in age of the cohorts and methods, concerns the differences in doses of DES given in the United States and in the Netherlands. This could stimulate a renewed interest in...

Keywords

Breast Cancer Breast Cancer Risk Incidence Rate Ratio Diethylstilbestrol French Cohort 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Michel Tournaire
    • 1
    Email author
  • Emmanuel Devouche
    • 2
  • Sylvie Epelboin
    • 1
  • Anne Cabau
    • 1
  1. 1.Assistance Publique-Hôpitaux de ParisChatenay-MalabryFrance
  2. 2.Université Paris DescartesParisFrance

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