Wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events: a meta-analysis
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In previous studies evaluating whether different alcoholic beverages would protect against cardiovascular disease, a J-shaped relationship for increasing wine consumption and vascular risk was found; however a similar association for beer or spirits could not be established. An updated meta-analysis on the relationship between wine, beer or spirit consumption and vascular events was performed. Articles were retrieved through March 2011 by PubMed and EMBASE search and a weighed least-squares regression analysis pooled data derived from studies that gave quantitative estimation of the vascular risk associated with the alcoholic beverages. From 16 studies, evidence confirms a J-shaped relationship between wine intake and vascular risk. A significant maximal protection—average 31% (95% confidence interval (CI): 19–42%) was observed at 21 g/day of alcohol. Similarly, from 13 studies a J-shaped relationship was apparent for beer (maximal protection: 42% (95% CI: 19–58%) at 43 g/day of alcohol). From 12 studies reporting separate data on wine or beer consumption, two closely overlapping dose–response curves were obtained (maximal protection of 33% at 25 g/day of alcohol). This meta-analysis confirms the J-shaped association between wine consumption and vascular risk and provides, for the first time, evidence for a similar relationship between beer and vascular risk. In the meta-analysis of 10 studies on spirit consumption and vascular risk, no J-shaped relationship could be found.
KeywordsMeta-analysis Alcohol Cardiovascular disease Mortality
Supported in part by Cervisia Consulenze and Istituto Nazionale per la Comunicazione.
Conflict of interest
This was an investigator-initiated study. The partial sponsor of the study had no role in the selection of articles or conduct of the analyses or drafting of the manuscript. We disclaim any other relationships with industry that might pose a conflict of interest in connection with the submitted article.
- 6.Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, HeJ. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003;289(5):579–88.Google Scholar
- 7.Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ. 2011;342:d671.Google Scholar
- 14.Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA. 2000;283(15):2008–12.Google Scholar
- 16.Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988;319(5):267–73.Google Scholar
- 18.Tavani A, La Vecchia C, Negri A, D’Avanzo B, Franzoni M, Tognoni G. Alcohol intake and risk of myocardial infarction in Italian men. J Epidemiol Biostat. 1996;1(1):31–9.Google Scholar
- 19.Renaud SC, Guéguen R, SiestG, Salamon R. Wine, beer, and mortality in middle-aged men from eastern France. Arch Intern Med. 1999;159(16):1865–70.Google Scholar
- 28.Harriss LR, English DR, Hopper JL, et al. Alcohol consumption and cardiovascular mortality accounting for possible misclassification of intake: 11-year follow-up of the Melbourne Collaborative Cohort Study. Addiction. 2007;102(10):1574–85.Google Scholar
- 29.Schröder H, Masabeu A, Marti MJ, et al. Myocardial infarction and alcohol consumption: a population-based case-control study. Nutr Metab Cardiovasc Dis. 2007;17(8):609–15.Google Scholar
- 32.Streppel MT, Ocké MC, Boshuizen HC, Kok FJ, Kromhout D. Long-term wine consumption is related to cardiovascular mortality and life expectancy independently of moderate alcohol intake: the Zutphen study. J Epidemiol Community Health. 2009;63(7):534–40.Google Scholar
- 35.Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with application to meta-analysis. Am J Epidemiol. 1992;135(11):1301–9.Google Scholar
- 38.Wells G, Shea B, O’Connell D. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa Health Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
- 39.Tramacere I, Scotti L, Jenab M, Bagnardi V, Bellocco R, Rota M, Corrao G, Bravi F, Boffetta P, La Vecchia C. Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation. Int J Cancer. 2010;126(6):1474–86.Google Scholar
- 43.Trevisan M, Schisterman E, Mennotti A, Farchi G, Conti S, Risk Factor and Life Expectancy Research Group. Drinking pattern and mortality: the Italian risk factor and life expectancy pooling project. Ann Epidemiol. 2001;11(5):312–9.Google Scholar
- 49.Estruch R, Sacanella E, Badia E, et al. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis. 2004;175(1):117–23.Google Scholar