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European Journal of Epidemiology

, Volume 24, Issue 10, pp 649–658 | Cite as

The natural course of Helicobacter pylori infection on endoscopic findings in a population during 17 years of follow-up: the Sørreisa gastrointestinal disorder study

  • Anne Mette AsfeldtEmail author
  • Sonja Eriksson Steigen
  • Maja-Lisa Løchen
  • Bjørn Straume
  • Roar Johnsen
  • Bjørn Bernersen
  • Jon Florholmen
  • Eyvind J. Paulssen
INFECTIOUS DISEASES

Abstract

The natural course of Helicobacter pylori (H. pylori) is poorly understood, as most research in the field has been on patient populations. We studied the natural course of H. pylori and its associations to morphological changes of the gastric mucosa, peptic ulcer, and reflux oesophagitis in a prospective cohort study of subjects with and without dyspepsia. A total of 361 adults (201 men/160 women, mean age 41/42 years) in Sørreisa municipality, Norway who in 1987 were subjected to upper endoscopy and assessed for gastrointestinal symptoms and H. pylori status were followed up in 2004. H. pylori was strongly associated with neutrophilic (odds ratio [OR] 23.79; 95% confidence interval [CI] 11.64:48.61) and mononuclear infiltration (OR 9.43; CI 5.12:17.36), moderately with atrophy of the antrum (OR 1.98; CI 1.17:3.34), but not with atrophy of the gastric body or intestinal metaplasia. Elimination of H. pylori was associated with regression of gastric inflammation and atrophy, whereas intestinal metaplasia progressed. H. pylori was positively associated with peptic ulcer (OR 2.69; CI 1.2:6.02) but not significantly negatively associated with oesophagitis (OR 0.62; CI 0.35:1.09). This is the first prospective study including endoscopic findings of subjects without dyspepsia, to show that the impact of H. pylori on gastric atrophy is only modest, and that eliminating H. pylori does not cause regression of intestinal metaplasia. However, inflammation of the gastric mucosa regresses after H. pylori elimination. H. pylori is only a moderate risk factor for peptic ulcer, and other explanatory factors deserve more attention.

Keywords

Cohort studies Gastritis Helicobacter pylori Peptic ulcer disease Risk assessment 

Abbreviations

ASA

Acetylsalicylic acid

CI

Confidence interval

GORD

Gastro-oesophageal reflux disease

H. pylori

Helicobacter pylori

NSAIDs

Non-steroid anti-inflammatory drugs

OR

Odds ratio

PU

Peptic ulcer

Notes

Acknowledgments

The study was jointly funded by EXTRA funds from the Norwegian Foundation for Health and Rehabilitation, National Association for Digestive Diseases, Northern Norway Regional Health Authority and the University of Tromsø. The authors’ work was independent of the founders.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Anne Mette Asfeldt
    • 1
    Email author
  • Sonja Eriksson Steigen
    • 2
    • 3
  • Maja-Lisa Løchen
    • 1
    • 4
  • Bjørn Straume
    • 1
  • Roar Johnsen
    • 1
    • 5
  • Bjørn Bernersen
    • 6
  • Jon Florholmen
    • 7
    • 8
  • Eyvind J. Paulssen
    • 7
    • 8
  1. 1.Department of Community MedicineUniversity of TromsøTromsøNorway
  2. 2.Department of PathologyUniversity Hospital of North NorwayTromsøNorway
  3. 3.Department of Medical BiologyUniversity of TromsøTromsøNorway
  4. 4.Department of CardiologyUniversity Hospital of North NorwayTromsøNorway
  5. 5.Department of Public Health and General PracticeNorwegian University of Science and TechnologyTrondheimNorway
  6. 6.Helgeland HospitalMo i RanaNorway
  7. 7.Department of Clinical MedicineUniversity of TromsøTromsøNorway
  8. 8.Department of GastroenterologyUniversity Hospital of North NorwayTromsøNorway

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