The Generation R Study: design and cohort update until the age of 4 years

  • Vincent W. V. Jaddoe
  • Cornelia M. van Duijn
  • Albert J. van der Heijden
  • Johan P. Mackenbach
  • Henriëtte A. Moll
  • Eric A. P. Steegers
  • Henning Tiemeier
  • Andre G. Uitterlinden
  • Frank C. Verhulst
  • Albert Hofman
Developmental Epidemiology

DOI: 10.1007/s10654-008-9309-4

Cite this article as:
Jaddoe, V.W.V., van Duijn, C.M., van der Heijden, A.J. et al. Eur J Epidemiol (2008) 23: 801. doi:10.1007/s10654-008-9309-4

Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. In addition, more detailed assessments are conducted in a subgroup of 1,232 pregnant women and their children. Data collection in the prenatal phase and postnatal phase until the age of 4 years includes questionnaires, detailed physical and ultrasound examinations, behavioural observations and biological samples. This paper gives an update of the study design and cohort profile until the children’s age of 4 years. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

Keywords

Design Cohort study Child Pregnancy 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Vincent W. V. Jaddoe
    • 1
    • 2
    • 3
  • Cornelia M. van Duijn
    • 2
  • Albert J. van der Heijden
    • 3
  • Johan P. Mackenbach
    • 4
  • Henriëtte A. Moll
    • 3
  • Eric A. P. Steegers
    • 5
  • Henning Tiemeier
    • 2
    • 6
  • Andre G. Uitterlinden
    • 2
    • 7
  • Frank C. Verhulst
    • 6
  • Albert Hofman
    • 2
  1. 1.The Generation R Study Group (AE006)Erasmus Medical CenterRotterdamThe Netherlands
  2. 2.Department of EpidemiologyErasmus Medical CenterRotterdamThe Netherlands
  3. 3.Department of PaediatricsErasmus Medical Center, Sophia Children’s HospitalRotterdamThe Netherlands
  4. 4.Department of Public HealthErasmus Medical CenterRotterdamThe Netherlands
  5. 5.Department of Obstetrics & GynaecologyErasmus Medical CenterRotterdamThe Netherlands
  6. 6.Department of Child & Adolescent PsychiatryErasmus Medical Center, Sophia Children’s HospitalRotterdamThe Netherlands
  7. 7.Department of Internal MedicineErasmus Medical CenterRotterdamThe Netherlands

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