The association of the metabolic syndrome with QTc interval in NHANES III

  • Mohammed F. Faramawi
  • Rachel P. Wildman
  • Jeanette Gustat
  • Janet Rice
  • Mohammed Y. Abdul Kareem

DOI: 10.1007/s10654-008-9252-4

Cite this article as:
Faramawi, M.F., Wildman, R.P., Gustat, J. et al. Eur J Epidemiol (2008) 23: 459. doi:10.1007/s10654-008-9252-4


Purpose To examine the relationship of metabolic syndrome with corrected QT interval duration. Methods In a cross-sectional analysis of NHANES III, a representative sample of the adult US population, 3,495 individuals aged ≥40 years were categorized as having metabolic syndrome and not having metabolic syndrome as defined by ATP III. QT interval was measured from the standard 12-lead electrocardiogram. Results A weighted multi-linear regression analysis adjusted for age, gender, serum calcium, and potassium showed that metabolic syndrome was significantly associated with a corrected QT interval in milliseconds. The adjusted Beta coefficient and its corresponding standard error were (4.48 milliseconds, 0.95 milliseconds, P < 0.01). Conclusion These data indicate that metabolic syndrome is independently associated with a corrected QT interval duration. This study calls for careful ECG monitoring among persons with metabolic syndrome for early detection of a long corrected QT interval in order to prevent severe and often fatal arrhythmias.


Metabolic syndrome Cross-sectional studies Electrocardiography 

Supplementary material

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(DOC 26 kb)
10654_2008_9252_MOESM2_ESM.doc (27 kb)
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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Mohammed F. Faramawi
    • 1
  • Rachel P. Wildman
    • 2
  • Jeanette Gustat
    • 3
  • Janet Rice
    • 4
  • Mohammed Y. Abdul Kareem
    • 5
  1. 1.Department of Preventive medicineMenufiya UniversityMenufiyaEgypt
  2. 2.Department of Epidemiology and Population HealthAlbert Einstein College of MedicineNew YorkUSA
  3. 3.Department of EpidemiologyTulane School of Public Health & Tropical Medicine (SPHTM)New OrleansUSA
  4. 4.Department of BiostatisticsTulane School of Public Health & Tropical Medicine (SPHTM)New OrleansUSA
  5. 5.Department of Internal MedicineMenufiya UniversityMenufiyaEgypt

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