European Journal of Epidemiology

, Volume 23, Issue 3, pp 219–225 | Cite as

Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K

  • Yumi YaegashiEmail author
  • Toshiyuki Onoda
  • Kozo Tanno
  • Toru Kuribayashi
  • Kiyomi Sakata
  • Hajime Orimo


Objective To analyze the association between hip fracture incidence in 12 regional blocks within Japan and dietary intake of four key nutrients: calcium, magnesium, vitamin D, and vitamin K. Design An ecological study. Methods Using data from the 2002 national survey on the incidence of hip fracture and the National Nutritional Survey of Japan, a standardized incidence ratio of hip fracture was calculated, and the association between the standardized incidence ratio and each nutritional intake was assessed for each region using Pearson’s correlation coefficient and partial correlation analysis. Results There were significant correlations between the standardized incidence ratio by region and magnesium, vitamin D, and vitamin K in both men and women, and calcium in women. The strongest inverse correlations were found in vitamin K in both men and women (= −0.844, P = 0.001, and r = −0.834, P = 0.001, respectively). After adjusting for calcium, magnesium, and vitamin D, the partial correlation between the standardized incidence ratio by regional block and vitamin K was strongest in both men and women (partial correlation coefficient, pcc = −0.673, P = 0.04; pcc = −0.575, P = 0.106, respectively). Conclusions The significant correlation between hip fracture incidence and vitamin K intake, and also regional variations in food patterns, suggest that increasing intake of vegetables and legumes might lead to a decrease in hip fracture incidence in the future. Further, this study suggests that a review of the dietary reference value of vitamin K from the perspective of osteoporosis would be useful.


Ecological study Hip fracture Nationwide survey Nutrients Regional difference Vitamin K 



Partial correlation coefficient


Bone mass density



The authors thank Ruth Bonita for comments on an earlier draft of this paper.


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Yumi Yaegashi
    • 1
    Email author
  • Toshiyuki Onoda
    • 1
  • Kozo Tanno
    • 1
  • Toru Kuribayashi
    • 2
  • Kiyomi Sakata
    • 1
  • Hajime Orimo
    • 3
  1. 1.Department of Hygiene and Preventive MedicineSchool of Medicine, Iwate Medical UniversityMorioka, IwateJapan
  2. 2.Department of Health and Physical Education, Faculty of EducationIwate UniversityIwateJapan
  3. 3.Health Science UniversityYamanashiJapan

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