European Journal of Epidemiology

, Volume 23, Issue 1, pp 29–35 | Cite as

Maternal acute respiratory infectious diseases during pregnancy and birth outcomes

  • Ferenc Bánhidy
  • Nándor Ács
  • Erzsébet H. Puhó
  • Andrew E. Czeizel
Perinatal Epidemiology


The objective of the study was to evaluate the possible association between maternal acute respiratory infectious diseases (ARID) during pregnancy and birth outcomes. Newborn infants born to mothers with or without ARID as reference were compared in the population-based large data set of newborns without any defect in the Hungarian Case–Control Surveillance System of Congenital Abnormalities. Main outcome measures were birth weight and gestational age at delivery, in addition the rate of preterm births and low birthweight newborns. Of 38,151 newborns, 3,455 (9.1%) had mothers with ARID during pregnancy which were differentiated according to six manifestations from sinusitis to the pneumonia. Mothers with ARID in pregnancy had a longer (0.3 week) gestational age at delivery (adjusted t = 5.4; p < 0.0001) and a lower rate of preterm births (6.7% vs. 9.4%) [adjusted odds ratio (OR) with 95% confidence interval (CI): 0.72, 0.63–0.83] than mothers without ARID. However, severe ARID (bronchitis–bronchiolitis and particularly pneumonia) associated with a higher rate of preterm births (13.0%, adjusted OR with 95% CI: 1.4, 1.1–1.8), while mild ARID (sinusitis, pharyngitis, tonsillitis, laryngitis–tracheitis) resulted in a lower rate of preterm births (5.5%, adjusted OR with 95% CI: 0.5, 0.4–0.7). In conclusion, there was an obvious correlation between severity of ARID in pregnant women and rate of preterm births.


Acute respiratory infectious diseases Pregnancy Gestational age at delivery Preterm birth 



Acute respiratory infectious diseases


Hungarian Case–Control Surveillance of Congenital Abnormalities


  1. 1.
    Hartert TV, Neuzil KM, Shintani AK, Mitchel EF Jr, Snowden MS, Wood LB, Dittus RS, Griffin MR. Maternal morbidity and perinatal outcomes among pregnant women with respiratory hospitalizations during influenza season. Am J Obstet Gynecol 2003;189:1705–1712.PubMedCrossRefGoogle Scholar
  2. 2.
    Ács N, Bánhidy F, Puhó E, Czeizel AE. Acute respiratory infections during pregnancy and congenital abnormalities: case–control study. Congenit Anom (Kyoto) 2006;46:86–96.CrossRefGoogle Scholar
  3. 3.
    Brejkedahl T, Czeizel AE, Hogner DW. Birth weight of single livebirths and weight specific early neonatal mortality in Hungary and Norway. Paediatr Perinat Epidemiol 1983;3:29–40.Google Scholar
  4. 4.
    Czeizel AE, Rockenbauer M, Siffel CS, Varga E. Description and mission evaluation of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980–1996. Teratology 2001;63:176–185.PubMedCrossRefGoogle Scholar
  5. 5.
    Czeizel AE. The first 25 years of the Hungarian Congenital Abnormality Registry. Teratology 1997;55:299–305.PubMedCrossRefGoogle Scholar
  6. 6.
    Czeizel AE, Petik D, Vargha P. Validation studies of drug exposures in pregnant women. Pharmacoepidemiol Drug Saf 2003;12:409–416.PubMedCrossRefGoogle Scholar
  7. 7.
    Bánhidy F, Ács N, Puhó E, Czeizel AE. Pregnancy complications and delivery outcomes of pregnant women with influenza. J Matern Fetal Neonatal Med 2006;19:135–140.PubMedCrossRefGoogle Scholar
  8. 8.
    Bánhidy F, Ács N, Puhó E, Czeizel AE. Pregnancy complications and delivery outcomes of pregnant women with common cold. Cent Eur J Public Health 2006;14:10–14.PubMedGoogle Scholar
  9. 9.
    Somoskövi Á, Bártfay Z, Tamási L, et al. Population-based case–control study of allergic rhinitis during pregnancy for birth outcomes. Eur J Obstet Gynecol Reprod Biol 2007;131:21–27.PubMedCrossRefGoogle Scholar
  10. 10.
    Ács N, Puhó E, Bánhidy F, Czeizel AE. Association between bronchial asthma in pregnancy and shorter gestational age in a population-based study. J Matern Fetal Neonatal Med 2005;18:107–112.PubMedCrossRefGoogle Scholar
  11. 11.
    Czeizel AE, Petik D, Vargha P. The reliability of retrospective maternal self-reported information concerning smoking and alcohol drinking pregnancy. Cent Eur J Public Health 2004;12:179–183.PubMedGoogle Scholar
  12. 12.
    Czeizel AE, Kodaj I, Lenz WC. Smoking during pregnancy and congenital limb deficiency. BMJ 1994;308:1473–1476.PubMedGoogle Scholar
  13. 13.
    Czeizel AE, Nagy E. Recent etiological study on facial clefting in Hungary. Acta Paediatr Hung 1986;27:145–166.PubMedGoogle Scholar
  14. 14.
    Lower CR. Effect of mothers’ smoking habits on birth weight of their children. BMJ 1959;2:673–676.CrossRefGoogle Scholar
  15. 15.
    Kullander S, Källen B. A prospective study of smoking and pregnancy. Acta Obstet Gynecol Scand 1971;50:83–94.CrossRefGoogle Scholar
  16. 16.
    Roilt IM, Brostoff J, Male D. Immunology. 5th ed. London: Mosby; 1998.Google Scholar
  17. 17.
    Abbas KA, Lichtman AH, Schmitt W. Cellular and molecular immunology. 3rd ed. Philadelphia: Saunders; 1997.Google Scholar
  18. 18.
    Ammon E, Lewis SV, Sibai BM. Ampicillin prophylaxis in preterm premature rupture of the membranes: a prospective randomized study. Am J Obstet Gynecol 1988;159:539–543.Google Scholar
  19. 19.
    Morales WJ, Angel JL, O’Brien WF, Knuppel RA. Use of ampicillin and corticosteroids in premature rupture of membranes: a randomised study. Obstet Gynecol 1989;73:721–726.PubMedGoogle Scholar
  20. 20.
    Kazy Z, Puhó HE, Czeizel AE. The possible preterm birth preventive effect of ampicillin during pregnancy. Arch Gynecol Obstet 2006;274:215–221.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Ferenc Bánhidy
    • 1
  • Nándor Ács
    • 1
  • Erzsébet H. Puhó
    • 2
  • Andrew E. Czeizel
    • 2
  1. 1.Second Department of Obstetrics and Gynecology, School of MedicineSemmelweis UniversityBudapestHungary
  2. 2.Foundation for the Community Control of Hereditary DiseasesBudapestHungary

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