European Journal of Epidemiology

, Volume 22, Issue 7, pp 457–465 | Cite as

Classification of sporadic Creutzfeldt-Jakob disease based on clinical and neuropathological characteristics

  • José Cortiñas Abrahantes
  • Marc Aerts
  • Bart van Everbroeck
  • Claude Saegerman
  • Dirk Berkvens
  • Helena Geys
  • Koen Mintiens
  • Stefan Roels
  • Patrick Cras
Review Paper

Abstract

Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of unknown cause. Patients are usually aged between 50 and 75 and typical clinical features include rapidly progressive dementia associated with myoclonus and a characteristic electroencephalographic pattern. Neuropathological examination reveals cortical spongiform change, hence the term ‘spongiform encephalopathy’. Several statistical techniques were applied to classify patients with sporadic CJD (sCJD), based on clinical and neuropathological investigation. We focus on the classification of neuropathologically confirmed sCJD patients. In order to obtain a classification rule that correctly classifies this type of patients and at the same time controls the overall error rate, we apply several classification techniques, which in general, produce comparable results. The boosting method produces the best results and the variable 14-3-3 protein in cerebrospinal fluid plays the most important role in the prediction of neuropathologically confirmed sCJD.

Keywords

Boosting methods Classification tree Sporadic Creutzfeldt-Jakob disease 

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • José Cortiñas Abrahantes
    • 1
  • Marc Aerts
    • 1
  • Bart van Everbroeck
    • 2
  • Claude Saegerman
    • 3
  • Dirk Berkvens
    • 4
  • Helena Geys
    • 1
    • 5
  • Koen Mintiens
    • 6
  • Stefan Roels
    • 6
  • Patrick Cras
    • 7
  1. 1.Center for StatisticsHasselt UniversityDiepenbeekBelgium
  2. 2.Biobank, Institute Born BungeUniversity of AntwerpAntwerpBelgium
  3. 3.Department of Infectious and Parasitic Diseases, Epidemiology and Risk Analysis, Faculty of Veterinary MedicineUniversity of LiegeLiegeBelgium
  4. 4.Department of Animal HealthInstitute of Tropical MedicineAntwerpBelgium
  5. 5.Johnson & Johnson, PRDBeerseBelgium
  6. 6.Veterinary and Agrochemical Research CentreBrusselsBelgium
  7. 7.Department of NeurologyUniversity Hospital of Antwerp, University of AntwerpAntwerpBelgium

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