European Journal of Epidemiology

, Volume 20, Issue 6, pp 475–488

HLA and disease

  • Yogita Ghodke
  • Kalpana Joshi
  • Arvind Chopra
  • Bhushan Patwardhan
Review

Abstract

Association of HLA and diseases is well known. Several population studies are available suggesting evidence of association of HLAs in more than 40 diseases. HLA found across various populations vary widely. Some of the reasons attributed for such variation are occurrence of social stratification based on geography, language and religion, consequences of founder effect, racial admixture or selection pressure due to environmental factors. Hence certain HLA alleles that are predominantly associated with disease susceptibility or resistance in one population may or may not show any association in other populations for the same disease. Despite of these limitations, HLA associations are widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. This review consolidates the HLA data on some prominent autoimmune and infectious diseases among various ethnic groups and attempts to pinpoint differences in Indian and other population.

Keywords

Autoimmune diseases Disease associations HLA Infectious diseases Population 

Abbreviations

AIDS

Acquired Immunodeficiency Syndrome

AS

Ankylosing Spondylitis

CD

Celiac Disease

GADA

Glutamic Acid Decarboxylase Antibodies

HIV

Human Immunodeficiency Virus

HLA

Human Leukocyte Antigen

IAA

Insulin Autoantibodies

ICA

Islet Cell Antibodies

LD

Linkage Disequilibrium

LMP

Low Molecular weight Proteasome

MHC

Major Histocompatibility Complex

RA

Rheumatoid Arthritis

SLE

Systemic Lupus Erythematosus

TAP

Transporter Associated with antigen Processing

TB

Tuberculosis

TNF

Tumor Necrosis Factor

T1D

Type 1 Diabetes

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Copyright information

© Springer 2005

Authors and Affiliations

  • Yogita Ghodke
    • 1
  • Kalpana Joshi
    • 1
  • Arvind Chopra
    • 2
  • Bhushan Patwardhan
    • 1
  1. 1.Bioprospecting Laboratory, Interdisciplinary School of Health SciencesUniversity of PunePuneIndia
  2. 2.Center for Rheumatic DiseasesPuneIndia

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