European Journal of Epidemiology

, Volume 20, Issue 12, pp 1003–1005 | Cite as

Paternal Age and Epilepsy in the Offspring

  • Mogens VestergaardEmail author
  • Alissa Mork
  • Kreesten M. Madsen
  • Jørn Olsen
Neurological Diseases


Advanced paternal age is associated with a higher rate of de novo mutation in sperm cells and mental disorders in the offspring. In a population based cohort study of 96,654 children, we found that fathers aged 35 years or more were slightly more likely to have a child diagnosed with epilepsy compared to fathers aged 25–29 years. Our data suggest a modest paternal effect on the aetiology of epilepsy.


de novo mutations epidemiology epilepsy paternal age 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Mogens Vestergaard
    • 1
    Email author
  • Alissa Mork
    • 1
    • 2
  • Kreesten M. Madsen
    • 1
  • Jørn Olsen
    • 1
    • 3
  1. 1.The Danish Epidemiology Science Centre, Institute of Public Health, Department of EpidemiologyUniversity of AarhusAarhus CDenmark
  2. 2.Division of Environmental and Occupational HealthUniversity of Minnesota School of Public HealthMinneapolisUSA
  3. 3.Department of EpidemiologyUCLA School of Public HealthLos AngelesUSA

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