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European Journal of Epidemiology

, Volume 19, Issue 10, pp 931–934 | Cite as

The association between HLA DQ genetic polymorphism and type 1 diabetes

  • Adriana Mimbacas
  • Fernando Pérez-bravo
  • Jose Luis Santos
  • Carmen Pisciottano
  • Rosario Grignola
  • Gerardo Javiel
  • Ana Maria Jorge
  • Horacio Cardoso
Diabetes Epidemiology

Abstract

Susceptibility to the type 1 diabetes is genetically controlled and there is an increased risk associated with the presence of some specific alleles of the human leukocyte antigens class II loci (DQA1 and DQB1 genes). The purpose of this study is to evaluate the association between type 1 diabetes and HLA DQ alleles using case-parents trios in the admixed population of Uruguay composed by a mixture of Caucasian, Amerindian and Negroid populations. DQA1 and DQB1 genotyping was performed by polimerase chain reaction followed by oligospecific probes hybridization in 51 case-parents trios. The transmission disequilibrium test was used for detecting differential transmission in the HLA DQ loci. DQB1*0302 was the only allele for which preferential transmission is suggested (probability of transmission=67.56%; exact p-value TDT=0.047 uncorrected for multiple comparisons). DQA1*0301 allele showed a trend for preferential transmission without achieving statistical significance. This result would confirm the hypothesis previously advanced in a case-control study. Therefore, DQB1*0302 allele could be considered as the most important susceptibility allele for developing type 1 diabetes in Uruguay population.

Keywords

HLA IDDM (TDT) Type 1 Diabetes Mellitus Uruguay 

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Adriana Mimbacas
    • 1
    • 2
    • 7
  • Fernando Pérez-bravo
    • 3
  • Jose Luis Santos
    • 3
  • Carmen Pisciottano
    • 4
  • Rosario Grignola
    • 4
  • Gerardo Javiel
    • 5
  • Ana Maria Jorge
    • 6
  • Horacio Cardoso
    • 2
  1. 1.Departamento de Citogenética, Unidad AsociadaInstituto de BiologíaFacultad de CienciasUruguay
  2. 2.Departamento de CitogenéticaInstituto de Investigaciones Biológicas Clemente EstableMontevideoUruguay
  3. 3.Laboratorio de Epidemiología Molecular, Instituto de Nutrición y Tecnología de los AlimentosUniversidad de ChileSantiagoChile
  4. 4.Servicio de Endocrinología PediátricaHospital Pereira RossellMontevideoUruguay
  5. 5.Unidad de Diabetes, C.A.S.M.U.MontevideoUruguay
  6. 6.>Unidad de DiabetesCasa de GaliciaMontevideoUruguay
  7. 7.MontevideoUruguay

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