European Journal of Epidemiology

, Volume 20, Issue 2, pp 183–199 | Cite as

Exposure to ambient air pollution and prenatal and early childhood health effects

  • Marina Lacasaña
  • Ana Esplugues
  • Ferran Ballester
Developmental Epidemiology

Abstract

Over the last years, concern for the possible influence of exposure to air pollutants in children during gestation or the first years of life has grown; exposure levels which may be reached nowadays in our dwellings and in our streets. In the present study evidence over the possible impact of ambient air pollution on the foetus and the infants (i.e.: less than 1 year) published during the last decade, 1994–2003, are revised. Studies on infant mortality and exposure to particles show an outstanding consistence in the magnitude of the effects, despite the different designs used. As a whole, data show that an increase in 10 μg/m3of particle concentration (measured as PM10) is associated with to about 5% increase in post-neonatal mortality for all causes and around 22% for post-neonatal mortality for respiratory diseases. Regarding damage in foetal health, although results are not always consistent, most studies show associations with exposure to air pollution during pregnancy. However, the precise mechanisms of action of air pollutants on adverse reproductive results are still unknown, so is the period of exposure most relevant during pregnancy and the specific pollutant which may represent a higher risk. Follow-up studies evaluating personal exposure to different air pollutants are required, allowing for the adequate evaluation of the impact of each pollutant in different periods of pregnancy, as well as providing hypotheses on their possible mechanisms of action.

Keywords

Ambient air pollution Congenital defects Intrauterine growth retardation Low birth weight Mortality Preterm delivery 

Abbreviations

BW

birth weight

CI

confidence interval

CO

carbon monoxide

IQR

interquartile range

IUGR

intrauterine growth retardation

LBW

low birth weight

NOx

nitrogen oxides

O3

ozone

PAH

polycyclic aromatic hydrocarbons

PCB

polichlorinated biphenyls

PM10

particles ≤ 10 μm diameter

PM2.5

particles ≤ 2.5 μm diameter

TSP

total suspended particles

SGA

small for gestational age

SIDS

sudden infant death syndrome

SMR

standardized mortality ratio

SO2

sulphur dioxide

WP

weeks of pregnancy

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References

  1. Maisonet, M, Bush, TJ, Correa, A, Jaakkola, JJ 2001Relation between ambient air pollution and low birth weight in the northeastern United StatesEnviron Health Perspect109 351356PubMedGoogle Scholar
  2. Rogers, JF, Thompson, SJ, Addy, CL, McKeown, RE, Cowen, DJ, Decouflé, P 2000Association of very low birth weight with exposures to environmental sulfur dioxide and total suspended particlesAm J Epidemiol151602613PubMedGoogle Scholar
  3. Dejmek, J, Solansky, I, Benes, I, Lenicek, J, Sram, RJ 2000The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcomeEnviron Health Perspect10811591164PubMedGoogle Scholar
  4. Bui, QQ, Tran, MB, West, WL 1986A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant ratToxicology42195204PubMedGoogle Scholar
  5. Ribas-Fito, N, Sala, M, Mazón, C,  et al. 2002Association of hexachlorobenzene and other organochlorine compounds with anthropometric measures and thyroid hormone status at birthPediatr Res52163167PubMedGoogle Scholar
  6. Perera, FP, Illman, SM, Kinney, PL,  et al. 2002The challenge of preventing environmentally related disease in young children: community-based research in New York CityEnviron Health Perspect110197204PubMedCrossRefGoogle Scholar
  7. Woodruff, T, Grillo, J, Schoendorf, KC 1997The relationship between selected causes of post-neonatal infant mortality and particulate air pollution in the United StatesEnviron Health Perspect105608612PubMedGoogle Scholar
  8. Pereira, L, Loomis, DP, Conceiao, GMS,  et al. 1998Association between air pollution and intrauterine mortality in Sao Paulo, BrazilEnviron Health Perspect106325329PubMedGoogle Scholar
  9. Ritz, B, Yu, F, Fruin, S, Chapa, G, Shaw, GM, Harris, JA 2002Ambient air pollution and risk of birth defects in Southern CaliforniaAm J Epidemiol1551725PubMedGoogle Scholar
  10. Ritz, B, Yu, F, Chapa, G, Fruin, S 2000Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993Epidemiology11502511CrossRefPubMedGoogle Scholar
  11. Maroziene L, Grazuleviciene R. Maternal exposure to low-level air pollution and pregnancy outcomes: a population-based study. Environ Health 2002; 1: 6Google Scholar
  12. Perera, FP, Rauh, V, Tsai, WY,  et al. 2003Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic populationEnviron Health Perspect111201206PubMedCrossRefGoogle Scholar
  13. Bobak, M, Leon, DA 1992Air pollution and infant mortality in the Czech Republic, 1986–88Lancet34010101014CrossRefPubMedGoogle Scholar
  14. Der-Simonian, R, Laird, N 1986Meta-analysis in clinical trialsControl Clinical Trials7177188Google Scholar
  15. Witter, FR 1993Perinatal mortality and intrauterine growth retardationCurr Opin Obstet Gynecol55659PubMedGoogle Scholar
  16. Chen, SJ, Vohr, BR, Oh, W 1993Effects of birth order, gender, and intrauterine growth retardation on the outcome of very low birth weight in twinsJ Pediatr123132136PubMedGoogle Scholar
  17. Luke, B, Williams, C, Minogue, J, Keith, L 1993The changing pattern of infant mortality in the US: the role of prenatal factors and their obstetrical implicationsInt J Gynaecol Obstet40199212PubMedGoogle Scholar
  18. Spinillo, A, Capuzzo, E, Egbe, TO, Fazzi, E, Colonna, L, Nicola, S 1995Pregnancies complicated by idiopathic intrauterine growth retardation. Severity of growth failure, neonatal morbidity and two-year infant neurodevelopmental outcomeJ Reprod Med40209215PubMedGoogle Scholar
  19. Joseph, KS, Kramer, MS 1996Review of the evidence on fetal and early childhood antecedents of adult chronic diseaseEpidemiol Rev18158174PubMedGoogle Scholar
  20. Ha, EH, Hong, YC, Lee, BE, Woo, BH, Schwartz, J, Christiani, DC 2001Is air pollution a risk factor for low birth weight in Seoul?Epidemiology12643648PubMedGoogle Scholar
  21. Arnold, CC, Kramer, MS, Hobbs, CA, McLean, FH, Usher, RH 1991Very low birth weight: a problematic cohort for epidemiologic studies of very small or immature neonatesAm J Epidemiol134604613PubMedGoogle Scholar
  22. Kramer, MS 1987Determinants of low birth weight: methodological assessment and meta-analysisBull World Health Organ65663737PubMedGoogle Scholar
  23. Glinianaia, SV, Rankin, J, Bell, R, Pless-Mulloli, T, Howel, D 2004Particulate air pollution an fetal healthA systematic review of the epidemiologic evidence. Epidemiology153645Google Scholar
  24. Bobak, M 2000Outdoor air pollution, low birth weight, and prematurityEnviron Health Perspect108173176PubMedGoogle Scholar
  25. Bhopal , R, Phillimore , P, Moffatt , S, Foy , C 1994Is living near a coking works harmful to health? A study of industrial air pollutionJ Epidemiol Community Health48247Google Scholar
  26. Landgren, O 1996Environmental pollution and delivery outcome in southern Sweden: a study with central registriesActa Paediatr8513611364PubMedGoogle Scholar
  27. Dejmek, J, Selevan, SG, Benes, I, Solansky, I, Sram, RJ 1999Fetal growth and maternal exposure to particulate matter during pregnancyEnviron Health Perspect107475480PubMedGoogle Scholar
  28. Lamont, RF 2003The role of infection in preterm labour and birthHosp Med64644647PubMedGoogle Scholar
  29. Andrews, WW, Hauth, JC, Goldenberg, RL 2000Infection and preterm birthAm J Perinatol17357365PubMedGoogle Scholar
  30. Xu, X, Ding, H, Wang, X 1995Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort studyArch Environ Health50407415PubMedCrossRefGoogle Scholar
  31. Peters, A, Döring, A, Wichmann, HE, Koenig, W 1997Increased plasma viscosity during an air pollution episode: a link to mortality?The Lancet34915821587Google Scholar
  32. Wang, X, Ding, H, Ryan, L, Xu, X 1997Association between air pollution and low birth weight: a community-based studyEnviron Health Perspect105514520PubMedGoogle Scholar
  33. Bobak, M, Leon, DA 1999Pregnancy outcomes and outdoor air pollution: an ecological study in districts of the Czech Republic 1986–1988Occup Environ Med56539543PubMedGoogle Scholar
  34. Wood, KA, Youle, RJ 1995The role of free radicals and p53 in neuron apoptosis in vivoJ Neurosci1558515857Perera FP, et al. Environ Health Perspect 2003; 111: 201-206PubMedGoogle Scholar
  35. Wilhelm, M, Ritz, B 2003Residential proximity to traffic and adverse birth outcomes in Los Angeles county, California, 1994–1996Environ Health Perspect111207216PubMedCrossRefGoogle Scholar
  36. Tabacova, S, Baird, DD, Balabaeva, L 1998Exposure to oxidized nitrogen: lipid peroxidation and neonatal health riskArch Environ Health53214221PubMedCrossRefGoogle Scholar
  37. Duvekot, JJ, Cheriex, EC, Pieters, FA, Peeters, LL 1995Severely impaired fetal growth is preceded by maternal hemodynamic maladaptation in very early pregnancyActa Obstet Gynecol Scand74693697PubMedGoogle Scholar
  38. Dummer, TJ, Dickinson, HO, Parker, L 2003Adverse pregnancy outcomes around incinerators and crematoriums in Cumbria, north west England, 1956–1993J Epidemiol Community Health57456461PubMedGoogle Scholar
  39. Mathieu-Nolf, M 2002Poisons in the air: a cause of chronic disease in childrenJ Toxicol Clin Toxicol40483491PubMedGoogle Scholar
  40. Bobak, M, Leon, DA 1999The effect of air pollution on infant mortality appears specific for respiratory causes in the post-neonatal periodEpidemiology10666670CrossRefPubMedGoogle Scholar
  41. Dolk, H, Thakrar, B, Walls, P,  et al. 1999Mortality among residents near cokeworks in Great BritainOccup Environ Med563440CrossRefPubMedGoogle Scholar
  42. Loomis, D, Castillejos, M, Gold, DR, McDonnell, W, Borja-Aburto, VH 1999Air pollution and infant mortality in Mexico CityEpidemiology10118123PubMedGoogle Scholar
  43. Janssen, NA, Hoek, G, Brunekreef, B, Harssema, H, Mensink, I, Zuidhof, A 1998Personal sampling of particles in adults: relation among personal, indoor, and outdoor air concentrationsAm J Epidemiol147537547PubMedGoogle Scholar
  44. Zeger, S, Thomas, D, Dominici, F, Samet, JM, Schwartz, J, Dockery, DW, Cohen, AJ 2000Exposure measurement error in time-series studies of air pollution: concepts and consequencesEnviron Health Perspect108419426PubMedGoogle Scholar
  45. Sarnat, JA, Schwartz, J, Catalano, PJ, Suh, HH 2001Gaseous pollutants in particulate matter epidemiology: confounders or surrogates?Environ Health Perspect10910531061PubMedGoogle Scholar
  46. Ha, EH, Lee, JT, Kim, H,  et al. 2003Infant susceptibility of mortality to air pollution in Seoul, South KoreaPediatrics111284290PubMedGoogle Scholar
  47. Stieb, DM, Judek , S, Burnett , RT 2002Meta-analysis of time-series studies of air pollution and mortality: effects of gases and particles and the influence of cause of death, age, and seasonJ Air Waste Manag Assoc52470484PubMedGoogle Scholar
  48. Pope, CA, Burnett, RT, Thun, MJ, Calle, EE, Krewski, D, Ito, K, Thurston, GD 2002Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollutionJAMA28711321141PubMedGoogle Scholar
  49. Peters, JM, Avol, E, Navidi, W,  et al. 1999A study of twelve Southern California communities with differing levels and types of air pollution I. Prevalence of respiratory morbidityAm J Respir Crit Care Med159760767PubMedGoogle Scholar
  50. Gauderman, WJ, Gilliland, GF, Vora, H,  et al. 2002Association between air pollution and lung function growth in southern California children: results from a second cohortAm J Respir Crit Care Med1667684CrossRefPubMedGoogle Scholar
  51. Brauer, M, Hoek, G, Van Vliet, P,  et al. 2002Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in childrenAm J Respir Crit Care Med16610921098PubMedGoogle Scholar
  52. Gavett, SH, Haykal-Coates, N, Copeland, LB, Heinrich, J, Gilmour, MI 2003Metal Composition of ambient PM2.5 influences severity of allergic airways disease in miceEnviron Health Perspect11114711477PubMedCrossRefGoogle Scholar
  53. Ritz, B, Yu, F 1999The effect of ambient carbon monoxide on low birth weight among children born in southern California between 1989 and 1993Environ Health Perspect1071725PubMedGoogle Scholar
  54. Dolk, H, Pattenden, S, Vrijheid, S,  et al. 2000Perinatal and infant mortality and low birth weight among residents near cokeworks in Great BritainArch Environ Health552630PubMedGoogle Scholar
  55. Ha, EH, Lee, JT, Kim, H,  et al. 2003Infant susceptibility of mortality to air pollution in Seoul, South KoreaPediatrics111284290PubMedGoogle Scholar
  56. Bobak, M, Richards, M, Wadsworth, M 2001Air pollution and birth weight in Britain in 1946Epidemiology16358359Google Scholar
  57. Lin , MC, Yu , HS, Tsai , SS,  et al. 2001aAdverse pregnancy outcome in a petrochemical polluted area in TaiwanJ Toxicol Environ Health63565574Google Scholar
  58. Wilhelm, M, Ritz, B 2003Residential proximity to traffic and adverse birth outcomes in Los Angeles county, California, 1994–1996Environ Health Perspect111201216Google Scholar
  59. Yang, CY, Tseng, YT, Chang, CC 2003Effects of air pollution on birth weight among children born between 1995 and 1997 in Kaohsiung, TaiwanJ Toxicol Environ Health66807816Google Scholar
  60. Lin , MC, Chiu , HF, Yu , HS,  et al. 2001bIncreased risk of preterm delivery in areas with air pollution from a petroleum refinery plant in TaiwanJ Toxicol Environ Health64637644Google Scholar
  61. Tsai, SS, Yu, HS, Liu, CC, Yang, CY 2003Increased incidence of preterm delivery in mothers residing in an industrialized area in TaiwanJ Toxicol Environ Health66987994Google Scholar
  62. Woodruff TJ, Parker JD, Kyle AD, Schoendorf KC. Disparities in exposure to air pollution during pregnancy Environ Health Perspect 2003; 111: 942–946. Google Scholar
  63. Yang CY, Chiu HF, Tsai SS, Chang CC, Chuang HY. Increased risk of preterm delivery in areas with cancer mortality problems from petrochemical complexes Environ Res 2002; 89: 195–200.Google Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Marina Lacasaña
    • 1
    • 2
    • 3
  • Ana Esplugues
    • 1
    • 2
  • Ferran Ballester
    • 1
    • 4
  1. 1.Epidemiology and Statistics UnitValencian School of Studies for HealthValenciaSpain
  2. 2.University Hospital La FeValenciaSpain
  3. 3.Center for Environmental Health, Center for Research in Populational HealthNational Institute of Public HealthCuernavacaMexico
  4. 4.Public Health Department, History of Science and GynaecologyMiguel Hernández UniversityAlicanteSpain

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