Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma
Asthma, as one of the most common chronic diseases in children and adults, is a consequence of complex gene–environment interactions. Polycyclic aromatic hydrocarbons (PAHs), as a group of widespread environmental organic pollutants, are involved in the development, triggering and pathologic changes of asthma. Various previous studies reported the critical roles of PAHs in immune changes, oxidative stress and environment–gene interactions of asthma. EPHX1 (the gene of epoxide hydrolase 1, an enzyme mediating human PAH metabolism) had a possible association with asthma by influencing PAH metabolism. This review summarized that (1) the roles of PAHs in asthma—work as risk factors; (2) the possible mechanisms involved in PAH-related asthma—through immunologic and oxidative stress changes; (3) the interactions between PAHs and EPHX1 involved in asthma—enzymatic activity of epoxide hydrolase 1, which affected by EPHX1 genotypes/SNPs/diplotypes, could influence human PAH metabolism and people’s vulnerability to PAH exposure. This review provided a better understanding of the above interactions and underlying mechanisms for asthma which help to raise public’s concern on PAH control and develop strategies for individual asthma primary prevention.
KeywordsPolycyclic aromatic hydrocarbons (PAHs) Asthma Epoxide hydrolase 1 (EPHX1) Airway inflammation Oxidative stress
This study was supported by the National Natural Science Foundation of China (21876065) and the Department of Education of Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases (2016046). We would like to thank Dr. Stanley Lin for his constructive comments and English language editing.
This study was funded by National Natural Science Foundation of China (Grant Number 21876065) and the Department of Education of Guangdong Government Top-tier University Development Scheme for Research and Control of Infectious Diseases (Grant Number 2016046).
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Conflict of interest
All authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
This article does not contain any studies with human participants or animals performed by any of the authors.
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