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Environmental Geochemistry and Health

, Volume 41, Issue 2, pp 681–698 | Cite as

Toxicological risk assessment of protracted ingestion of uranium in groundwater

  • Sarabjot Kaur
  • Rohit MehraEmail author
Original Paper

Abstract

Groundwater samples have been collected from far-reaching locations in Solan and Shimla districts of Himachal Pradesh, India, and studied for uranium concentration using LED fluorimetry. In this region, uranium in groundwater varies from 0.12 to 19.43 μg L−1. Radiological and chemical toxicity is accounted for different uranium isotopes. The average mortality risk for uranium isotopes 234U, 235U, and 238U are 2.6 × 10−12, 3.5 × 10−10, and 5.9 × 10−8, respectively. Similarly, the mean morbidity risk for 234U, 235U and 238U are 4.1 × 10−12, 5.6 × 10−10 and 9.5 × 10−8, respectively. An attempt has also been made to calculate doses for different age-groups. Highest doses, ranging from 0.30 to 48.23 µSv year−1, are imparted to infants of 7–12 months of age which makes them the most vulnerable group of population. Using Hair Compartmental Model for uranium and mean daily uranium intake of 3.406 μg for 60-year exposure period, organ-specific doses due to uranium radioisotopes, retention in prime organs/tissues and excretion rates via urine, feces and hair pathway are estimated. In this manuscript, the transfer coefficients for kidney, liver, skeleton, GI tract, soft tissues, urinary bladder, and blood are analyzed. Hair compartment model and ICRP’s biokinetic model are compared in terms of uranium load in different organs after 60 years of protracted ingestion. The study on biokinetic behavior of uranium is the first of its kind in the area which is dedicated to environmental and social cause.

Keywords

Uranium biokinetics LED fluorimetry Hazard quotient Lifetime average daily dose Age-adjusted dose Organ-specific dose Transfer coefficients 

Notes

Acknowledgements

The authors humbly acknowledge the financial support of Department of Science and Technology under INSPIRE fellowship. A sincere gratitude is extended to the Director, Dr. B. R. Ambedkar National Institute of Technology, Jalandhar for providing state-of-the-art laboratory facilities and the residents of the district for their co-operation during fieldwork.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. AERB. (2004). Drinking water specifications in India. Department of Atomic energy, Government of India.Google Scholar
  2. Aschner, M., & Jiang, G. C. (2009). Toxicity studies on depleted uranium in primary rat cortical neurons and in Caenorhabditis elegans: What have we learned? Journal of Toxicology and Environmental Health, Part B Critical Reviews, 12, 525–539.CrossRefGoogle Scholar
  3. ATSDR. (1999). Toxicological profile for uranium. Washington: US Department of Health and Human Services, Public Health Service.Google Scholar
  4. Bajwa, B. S., Kumar, S., Singh, S., Sahoo, S. K., & Tripathi, R. M. (2017). Uranium and other heavy toxic elements distribution in the drinking water samples of SW-Punjab, India. Journal of Radiation Research and Applied Sciences, 10, 13–19.CrossRefGoogle Scholar
  5. Balbudhe, A. Y., Srivastava, S. K., Vishwaprasad, K., Srivastava, G. K., Tripathi, R. M., & Puranik, V. D. (2012). Assessment of age-dependent uranium intake due to drinking water in Hyderabad, India. Radiation Protection Dosimetry, 148(4), 502–506.CrossRefGoogle Scholar
  6. Berlin, M., & Rudell, B. (1986). Uranium. In L. Friberg, G. F. Nordberg, & V. B. Vouk (Eds.), Handbook on the toxicology of metals (2nd ed., pp. 623–637). Amsterdam: Elsevier.Google Scholar
  7. Byju, S. B., Sunil, A., Reeba, M., Christa, E., Vaidyan, V., Prasad, R., et al. (2012). Uranium in drinking waters from the south coast districts of Kerala, India. Iranian Journal of Radiation Research, 10, 31–36.Google Scholar
  8. Central Ground Water Board. (2013). Ground water Information Booklet, Simla District Himachal Pradesh. Ministry of Water Resources. Government of India.Google Scholar
  9. Chevari, S., & Likhner, D. (1968). Complex formation of natural uranium in blood. Meditsinskaia radiologiia, 13, 53–57.Google Scholar
  10. Choppin, G., Liljenzin, J. O., & Rydberg, J. (2002). Behavior of radionuclides in the environment, Radiochemistry and Nuclear Chemistry (3rd ed., pp. 653–685). London: Butterworth-Heinemann.Google Scholar
  11. Cooper, J. R., Stradling, G. N., Smith, H., et al. (1982). The behavior of uranium-233 oxide and uranyl-233 nitrate in rats. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 41, 421–433.CrossRefGoogle Scholar
  12. Durbin, P. W. (1984). Metabolic models for uranium. In R. H. Moore, (Ed.), Biokinetics and analysis of uranium in man (pp. F1-F65). Report USUR-05, HEHF-47. Richland, WA: U. S. Uranium Registry and Joint Center for Graduate Study. Google Scholar
  13. Fisher, D. R., Kathren, R. L., & Swint, M. J. (1991). Modified biokinetic model for uranium from analysis of acute exposure to UF6. Health Physics, 60(3), 335–342.CrossRefGoogle Scholar
  14. Guseva Canu, I., Jacob, S., Cardis, E., et al. (2011). Uranium carcinogenicity in humans might depend on the physical and chemical nature of uranium and its isotopic composition: results from pilot epidemiological study of French nuclear workers. Cancer Causes and Control, 22, 1563.  https://doi.org/10.1007/s10552-011-9833-5.CrossRefGoogle Scholar
  15. Hursh, J. B., & Spoor, N. L. (1973). Data on man. In H. C. Hodge, et al. (Eds.), Handbook of experimental pharmacology (Vol. 36, pp. 197–240)., Uranium, plutonium, transplutonic elements Berlin: Springer.Google Scholar
  16. ICRP. (1975). Report of the task group on reference man. ICRP No. 23. Oxford: Pergamon Press.Google Scholar
  17. ICRP. (1988). Individual monitoring for intakes of radio nuclides by workers: Design and interpretation. ICRP No. 54. Annals of the ICRP 19(1/3). Oxford: Pergamon Press.Google Scholar
  18. ICRP. (1993). Protection against Radon-222 at home and work. ICRP Publications 65, Ann. ICRP 23(2), Oxford: Pergamon Press, p. 46.Google Scholar
  19. ICRP. (1995). Age-dependent doses to members of the public from intake of radio nuclides. ICRP Publication 69, Part 3; Ann ICRP 25(1), Oxford: Pergamon Press.Google Scholar
  20. ICRP. (2012). Compendium of dose coefficients based on ICRP Publication 60. ICRP Publications 119, Ann. ICRP 41 (Suppl.)Google Scholar
  21. ICRP. (2014). Age-dependent doses to members of the public from intake of radio nuclides: Part 5, compilation of ingestion and inhalation dose coefficients. ICRP Publication 72, Oxford: Pergamon Press.Google Scholar
  22. Institute of Medicine of the National Academies. (2005). Dietary reference intakes for water, potassium, sodium chloride, and sulphate (DRIs). Washington, DC: The National Academies Press.Google Scholar
  23. Jakhu, R., Mehra, R., & Mittal, H. M. (2016). Exposure assessment of natural uranium from drinking water. Environmental Science: Processes and Impacts, 18, 1540.Google Scholar
  24. Jiang, G. C.-T., & Eschner, M. (2015). Depleted uranium. In R. C. Gupta (Ed.), Handbook of toxicology of chemical warfare agents (2nd ed., pp. 447–460). Cambridge: Academic Press Publishers.CrossRefGoogle Scholar
  25. Kansal, S., Mehra, R., & Singh, N. P. (2011). Uranium concentration in ground water samples belonging to some areas of Western Haryana, India using fission track registration technique. Journal of Public Health and Epidemiology, 3(8), 352–357.Google Scholar
  26. Keith, L. S., Faroon, O. M., & Fowler, B. A. (2007). Uranium. In G. F. Nordberg, B. A. Fowler, M. Nordberg, & L. T. Friberg (Eds.), Handbook on the toxicology of metals. Amsterdam: Elsevier.Google Scholar
  27. Kumar, A., Kaur, M., Mehra, R., Sharma, S., Mishra, R., Singh, K. P., et al. (2016). Quantification and assessment of health risk due to ingestion of uranium in groundwater of Jammu district, Jammu & Kashmir, India. Journal of Radioanalytical and Nuclear Chemistry, 10, 793–804.Google Scholar
  28. Kurttio, P., Komulainen, H., Leino, A., Salonen, L., Auvinen, A., & Saha, H. (2005). Bone as a possible target of chemical toxicity of natural uranium in drinking water. Environmental Health Perspectives, 113, 68–72.CrossRefGoogle Scholar
  29. La Touche, Y. D., Willis, D. L., & Dawydiak, O. I. (1987). Absorption and biokinetics of U in rats following an oral administration of uranyl nitrate solution. Health Physics, 53(2), 147–162.CrossRefGoogle Scholar
  30. Leggett, R. W., & Harrison, J. D. (1995). Fractional absorption of ingested uranium inhumans. Health Physics, 68(4), 484–498.CrossRefGoogle Scholar
  31. Leggett, R. W., & Pellmar, T. C. (2003). The biokinetics of uranium migrating from embedded DU fragments. Journal of Environmental Radioactivity, 64(2–3), 205–225.CrossRefGoogle Scholar
  32. Li, W. B., Karpas, Z., Salonen, L., Kurttio, P., Muikku, M., Wahl, W., et al. (2009). A compartmental model of uranium in human hair for protracted ingestion of natural uranium in drinking water. Health Physics.  https://doi.org/10.1097/01.HP.0000345023.46165.1c.Google Scholar
  33. Lipsztein, J. L. (1981). An improved model for Uranium metabolism in the Primate. Ph.D. Thesis, New York University Institute of Environmental Medicine, New York.Google Scholar
  34. Mehra, R., Singh, S., & Singh, K. (2007). Uranium studies in water samples belonging to Malwa region of Punjab, using track etching technique. Radiation Measurements, 42, 441–445.CrossRefGoogle Scholar
  35. Nga, L. T., Paul, A. L., & Thomas, A. B. (2000). Chemical and radiation environmental risk management: Differences, commonalities and challenges. Risk Analysis, 20(2), 163–172.CrossRefGoogle Scholar
  36. Rana, B., Tripathi, R., Sahoo, S., Sethy, N., Sribastav, V., Shukla, A., et al. (2010). Assessment of natural uranium and 226Ra concentrations in groundwater around the uranium mine at Narwapahar, Jharkhand, India and its radiological significance. Journal of Radioanalytical and Nuclear Chemistry, 285, 711–717.CrossRefGoogle Scholar
  37. Rani, A., Singh, S., Duggal, V., & Balaram, V. (2013). Uranium estimation in drinking water samples from some areas of Punjab and Himachal Pradesh, India using ICP-MS. Radiation Protection Dosimetry, 1–6.Google Scholar
  38. Sharma, N., & Singh, J. (2016). Radiological and chemical risk assessment due to high uranium contents observed in the ground waters of Mansa District (Malwa Region) of Punjab State, India: An area of high cancer incidence. Exposure and Health, 8, 513–525.CrossRefGoogle Scholar
  39. Sheppard, S. C., Sheppard, M. I., Gallerand, M., & Sanipelli, B. (2005). Derivation of ecotoxicity thresholds for uranium. Journal of Environmental Radioactivity, 79, 55–83.CrossRefGoogle Scholar
  40. Shin, D. C., Kim, Y. S., Moon, J. Y., Park, H. S., Kim, J. Y., & Park, S. K. (2000). International trends in risk management of groundwater radio nuclides. Journal of Environmental Toxicology, 17(4), 273–284.Google Scholar
  41. Singh, N. P., Lewis, L. L., & Wrenn, M. E. (1986). Uranium in human tissues of Colorado, Pennsylvania and Utah, USA populations. Health Physics, 50(suppl. 1), S82.Google Scholar
  42. Smedley, P. L., Smith, B., Abesser, C., & Lapworth, D. (2006). Uranium occurrence and behaviour in British groundwater. British Geological Survey Groundwater Systems & Water Quality Programme Commissioned Report CR/06/050. British Geological Survey, Keyworth: Nottigham.Google Scholar
  43. Stevens, W., Bruenger, F. W., Atherton, D. R., et al. (1980). The distribution and retention of hexavalent 233U in the beagle. Radiation Research, 83, 109–126.CrossRefGoogle Scholar
  44. Sullivan, M. F., Ruemmler, P. S., Ryan, J. L., & Buschbom, R. L. (1986). Influence of oxidizing or reducing agents on gastrointestinal absorption of U, Pu, Am, Cm and Pm by rats. Health Physics, 50(2), 223–232.CrossRefGoogle Scholar
  45. UNSCEAR. (2011). Sources, effects and risks of ionizing radiation (p. 45). New York: United Nations.Google Scholar
  46. USEPA. (1999). Draft guidelines for carcinogen risk assessment (Review Draft, July 1999), Washington.Google Scholar
  47. USEPA. (2000). National primary drinking water regulation, radio nuclides. Final Rule, 40 CFR Parts 9, 141 and 142.76708- 76712.Google Scholar
  48. USEPA. (2003). Current drinking water standards. Ground water and drinking water protection agency, pp 1–12.Google Scholar
  49. Vandenhove, H., Hurtgen, C., & Payne, T. (2010). Radio nuclides in the environment: Uranium. Radio nuclides in the environment (pp. 261–272). West Sussex: Wiley.Google Scholar
  50. WHO. (2004). Guidelines for drinking water quality (3rd ed., Vol. 1). Geneva: World Health Organization.Google Scholar
  51. WHO. (2011). Guidelines for drinking-water quality (4th ed.). Geneva: World Health Organization.Google Scholar
  52. Wrenn, M. E., Durbin, P. W., Howard, B., Lipsztein, J., Rundo, J., Still, E. T., et al. (1985). Metabolism of ingested U and Ra. Health Physics, 48(5), 601–633.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Environment Monitoring and Assessment Lab, Department of PhysicsDr. B. R. Ambedkar National Institute of TechnologyJalandharIndia

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