Occurrence of pharmaceuticals and personal care products, and their associated environmental risks in a large shallow lake in north China
Eighteen selected pharmaceuticals and personal care products (PPCPs), consisting of five non-antibiotic pharmaceuticals (N-APs), four sulfonamides (SAs), four tetracyclines (TCs), four macrolides (MCs), and one quinolone (QN) were detected in water, pore water, and sediment samples from Baiyangdian Lake, China. A total of 31 water samples and 29 sediment samples were collected in March 2017. Caffeine was detected with 100% frequency in surface water, pore water, and sediment samples. Carbamazepine was detected with 100% frequency in surface water and sediment samples. Five N-APs were prominent, with mean concentrations of 4.90–266.24 ng/l in surface water and 5.07–14.73 μg/kg in sediment samples. Four MCs were prominent, with mean concentrations of 0.97–29.92 ng/l in pore water samples. The total concentrations of the different classes of PPCPs followed the order: N-APs (53.26%) > MCs (25.39) > SAs (10.06%) > TCs (7.64%) > QNs (3.64%) in surface water; N-APs (42.70%) > MCs (25.43%) > TCs (14.69%) > SAs (13.90%) > QNs (3.24%) in sediment samples, and MCs (42.12%) > N-APs (34.80%) > SAs (11.71%) > TCs (7.48%) > QNs (3.88%) in pore water samples. The geographical differences of PPCP concentrations were largely due to anthropogenic activities. Sewage discharged from Baoding City and human activities around Baiyangdian Lake were the main sources of PPCPs in the lake. An environmental risk assessment for the upper quartile concentration was undertaken using calculated risk quotients and indicated a low or medium-high risk from 18 PPCPs in Baiyangdian Lake and its five upstream rivers.
KeywordsPharmaceuticals and personal care products (PPCPs) Baiyangdian Lake Occurrence Risk assessment
This work was supported by the Major Science and Technology Program for Water Pollution Control and Treatment (2012ZX07203-006) and (2018ZX07110-04), and Beijing Municipal Science and Technology Plan Project (Z171100000717010).
- Beretta, M., Britto, V., Tavares, T. M., Silva, S. M. T. D., & Pletsch, A. L. (2014). Occurrence of pharmaceutical and personal care products (PPCPs) in marine sediments in the Todos os Santos Bay and the north coast of Salvador, Bahia, Brazil. Journal of Soils and Sediments, 14, 1278–1286.CrossRefGoogle Scholar
- Chen, H., Li, X., & Zhu, S. (2012). Occurrence and distribution of selected pharmaceuticals and personal care products in aquatic environments: A comparative study of regions in China with different urbanization levels. Environmental Science and Pollution Research, 19, 2381–2389.CrossRefGoogle Scholar
- EPA. (2007). Method 1694: Pharmaceuticals and personal care products in water, soil, sediment, and biosolids by HPLC/MS/MS. http://www.caslab.com/EPAMethods/PDF/1694.pdf.
- European Commission. (2003). Technical Guidance Document on Risk Assessment. Part II. European Commission Joint Research Centre (EUR 20418 EN/2).Google Scholar
- FDA (Food and Drug Administration). (2013). Approved drug products with therapeutic equivalence evaluations. Rockville, MD: Center for Drug Evaluation and Research.Google Scholar
- Gottschall, N., Topp, E., Metcalfe, C., Edwards, M., Payne, M., Kleywegt, S., et al. (2012). Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field. Chemosphere, 87, 194–203.CrossRefGoogle Scholar
- Hawthorne, S. B., Grabanski, C. B., Miller, D. J., & Kreitinger, J. P. (2005). Solid-phase micro-extraction measurement of parent and alkyl polycyclic aromatic hydrocarbons in milliliter sediment pore water samples and determination of KDOC values. Environmental Science and Technology, 39, 2795–2803.CrossRefGoogle Scholar
- Jacobsen, A. M., Halling-Sørensen, B., & Hansen, S. H. (2004). Simultaneous extraction of tetracycline, macrolide and sulfonamide antibiotics from agricultural soils using pressurised liquid extraction, followed by solid-phase extraction and liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1038, 157–170.CrossRefGoogle Scholar
- Li, W. H., Gao, L. R., Shi, Y. L., Liu, J. M., & Cai, Y. Q. (2015). Occurrence, distribution and risks of antibiotics in urban surface water in Beijing, China. Environmental Science: Process Impacts, 17, 1611–1619.Google Scholar
- Xu, W. H., Zhang, G., Zou, S. C., Li, X. D., & Liu, Y. C. (2007). Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. Environmental Pollution, 145, 672–679.CrossRefGoogle Scholar
- Yang, X., Chen, F., Meng, F. G., Xie, Y. Y., Chen, H., Young, K., et al. (2013). Occurrence and fate of PPCPs and correlations with water quality parameters in urban riverine waters of the Pearl River Delta, South China. Environmental Science and Pollution Research, 20, 5864–5875.CrossRefGoogle Scholar