Ecotoxicology

, Volume 19, Issue 4, pp 662–669 | Cite as

Implication of global environmental changes on chemical toxicity-effect of water temperature, pH, and ultraviolet B irradiation on acute toxicity of several pharmaceuticals in Daphnia magna

  • Jungkon Kim
  • Jeongim Park
  • Pan-Gyi Kim
  • Chulwoo Lee
  • Kyunghee Choi
  • Kyungho Choi
Article

Abstract

Global environmental change poses emerging environmental health challenges throughout the world. One of such threats could be found in chemical safety in aquatic ecosystem. In the present study, we evaluated the effect of several environmental factors, such as water pH, temperature and ultraviolet light on the toxicity of pharmaceutical compounds in water, using freshwater invertebrate Daphnia magna. Seven pharmaceuticals including ibuprofen, acetaminophen, lincomycin, ciprofloxacin, enrofloxacin, chlortetracycline and sulfathiazole were chosen as test compounds based on their frequent detection in water. The experimental conditions of environmental parameters were selected within the ranges that could be encountered in temperate environment, i.e., water temperature (15, 21, and 25°C), pH (7.4, 8.3, and 9.2), and UV-B light intensity (continuous irradiation of 15.0 μW/cm2). For acetaminophen, enrofloxacin and sulfathiazole, decrease in water pH generally led to increase of acute lethal toxicity, which could be explained by the unionized fraction of pharmaceuticals. Increase of water temperature enhanced the acute toxicity of the acetaminophen, enrofloxacin and chlortetracycline, potentially due to alteration in toxicokinetics of chemicals as well as impact on physiological mechanisms of the test organism. The presence of UV-B light significantly increased the toxicity of sulfathiazole, which could be explained by photo-modification of this chemical that lead to oxidative stress. Under the UV light, however, acute toxicity of enrofloxacin decreased, which might be due to photo-degradation. Since changing environmental conditions could affect exposure and concentration-response profile of environmental contaminants, such conditions should be identified and evaluated in order to better manage ecosystem health under changing global environment.

Keywords

Climate change Daphnia magna pH Pharmaceutical Temperature Ultraviolet-B light 

Supplementary material

10646_2009_440_MOESM1_ESM.pdf (133 kb)
Supplementary material Tables showing toxicity values obtained from different temperature and UV-B light conditions are provided as supplementary materials. (PDF 132 kb)

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Jungkon Kim
    • 1
  • Jeongim Park
    • 2
  • Pan-Gyi Kim
    • 3
  • Chulwoo Lee
    • 4
  • Kyunghee Choi
    • 4
  • Kyungho Choi
    • 1
  1. 1.Institute of Health and Environment, School of Public HealthSeoul National UniversitySeoulKorea
  2. 2.Department of Environmental HealthSoonchunhyang UniversityAsanKorea
  3. 3.Department of Occupational and Environmental HealthYongin UniversityYonginKorea
  4. 4.National Institute of Environmental ResearchIncheonKorea

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