Investigational New Drugs

, Volume 36, Issue 6, pp 1116–1132 | Cite as

Emerging roles of non-coding RNAs in the pathogenesis, diagnosis and prognosis of osteosarcoma

  • Chongchong Wang
  • Juehua Jing
  • Li Cheng


Non-coding RNAs (ncRNAs) have been found to play essential roles in various physiological and pathological processes. The involvement of ncRNAs in the development of osteosarcoma (OS) has been explored in recent years. In this review, we summarize the functions and mechanisms of microRNA, lncRNA and circRNA in the initiation and progression of OS. We specifically focused on their potential application in the diagnosis, prognosis and therapy of OS. This summary of current knowledge on the involvement of ncRNAs in OS will not only aid comprehension of the complex processes of OS initiation and progression but also contribute to the exploration of ideal diagnostic biomarkers and therapeutic targets for OS patients.


Osteosarcoma microRNAs Long non-coding RNAs circRNAs 



This work is supported by the National Natural Science Foundation of China (81702656) and the Natural Science Foundation of Anhui Province (1708085QH215) to Li Cheng.

Compliance with ethical standards

Conflict of interest

Chongchong Wang declares that she has no conflict of interest. Juehua Jing declares that he has no conflict of interest. Li Cheng declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of OncologyThe Fourth Affiliated Hospital of Anhui Medical UniversityHefeiChina
  2. 2.Department of OrthopaedicsThe Second Affiliated Hospital of Anhui Medical UniversityHefeiChina

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