Investigational New Drugs

, Volume 35, Issue 4, pp 509–517 | Cite as

Lung cancer and β-glucans: review of potential therapeutic applications

REVIEW

Summary

The potential of natural substances with immunotherapeutic properties has long been studied. β-glucans, a cell wall component of certain bacteria and fungi, potentiate the immune system against microbes and toxic substances. Moreover, β-glucans are known to exhibit direct anticancer effects and can suppress cancer proliferation through immunomodulatory pathways. Mortality of lung cancer has been alarmingly increasingly worldwide; therefore, treatment of lung cancer is an urgent necessity. Numerous researchers are now dedicated to using β-glucans as a therapy for lung cancer. In the present attempt, we have reviewed the studies addressing therapeutic effects of β-glucans in primary and metastatic lung cancer published in the time period of 1991–2016.

Keywords

Lung cancer β-glucans Immunomodulatory activity Drug resistance 

Notes

Compliance with ethical standards

Conflict of interest

Raheleh Roudi declares that she has no conflict of interest.

Shahla Roudbar Mohammadi declares that she has no conflict of interest.

Maryam Roudbary declares that she has no conflict of interest.

Monireh Mohsenzadegan declares that she has no conflict of interest.

Funding

No.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Oncopathology Research CenterIran University of Medical SciencesTehranIran
  2. 2.Department of Medical Mycology, Faculty of Medical SciencesTarbiat Modares UniversityTehranIran
  3. 3.Department of Medical Mycology and Parasitology, School of MedicineIran University of Medical SciencesTehranIran
  4. 4.Department of Medical Laboratory Science, Faculty of Allied Medical SciencesIran University of Medical SciencesTehranIran

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