Investigational New Drugs

, Volume 30, Issue 4, pp 1641–1645

Topical treatment of cutaneous metastases of malignant melanoma using combined imiquimod and 5-fluorouracil

  • Valerie Florin
  • Eve Desmedt
  • Sophie Vercambre-Darras
  • Laurent Mortier
PHASE II STUDIES

DOI: 10.1007/s10637-011-9717-2

Cite this article as:
Florin, V., Desmedt, E., Vercambre-Darras, S. et al. Invest New Drugs (2012) 30: 1641. doi:10.1007/s10637-011-9717-2

Summary

Background Despite multiple available options, the treatment of cutaneous melanoma metastases is often unsuccessful. Based on the hypothesis that imiquimod and 5-fluorouracil have synergistic antitumor properties, we used this topical combination to treat several patients. Aim Our objective was to investigate the treatment combination in a small cohort of patients with surgically non-resectable melanoma metastases. Methods The lesions of 5 patients with multiple cutaneous metastases were treated topically, 5 days per week, with 5-fluorouracil in the morning and imiquimod at night. Results 45 lesions were treated. A clinical response was seen in 44 lesions, with a complete response in 19 lesions and a partial response in 25. Stable disease was confirmed in the 1 remaining lesion. No patients developed new lesions during treatment. However, one patient had a recurrence 6 months after treatment discontinuation, followed by a partial response when rechallenged. Conclusions The imiquimod and 5-fluorouracil combination is effective. That patients did not develop new, distant lesions suggests the achievement of locoregional control, probably by the induction of antitumor immune response.

Keywords

Imiquimod 5-fluorouracil Melanoma Skin metastases Tumor immunology 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Valerie Florin
    • 1
  • Eve Desmedt
    • 1
  • Sophie Vercambre-Darras
    • 1
  • Laurent Mortier
    • 1
    • 2
  1. 1.Department of Dermatology, Claude-Huriez HospitalUniversity Hospital of LilleLilleFrance
  2. 2.Service de DermatologieHôpital Claude-Huriez, CHRULille cedexFrance

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