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Reversible cardiogenic shock following 5-Fluorouracil infusion

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Summary

5-fluorouracil remains a major component of chemotherapy regimens for various tumors. We report the case of reversible cardiogenic shock following 5-FU administration and discuss the different pitfalls of such toxicity. Oncologist should be aware of that rare but potentially lethal adverse event.

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Acknowledgement

The authors thank Lorna Saint Ange for editing.

Author information

Correspondence to Jean-Charles Soria.

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Transthoracic echocardiography performed at H18 after 5FU infusion: apical 4 chamber view showing global hypokinesia with a severe LVEF dysfunction measured at 35 %. (MPEG 1204 kb)

Panel 1

Transthoracic echocardiography performed before chemotherapy: apical 4 chamber view showing normal left ventricular ejection fraction (60%). (MPEG 460 kb)

Panel 2

Transthoracic echocardiography performed at H18 after 5FU infusion: apical 4 chamber view showing global hypokinesia with a severe LVEF dysfunction measured at 35 %. (MPEG 1204 kb)

Panel 3

Transthoracic echocardiography performed at Day 7: apical 4 chamber view showing a complete normalization of LVEF (60%). (MPEG 430 kb)

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Ferté, C., Gomez Roca, C., Loriot, Y. et al. Reversible cardiogenic shock following 5-Fluorouracil infusion. Invest New Drugs 28, 531–533 (2010) doi:10.1007/s10637-009-9271-3

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Keywords

  • 5-Fluorouracil
  • Cardiogenic shock
  • Toxicity