Investigational New Drugs

, Volume 23, Issue 3, pp 241–242 | Cite as

A phase I trial of irinotecan (CPT-11) with amifostine in patients with metastatic colorectal cancer

  • Heather WakeleeEmail author
  • George A. Fisher

Key words

amifostine irinotecan phase I colorectal cancer 


  1. 1.
    Rothenberg M, Eckardt J, Kuhn J, Burris H, Nelson J, Hilsengeck S, Rodriguez G, Thurman A, Smith L, Eckardt S, Weiss G, Elfring G, Rinaldi D, Schaaf L, Von Hoff D: Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J Clin Oncol 14: 1128–1135, 1996PubMedGoogle Scholar
  2. 2.
    de Forni M, Bugat R, Chabot G, Culine S, Extra J-M, Gouyette A, Madelaine I, Marty M, Mathieu-Boué A: Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients. Cancer Res 54: 4347–4354, 1994PubMedGoogle Scholar
  3. 3.
    Kemp G, Rose P, Lurain J, Berman M, Manetta A, Roullet B, Homesley H, Belpomme D, Glick J: Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer. J Clin Oncol 14: 2101–2112, 1996PubMedGoogle Scholar
  4. 4.
    Millar JL, McElain TJ, Clutterbuck RD, Wist EA: The modification of melphalan toxicity in tumor bearing mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721). Am J Clin Oncol 5: 321–328, 1982PubMedGoogle Scholar
  5. 5.
    Rougier P, Bugat R, Douillard JY, Culine S, Suc E Brunet P, Becouarn Y, Ychou M, Marty M, Extra JM, Bonneterre J, Adenis A, Seitz JF, Ganem G, Namer M, Conroy T, Negrier S, Merrouche Y, Burki F, Mousseau M, Herait P, Mahjoubi M: Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J Clin Oncol 15: 251–260, 1997PubMedGoogle Scholar
  6. 6.
    Delioukina ML, Prager D, Parson M, Hecht JR, Rosen P, Rosen LS: Phase II trial of irinotecan in combination with amifostine in patients with advanced colorectal carcinoma. Cancer 94: 2174–2179, 2002CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Stanford Clinical Cancer CenterStanfordUSA
  2. 2.Stanford

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