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Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years

  • Jana SzanyiEmail author
  • Jan Kremlacek
  • Zuzana Kubova
  • Miroslav Kuba
  • Pavel Gebousky
  • Jaroslav Kapla
  • Juraj Szanyi
  • Frantisek Vit
  • Jana Langrova
Original Research Article
  • 8 Downloads

Abstract

Purpose

The aim of this neurophysiological study was to monitor changes in the visual and cognitive function of HIV-infected patients treated with combination antiretroviral therapy.

Methods

Eleven adult Czech HIV+ patients, with a mean age of 35 years and CD4 cell count ≥ 230 × 106 cells/L of blood at the time of enrollment, underwent four to six examinations over the course of 2.5 years to evaluate pattern-reversal and motion-onset visual evoked potentials (P-VEPs and M-VEPs), visually driven oddball event-related potentials (ERPs) and Montreal Cognitive Assessments. In addition to evaluating the intraindividual change in the observed parameters, we also compared patient data to data from eleven age- and gender-matched controls.

Results

We did not find any significant differences in P-VEPs between the patients and controls or in the paired comparison of the first and last visit. The only significant finding for P-VEPs was a linear trend in prolongation of the 20′ P-VEP P100 peak time. In M-VEPs, we found a significant intergroup difference in the N160 peak time recorded during the first visit for peripheral M-VEPs only. During the last visit, all N160 peak times for patients differed significantly from those of the control group. The only intervisit difference close to the level of significance was for peripheral M-VEPs, which confirmed the trend analysis. No significant differences between patients and controls were found in the ERPs, but the P300 peak time showed a significant difference between the first and last visits, as confirmed by the trend. Patient reaction time was not significantly delayed at the first visit; however, it was prolonged with time, as confirmed by the trend.

Conclusion

Our aim was to evaluate whether antiretroviral treatment in HIV+ patients is sufficient to preserve brain visual function. The optic nerve and primary visual cortex function tested by the P-VEPs seem to be preserved. The prolongation of the M-VEPs suggests an individually detectable decline in CNS function, but these changes did not show a progression during the follow-up. From a longitudinal perspective, the trends in peak time prolongation of the 20′ P-VEP, peripheral M-VEP, ERP and reaction time suggest a faster decline than that caused by aging in healthy populations, as previously described in a cross-sectional study.

Keywords

Human immunodeficiency virus (HIV) Visual evoked potentials (VEPs) Motion-onset VEP Pattern-reversal VEP Event-related potentials (ERPs) 

Notes

Acknowledgements

Supported by Charles University in Prague, Czech Republic, project Progress Q40/07.

Compliance with ethical standards

Conflict of interest

There are no conflicts of interest for any of the authors. The authors have nothing to disclose. J.S., J.K., Z.K., M.K., P.G., J.S., F.V. and J.L. were supported by a grant from Charles University in Prague, Czech Republic - Progress Q40/07.

Statement of human rights

The experiment was performed only on humans and was procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation. The Ethical Committee of the University Hospital in Hradec Kralove gave ethical approval. All experiments were conducted in accordance with the Declaration of Helsinki.

Informed consent

Informed consent for the electrophysiological examination was obtained from each subject.

Statement on the welfare of animals

No animals were used in this study.

Ethical approval

The Ethical Committee of the University Hospital in Hradec Kralove gave ethical approval. All experiments were conducted in accordance with the Declaration of Helsinki.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Pathological PhysiologyCharles University - Faculty of Medicine in Hradec KraloveHradec KraloveCzech Republic
  2. 2.Department of Infectious DiseasesFaculty Hospital in Hradec KraloveHradec KraloveCzech Republic
  3. 3.Department of Epidemiology, Faculty of Military Health SciencesUniversity of Defence in Hradec KraloveHradec KraloveCzech Republic

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