Documenta Ophthalmologica

, Volume 130, Issue 1, pp 25–30 | Cite as

Diagnostic value of visual evoked potentials for clinical diagnosis of multiple sclerosis

  • Niphon ChirapapaisanEmail author
  • Sawarin Laotaweerungsawat
  • Wanicha Chuenkongkaew
  • Patthanee Samsen
  • Ngamkae Ruangvaravate
  • Atiporn Thuangtong
  • Nacha Chanvarapha
Original Research Article



Prolonged latency of visual evoked potentials (VEP) has been used to identify clinically silent lesions in multiple sclerosis (MS) suspects. The objective of this study was to determine the reliability of VEP to predict the development of MS in MS suspects.


Retrospective hospital records of MS suspects were evaluated. VEP was analyzed together with subsequent diagnostic confirmation of MS by McDonald diagnostic criteria for MS-2005.


MS developed in 12 of 35 patients (34 %) and 23 (66 %) failed to exhibit diagnostic characteristics. P100 latencies and interocular latency differences were longer in clinically definite multiple sclerosis (CDMS) than non-CDMS patients (p = 0.002, 0.001, respectively). All patients in the subsequent MS group had P100 latencies longer than102 ms, a mean of our MS-free subjects thus providing 100 % of sensitivity. No patient developed MS with a P100 latency <102 ms. Brain MRI lesions associated significantly with developing CDMS (p = 0.001). Predictability of developing CDMS was highest when criteria for P100 latency, interocular latency difference, and brain MRI lesions were combined.


MS suspects with a P100 latency longer than mean of MS-free subjects are more likely to develop MS than those with lower values. VEP latency combined with MRI could improve the accuracy of MS prediction.


Visual evoked potentials Optic neuritis Multiple sclerosis MRI Demyelination 



We would like to thank Ms. Julaporn Pooliam, MS.C for the statistical calculations ,and Dr. William Beamish in reviewing of this manuscript.

Conflict of interest

The authors declare that there is no conflict of interest.

Ethical standard

The Institutional Review Board of Siriraj Hospital.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Niphon Chirapapaisan
    • 1
    Email author
  • Sawarin Laotaweerungsawat
    • 1
  • Wanicha Chuenkongkaew
    • 1
  • Patthanee Samsen
    • 1
  • Ngamkae Ruangvaravate
    • 1
  • Atiporn Thuangtong
    • 1
  • Nacha Chanvarapha
    • 1
  1. 1.Department of Ophthalmology, Faculty of Medicine, Siriraj HospitalMahidol UniversityBangkoknoi, BangkokThailand

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