Documenta Ophthalmologica

, Volume 121, Issue 2, pp 161–166 | Cite as

Macular vitelliform lesion in desferrioxamine-related retinopathy

  • Mohamed A. Genead
  • Gerald A. Fishman
  • Anastasios Anastasakis
  • Martin Lindeman
Case report


To report a case of a macular vitelliform lesion associated with desferrioxamine treatment. Ocular, electrophysiological, psychophysical, perimetric, fluorescein angiographic, fundus autofluorescence, and spectral-domain OCT examinations were obtained on a 45-year-old Caucasian woman with thalassemia major treated with blood transfusions and desferrioxamine. The patient was observed to have a vitelliform macular lesion in the right eye with a hypopigmented macular lesion and retinal pigment mottling in the left. At the most recent follow-up visit, best-corrected visual acuity was 20/70 in the right eye and 20/25 in left. Full-field electroretinogram (ERG) testing showed normal cone and rod responses. Mild localized elevations of rod psychophysical thresholds were found. A vitelliform macular lesion can develop in patients treated with desferrioxamine. Some such patients may not show diffuse photoreceptor cell functional loss as determined by electrophysiological testing.


Desferrioxamine toxicity Macular vitelliform lesion Electroretinogram measurement 



Supported by funds from the Foundation Fighting Blindness, Owings Mills, Maryland; Grant Healthcare Foundation, Lake Forest, Illinois; NIH core grant EYO1792; and an unrestricted departmental grant from Research to Prevent Blindness.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Mohamed A. Genead
    • 1
  • Gerald A. Fishman
    • 1
  • Anastasios Anastasakis
    • 1
  • Martin Lindeman
    • 1
  1. 1.Department of Ophthalmology and Visual Sciences (MC 648)University of Illinois at ChicagoChicagoUSA

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