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Documenta Ophthalmologica

, Volume 114, Issue 1, pp 1–7 | Cite as

Intraocular triamcinolone acetonide for macular edema due to CRVO. A multifocal-ERG and OCT study

  • Marilita M. MoschosEmail author
  • Dimitrios Brouzas
  • Eleni Loukianou
  • Michael Apostolopoulos
  • Michael Moschos
Original Paper

Abstract

Purpose

To investigate the effectiveness of intravitreal triamcinolone acetonide in the treatment of cystoid macular edema due to central retinal vein occlusion (CRVO). A noncomparative, prospective, interventional case series.

Methods

In this study 15 eyes of 15 patients (9 males and 6 females) with macular edema due to non-ischemic CRVO were treated with intravitreal injection of 4 mg triamcinolone acetonide and followed-up for 1 year. Examination included measurement of best-corrected visual acuity (BCVA) for distance, measurement of intraocular pressure (IOP), fluorescein angiography, foveal retinal thickness measurement by optical coherence tomography (OCT), and multifocal electroretinography recordings (MFERG) preoperatively 3, 6 and 12 months postoperatively.

Results

The visual acuity increased to a significant degree at 3 months, to a smaller degree at 6 months but at 12 months there was no significant improvement. The OCT macula thickness improved to a significant level all the follow-up period but with less significance at 12 months. The MFERG recordings from the fovea showed significant improvement at 3 and 6 months. The MFERG from the parafovea area showed significant improvement at 3 and 6 and to a smaller degree at 12 months. The intraocular pressure increased at 3 and 6 months but returned to pretreatment level at 12 months.

Conclusion

Intravitreal injection of triamcinolone acetonide leads to a significant improvement of mean VA in patients with macular edema due to CRVO. However, this significant effect is not permanent and persists for a maximum of 3–6 months. Thereafter all the indexes tend to deteriorate.

Keywords

Triamcinolone acetonide Multifocal Electroretinogram (MFERG) Optical Coherence Tomography (OCT) Central retinal vein occlusion (CRVO) 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Marilita M. Moschos
    • 1
    • 2
    Email author
  • Dimitrios Brouzas
    • 1
  • Eleni Loukianou
    • 1
  • Michael Apostolopoulos
    • 1
  • Michael Moschos
    • 1
  1. 1.Department of OphthalmologyUniversity of AthensAthensGreece
  2. 2.PiraeusGreece

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