Documenta Ophthalmologica

, Volume 114, Issue 1, pp 1–7 | Cite as

Intraocular triamcinolone acetonide for macular edema due to CRVO. A multifocal-ERG and OCT study

  • Marilita M. MoschosEmail author
  • Dimitrios Brouzas
  • Eleni Loukianou
  • Michael Apostolopoulos
  • Michael Moschos
Original Paper



To investigate the effectiveness of intravitreal triamcinolone acetonide in the treatment of cystoid macular edema due to central retinal vein occlusion (CRVO). A noncomparative, prospective, interventional case series.


In this study 15 eyes of 15 patients (9 males and 6 females) with macular edema due to non-ischemic CRVO were treated with intravitreal injection of 4 mg triamcinolone acetonide and followed-up for 1 year. Examination included measurement of best-corrected visual acuity (BCVA) for distance, measurement of intraocular pressure (IOP), fluorescein angiography, foveal retinal thickness measurement by optical coherence tomography (OCT), and multifocal electroretinography recordings (MFERG) preoperatively 3, 6 and 12 months postoperatively.


The visual acuity increased to a significant degree at 3 months, to a smaller degree at 6 months but at 12 months there was no significant improvement. The OCT macula thickness improved to a significant level all the follow-up period but with less significance at 12 months. The MFERG recordings from the fovea showed significant improvement at 3 and 6 months. The MFERG from the parafovea area showed significant improvement at 3 and 6 and to a smaller degree at 12 months. The intraocular pressure increased at 3 and 6 months but returned to pretreatment level at 12 months.


Intravitreal injection of triamcinolone acetonide leads to a significant improvement of mean VA in patients with macular edema due to CRVO. However, this significant effect is not permanent and persists for a maximum of 3–6 months. Thereafter all the indexes tend to deteriorate.


Triamcinolone acetonide Multifocal Electroretinogram (MFERG) Optical Coherence Tomography (OCT) Central retinal vein occlusion (CRVO) 


  1. 1.
    The Central Vein Occlusion Study Group (1997) Natural history and clinical management of central retinal vein occlusion. Arch Ophthalmol 115:486–491Google Scholar
  2. 2.
    The Central Vein Occlusion Study Group (1995) Evaluation of grid laser pattern photocoagulation for macular edema in central vein occlusion. Ophthalmology 102:1425–1433Google Scholar
  3. 3.
    Greenberg PB, Martinis A, Roger AH, Duker JS, Reichel E (2002) Intravitreal triamcinolone acetonide for macular edema due to central retinal vein occlusion. Br J Ophthalmol 86:247–248PubMedCrossRefGoogle Scholar
  4. 4.
    Ip SM, Kumar KS (2002) Intravitreal triamcinolone acetonide as treatment for macular edema from central retinal vein occlusion. Arch Ophthalmol 120:1217–1219PubMedGoogle Scholar
  5. 5.
    Ip M, Kahama A, Altaweel M (2003) Treatment of central retinal vein occlusion with triamcinolone acetonide: an optical coherence tomography study. Semin Ophthalmol 18:67–73PubMedCrossRefGoogle Scholar
  6. 6.
    Park CH, Jaffe GJ, Fekrat S (2003) Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol 136:419–425PubMedCrossRefGoogle Scholar
  7. 7.
    Sutter E, Tran D (1992) The field topography of ERG components in man-I. The photopic luminance response. Vision Res 32:433–446PubMedCrossRefGoogle Scholar
  8. 8.
    Hood D (2000) Assessing retinal function with the multifocal technique. Prog Ret Eye Res 19:607–646CrossRefGoogle Scholar
  9. 9.
    Marmor MF, Hood DC, Keating D, Kondo M, Seeliger MW, Miyake Y (2003) International society for clinical electrophysiology of vision. Guidelines for basic multifocal electroretinography (mfERG). Doc Ophthalmol 106(3):338CrossRefGoogle Scholar
  10. 10.
    Jones JB, Hayler JK, Solker A, Pauda-Jonas S (2001) Intravitreal injection of crystalline cortisone as an adjunctive treatment for proliferative diabetic retinopathy. Am J Ophthalmol 131:468–471CrossRefGoogle Scholar
  11. 11.
    Kitazawa Y, Horie T (1981) The prognosis of corticosteroid-responsive individuals. Arch Ophthalmol 99:819–823PubMedGoogle Scholar
  12. 12.
    Williamson T, O’Donnell A (2005) Intravitreal triamcinolone acetonide for cystoid macular edema in nonischemic central retinal vein occlusion. Am J Ophthalmol 139:860–866PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Marilita M. Moschos
    • 1
    • 2
    Email author
  • Dimitrios Brouzas
    • 1
  • Eleni Loukianou
    • 1
  • Michael Apostolopoulos
    • 1
  • Michael Moschos
    • 1
  1. 1.Department of OphthalmologyUniversity of AthensAthensGreece
  2. 2.PiraeusGreece

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