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Magnetic Steering of Capsule Endoscopy Improves Small Bowel Capsule Endoscopy Completion Rate

  • Yuan-Yuan Luo
  • Jun Pan
  • Yi-Zhi Chen
  • Xi Jiang
  • Wen-Bin Zou
  • Yang-Yang Qian
  • Wei Zhou
  • Xiao Liu
  • Zhao-Shen LiEmail author
  • Zhuan LiaoEmail author
Original Article
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Abstract

Background

Capsule endoscopy is currently available as a noninvasive and effective diagnostic modality to identify small bowel abnormalities, with a completion rate to the cecum between 75.1 and 95.6%. A novel magnetically controlled capsule endoscopy (MCE) system could facilitate passage of the capsule through the pylorus, thereby reducing the gastric transit time (GTT).

Objective

We performed this study to determine whether magnetic steering could improve the capsule endoscopy completion rate (CECR) compared to standard protocol.

Methods

Patients referred for MCE in our center from June 2017 to November 2017 were prospectively enrolled. Magnetic steering of the capsule through the pylorus was performed after standard gastric examination. CECR, GTT, pyloric transit time (PTT), and rapid gastric transit (GTT ≤ 30 min) rate were compared with a historical control group enrolled from January 2017 to May 2017.

Results

CECR was significantly higher in the intervention group (n = 107) than control group (n = 120) (100% vs. 94.2%, P = 0.02), with a significantly shorter GTT (22.2 vs. 84.5 min, P < 0.001) and PTT (4.4 vs. 56.7 min, P < 0.001). Rapid gastric transit rate in the intervention group was significantly higher than the control group (58.9% vs. 15.0%, P < 0.001). There were no statistical differences in the diagnostic yields between the two groups.

Conclusions

Magnetic steering of capsule endoscopy improves small bowel CECR by reducing GTT, adding further support to MCE as a practical tool for noninvasive examination of both the stomach and small bowel.

Trial registration ClinicalTrials.gov, ID: NCT03482661.

Keywords

Magnetic steering Capsule endoscopy Small bowel Completion rate 
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Notes

Author’s contribution

ZL was involved in study concept and design; YYL and JP contributed to registration of the study; YYL, JP, and YZC conducted the study; YYL, XJ, WBZ, YYQ, WZ, and XL contributed to acquisition of data; YYL, JP, and YZC analyzed and interpreted data; JP and YZC drafted the manuscript; YYL contributed to statistical analysis; ZL and ZSL critically revised the manuscript for important intellectual content; and ZL and JP contributed to the funding. All authors had access to the study data and reviewed and approved the final manuscript.

Funding

This study is supported by grants from the National Natural Science Foundation of China (to Z. Liao, No. 81422010); Foundation for the Author of National Excellent Doctoral Dissertation of China (to Z. Liao, No. 201271); the Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission (to Z. Liao, No. 15SG33); the Chang Jiang Scholars Program of Ministry of Education (to Z. Liao, No. Q2015190); and Shanghai Sailing Program (to J. Pan, No. 18YF1422800), China. All other authors disclosed no financial relationships relevant to this publication.

Compliance with ethical standards

Conflicts of interest

None.

Supplementary material

10620_2019_5479_MOESM1_ESM.tif (15 mb)
The NaviCam magnetic control system. (A) Guidance magnet robot and computer workstation for real-time viewing and controlling; (B) the capsule endoscope (TIFF 15324 kb)
10620_2019_5479_MOESM2_ESM.tif (7.2 mb)
MCE findings of the stomach. (A) Erosive gastritis; (B) gastric polyp; (C) chronic non-atrophic gastritis; and (D) gastric ulcer (TIFF 7415 kb)
10620_2019_5479_MOESM3_ESM.tif (10 mb)
MCE findings of the colon. (A) Colonic polyp; (B) parasites; and (C) colitis (TIFF 10289 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Yuan-Yuan Luo
    • 1
  • Jun Pan
    • 1
  • Yi-Zhi Chen
    • 1
  • Xi Jiang
    • 1
  • Wen-Bin Zou
    • 1
  • Yang-Yang Qian
    • 1
  • Wei Zhou
    • 1
  • Xiao Liu
    • 1
  • Zhao-Shen Li
    • 1
    Email author
  • Zhuan Liao
    • 1
    Email author
  1. 1.National Clinical Research Center for Digestive Diseases, Department of Gastroenterology, Changhai HospitalSecond Military Medical UniversityShanghaiChina

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