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Updated Assessment of Colorectal Cancer Incidence in the U.S. by Age, Sex, and Race/Ethnicity

  • Ajay Ohri
  • Ann Robinson
  • Benny Liu
  • Taft Bhuket
  • Robert WongEmail author
Original Article
  • 11 Downloads

Abstract

Background

Whether recent updates to colon cancer screening guidelines benefit men and women or all race/ethnic groups equally is not clear.

Aims

The aim of this study is to evaluate age-, sex-, and race/ethnicity-specific trends in CRC incidence and disease burden among adults.

Methods

Using 2000–2014 surveillance, epidemiology, and end results database, annual CRC incidence (per 100,000 persons/year) among U.S. adults was categorized by age (using 10-year age intervals) and stratified by sex and race/ethnicity. Comparison of incidence between groups utilized the z-statistic with p < 0.05 indicating statistical significance.

Results

Overall, CRC incidence was the highest among patients aged ≥ 80 years (330.8 per 100,000 persons/year), which was significantly higher in men versus women (377.2 vs. 304.3 per 100,000 persons/year, p < 0.001). CRC incidence in younger individuals was 22.8 per 100,000 persons/year (age 40–49) and 6.8 per 100,000 persons/year (age 30–39). CRC incidence was significantly higher in African Americans compared to non-Hispanic whites. From 2000 to 2014, CRC incidence declined in all age groups over age 60, remained stable in age 50–59, and demonstrated proportional increases in among age 20–49 years. While CRC incidence in all race/ethnic groups aged ≥ 60 years declined, Hispanics aged 50–59 increased 21.9%, but remained stable in other race/ethnic groups. Race/ethnicity-specific disparities in CRC incidence in patients aged 20–49 were also observed.

Conclusions

While CRC incidence has declined among U.S. adults aged ≥ 60, increasing incidence among patients aged < 50 is concerning. Identifying risk factors among “average-risk” patients is needed to better implement targeted screening of individuals not currently meeting CRC screening criteria.

Keywords

Colon cancer SEER Epidemiology Race/ethnicity 

Abbreviations

CRC

Colorectal cancer

U.S.

United States

SEER

Surveillance, epidemiology, and end results

APC

Annual percentage change

BAPC

Biannual percentage change

Notes

Author’s contribution

RW guarantor of the article. RW and AO: involved in study concept and design. RW involved in acquisition of data. AO, AR, BL, TB, and RW involved in analysis and interpretation of data. AO and RW involved in statistical analysis. AO and RW involved in drafting of the manuscript. AO, AR, BL, TB, and RW involved in critical revision of the manuscript for important intellectual content. RW involved in study supervision. RW had full access to all the data in the study and took responsibility for the integrity of the data and accuracy of the data analysis.

Funding

No funding was provided for this study. Robert Wong is supported by an AASLD Foundation Clinical and Translational Research Award in Liver Diseases.

Compliance with Ethical Standards

Conflict of interest

Robert J. Wong: Advisory board, consultant, speaker’s bureau, and research Grants—Gilead Sciences; Speakers bureau: Salix, Bayer; Research Grant: Abbvie. Ajay Ohri, Ann Robinson, Benny Liu, Taft Bhuket: None.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Internal MedicineAlameda Health System – Highland HospitalOaklandUSA
  2. 2.Division of Gastroenterology and Hepatology, Endoscopy UnitAlameda Health System – Highland Hospital CampusOaklandUSA

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