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Digestive Diseases and Sciences

, Volume 64, Issue 12, pp 3394–3401 | Cite as

Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?

  • Margaret Morrison
  • Heather Y. Hughes
  • Susanna Naggie
  • Wing-Kin SynEmail author
Review
  • 104 Downloads

Abstract

Purpose of Review

Liver disease is a leading cause of non-AIDS-related death in the HIV population since the introduction of highly active antiretroviral treatment (HAART). Recent studies suggest that patients with HIV are at high risk for nonalcoholic fatty liver disease (NAFLD) and progressive liver fibrosis. Evidence for the prevalence, risk factors, and diagnostic methodologies of NAFLD in patients with HIV mono-infection is summarized here.

Recent Findings

Although limited, published studies suggest that the prevalence of NAFLD is higher (30–50%) and progresses at an increased rate in patients with HIV compared to the general population. Identifying those at risk for significant liver fibrosis is critical, preferably with non-invasive screening tests. While there is a paucity of evidence in this population, transient elastography (TE) appears to provide a sensitive, non-invasive screening modality.

Summary

Identifying NAFLD early will allow for dietary and lifestyle interventions, as well as future drug therapies to decrease the risk of progressive liver fibrosis and cirrhosis in the high-risk HIV population. Clinicians should be aware of this risk and consider using TE for NAFLD diagnosis and surveillance.

Keywords

NAFLD NASH HIV Transient elastography 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interests.

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2019

Authors and Affiliations

  1. 1.Division of General Internal MedicineMedical University of South CarolinaCharlestonUSA
  2. 2.Section of Infectious Diseases, Department of MedicineRalph H. Johnson VAMCCharlestonUSA
  3. 3.Divison of Infectious Diseases, Department of MedicineMedical University of South CarolinaCharlestonUSA
  4. 4.Division of Infectious Diseases, Department of MedicineDuke University School of MedicineDurhamUSA
  5. 5.Division of Infectious Diseases, Department of MedicineDurham VAMCDurhamUSA
  6. 6.Section of Gastroenterology and HepatologyRalph H. Johnson VAMCCharlestonUSA
  7. 7.Division of Gastroenterology and Hepatology, Department of MedicineMedical University of South CarolinaCharlestonUSA
  8. 8.Department of Physiology, Faculty of Medicine and NursingUniversity of Basque Country UPV/EHULeioaSpain

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