Digestive Diseases and Sciences

, Volume 64, Issue 12, pp 3616–3622 | Cite as

A Prospective Study on Contrast-Enhanced Endoscopic Ultrasound for Differential Diagnosis of Pancreatic Cystic Neoplasms

  • Lisen Zhong
  • Ningli Chai
  • Enqiang LinghuEmail author
  • Huikai Li
  • Jing Yang
  • Ping Tang
Original Article


Background and Aims

To determine the value of contrast-enhanced endoscopic ultrasound (CE-EUS) for differentiation of pancreatic cystic neoplasms (PCNs).


From April 2015 to December 2017, 82 patients were enrolled in this study. All patients were confirmed to have PCNs by surgical pathology. Prior to surgery, all patients underwent fundamental B-mode EUS (FB-EUS) and CE-EUS, 65 of whom underwent computed tomography (CT) and 71 of whom underwent magnetic resonance imaging (MRI). The enhanced mode data of PCNs were recorded. The diagnostic accuracy of CE-EUS in classifying PCNs was compared with that of CT, MRI and FB-EUS. The ability of CE-EUS to identify PCNs was evaluated by comparing the enhanced mode of PCNs.


There was a significant difference between benign and malignant lesions in enhanced mode (P = 0.017). The enhanced modes of benign lesions were mostly type II and type III, while those of malignant lesions were type 0, type I, and type IV. The sensitivity, specificity, and accuracy of type 0, type I, and type IV enhanced mode as the diagnostic criterion for malignant lesions were 80%, 65.3%, and 67.1%, respectively. CE-EUS demonstrated greater accuracy in identifying PCNs than did CT, MRI, and FB-EUS (CE-EUS vs. CT: 92.3% vs. 76.9%; CE-EUS vs. MRI: 93.0% vs. 78.9%; CE-EUS vs. FB-EUS: 92.7% vs. 84.2%).


Compared with CT, MRI, and FB-EUS, CE-EUS is better at differentiating PCNs. CE-EUS is expected to be another important imaging technique for the diagnosis of PCNs.


Contrast-enhanced endoscopic ultrasonography Endoscopic ultrasonography Pancreatic neoplasms/diagnostic imaging Computed tomography Magnetic resonance imaging 



This study was supported by the Scientific Research Fund of Army of China (No. 14BJZ01).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Lisen Zhong
    • 1
  • Ningli Chai
    • 1
  • Enqiang Linghu
    • 1
    Email author
  • Huikai Li
    • 1
  • Jing Yang
    • 1
  • Ping Tang
    • 1
  1. 1.Department of Gastroenterology and HepatologyChinese PLA General HospitalBeijingChina

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