Association Between Cannabis Use and Complications Related to Crohn’s Disease: A Retrospective Cohort Study

  • Chimezie MbachiEmail author
  • Bashar Attar
  • Yuchen Wang
  • Isaac Paintsil
  • Benjamin Mba
  • Setri Fugar
  • Rohit Agrawal
  • Roberto Carlos Simons-Linares
  • Palash Jaiswal
  • William Trick
  • Vikram Kotwal
Original Article



Crohn’s disease is an idiopathic inflammatory process that is occasionally associated with complications, which cause significant morbidity and mortality. The anti-inflammatory effect of cannabis in intestinal inflammation has been shown in several experimental models; it is unknown whether this correlates with fewer complications in Crohn’s disease patients.


To compare the prevalence of Crohn’s disease-related complications among cannabis users and non-users in patients admitted with a primary diagnosis of Crohn’s disease or a primary diagnosis of Crohn’s related complication and a secondary diagnosis of Crohn’s disease between 2012 and 2014.


We used data from the Healthcare Cost and Utilization Project–National Inpatient Sample. Cannabis users (615) were compared directly after propensity score match to non-users, in aspects of various complications and clinical end-points.


Among matched cohorts, Cannabis users were less likely to have the following: active fistulizing disease and intra-abdominal abscess (11.5% vs. 15.9%; aOR 0.68 [0.49 to 0.94], p = 0.025), blood product transfusion (5.0% vs. 8.0%; aOR 0.48 [0.30 to 0.79], p = 0.037), colectomy (3.7% vs. 7.5%; aOR 0.48 [0.29–0.80], p = 0.004), and parenteral nutrition requirement (3.4% vs. 6.7%, aOR 0.39 [0.23 to 0.68], p = 0.009).


Cannabis use may mitigate several of the well-described complications of Crohn’s disease among hospital inpatients. These effects could possibly be through the effect of cannabis in the endocannabinoid system.


Cannabis Crohn’s Complications Parenteral nutrition 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10620_2019_5556_MOESM1_ESM.docx (15 kb)
Supplementary material 1 (DOCX 15 kb)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Chimezie Mbachi
    • 1
    • 5
    Email author
  • Bashar Attar
    • 1
  • Yuchen Wang
    • 1
  • Isaac Paintsil
    • 1
  • Benjamin Mba
    • 1
  • Setri Fugar
    • 2
  • Rohit Agrawal
    • 1
  • Roberto Carlos Simons-Linares
    • 3
  • Palash Jaiswal
    • 4
  • William Trick
    • 1
  • Vikram Kotwal
    • 1
  1. 1.John H Stroger Hospital of Cook CountyChicagoUSA
  2. 2.Rush University Medical CentreChicagoUSA
  3. 3.Gastroenterology and Hepatology Department, Digestive Disease InstituteCleveland ClinicClevelandUSA
  4. 4.SUNY Downstate Medical CentreNew YorkUSA
  5. 5.ChicagoUSA

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