Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study
Background and Aim
Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population.
Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria.
After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old.
H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
KeywordsHelicobacter pylori Metabolic syndrome Cholesterol Lipid profile
- H. pylori
World Health Organization
Body mass index
Low-density lipoprotein cholesterol
High-density lipoprotein cholesterol
- Anti-HP IgG
Helicobacter pylori immunoglobulin G antibody
National Cholesterol Education Program
This work was supported by a Grant (No. 2011-0030001) of the National Research Foundation (NRF) for the Global Core Research Center (GCRC) funded by the Ministry of Science, ICT and Future Planning (MSIP), Republic of Korea.
SHL collected and analyzed the data and drafted the article. NK designed and supervised this study and edited this manuscript. JWK provided statistical support and helped to provide the table and figures. NK, SHL, SEK, GHP, JYL, KSP, JES, HJS, DSM, SCC, HJK and JHL helped to collect the data and edited the manuscript. JYY and JSK reviewed the manuscript. All authors have read and approved the final draft of this manuscript.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee, the 1964 Declaration of Helsinki, and its later amendments or comparable ethical standards.
Informed consent was obtained from all participants in this study.
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